Mdm2 MGI Mouse Gene Detail - MGI:96952 - transformed mouse 3T3 cell double minute 2

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_96952	protein coding gene	Chr10:117524780-117546663 (-)
129S1/SvImJ	MGP_129S1SvImJ_G0017761	protein coding gene	Chr10:120636918-120662030 (-)
A/J	MGP_AJ_G0017737	protein coding gene	Chr10:115909004-115931632 (-)
AKR/J	MGP_AKRJ_G0017699	protein coding gene	Chr10:119314449-119337350 (-)
BALB/cJ	MGP_BALBcJ_G0017700	protein coding gene	Chr10:116306890-116332248 (-)
C3H/HeJ	MGP_C3HHeJ_G0017525	protein coding gene	Chr10:119535199-119557492 (-)
C57BL/6NJ	MGP_C57BL6NJ_G0018155	protein coding gene	Chr10:124786893-124808453 (-)
CAROLI/EiJ	MGP_CAROLIEiJ_G0015836	protein coding gene	Chr10:110481727-110503005 (-)
CAST/EiJ	MGP_CASTEiJ_G0017085	protein coding gene	Chr10:119841316-119865319 (-)
CBA/J	MGP_CBAJ_G0017494	protein coding gene	Chr10:129723249-129749292 (-)
DBA/2J	MGP_DBA2J_G0017599	protein coding gene	Chr10:115057637-115080692 (-)
FVB/NJ	MGP_FVBNJ_G0017594	protein coding gene	Chr10:114022510-114045586 (-)
LP/J	MGP_LPJ_G0017672	protein coding gene	Chr10:121181891-121207093 (-)
NOD/ShiLtJ	MGP_NODShiLtJ_G0017623	protein coding gene	Chr10:132534248-132560281 (-)
NZO/HlLtJ	MGP_NZOHlLtJ_G0018195	protein coding gene	Chr10:119382259-119403777 (-)
PWK/PhJ	MGP_PWKPhJ_G0016869	protein coding gene	Chr10:115154437-115178073 (-)
SPRET/EiJ	MGP_SPRETEiJ_G0016659	protein coding gene	Chr10:118160014-118186787 (-)
WSB/EiJ	MGP_WSBEiJ_G0017147	protein coding gene	Chr10:119569983-119591545 (-)

Length	Strain/Species	Flank
genomic	17246	NCBI Gene Model \| MGI Sequence Detail	21884	C57BL/6J	± kb
transcript	NM_001428611	RefSeq \| MGI Sequence Detail	3060	C57BL/6
polypeptide	P23804	UniProt \| EBI \| MGI Sequence Detail	489	Not Applicable

TSS for Mdm2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr99469	Chr10:117546650-117546678 (-)	-1 bp
Tssr99468	Chr10:117546579-117546641 (-)	53 bp
Tssr99467	Chr10:117546549-117546566 (-)	105 bp
Tssr99466	Chr10:117546133-117546208 (-)	492 bp
Tssr99465	Chr10:117546098-117546110 (-)	559 bp
Tssr99464	Chr10:117546008-117546033 (-)	642 bp
Tssr99463	Chr10:117545993-117546004 (-)	664 bp
Tssr99462	Chr10:117545978-117545992 (-)	678 bp
Tssr99461	Chr10:117545920-117545937 (-)	734 bp
Tssr99460	Chr10:117537521-117537530 (-)	9,137 bp
Tssr99459	Chr10:117534940-117534946 (-)	11,720 bp
Tssr99458	Chr10:117531322-117531350 (-)	15,327 bp
Tssr99457	Chr10:117529179-117529186 (-)	17,480 bp
Tssr99456	Chr10:117529063-117529082 (-)	17,590 bp
Tssr99455	Chr10:117529040-117529049 (-)	17,618 bp
Tssr99454	Chr10:117526440-117526460 (-)	20,213 bp
Tssr99453	Chr10:117526404-117526422 (-)	20,250 bp
Tssr99452	Chr10:117526332-117526344 (-)	20,325 bp
Tssr99451	Chr10:117526126-117526137 (-)	20,531 bp
Tssr99450	Chr10:117525786-117525806 (-)	20,867 bp
Tssr99449	Chr10:117525770-117525785 (-)	20,885 bp

Mdm2 is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Igfbp3q2	Chr10, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 10, candidate genes for diabesity QTL Igfp3q2 (46 cM) are Aes (43 cM) and Hsp90b1 (49 cM). Aes shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets while Hsp90b1 shows differential expression between the restricted and unrestricted diets on the A/A background. At another locus, Mdm2 (66 cM) is a candidate gene for diabesity QTL Insq4 (59 cM). Mdm2 shows differential expression between the restricted and unrestricted diets on the A/a background.
Insq4	Chr10, 54.72 cM	Chr10:103909085-103909229	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 10, candidate genes for diabesity QTL Igfp3q2 (46 cM) are Aes (43 cM) and Hsp90b1 (49 cM). Aes shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets while Hsp90b1 shows differential expression between the restricted and unrestricted diets on the A/A background. At another locus, Mdm2 (66 cM) is a candidate gene for diabesity QTL Insq4 (59 cM). Mdm2 shows differential expression between the restricted and unrestricted diets on the A/a background.

*cM position of peak correlated region/marker

				Human Disease	Mouse Models
				chronic myeloid leukemia IDs chronic myeloid leukemia DOID:8552 DOID:8551 DOID:8606 EFO:0000339 ICD9CM:205.1 KEGG:05220 OMIM:608232 ORDO:521 UMLS_CUI:C0023473
				glioblastoma IDs glioblastoma DOID:3068 DOID:3075 DOID:3080 MESH:D005909 NCI:C129295 NCI:C39750 NCI:C9094 UMLS_CUI:C0017636 UMLS_CUI:C0278878 UMLS_CUI:C1514422
				hepatocellular carcinoma IDs hepatocellular carcinoma DOID:684 DOID:5005 EFO:0000182 ICD10CM:C22.0 MESH:D006528 NCI:C3099 OMIM:114550 ORDO:88673 UMLS_CUI:C2239176
				pancreatic ductal carcinoma IDs pancreatic ductal carcinoma DOID:3587 DOID:10023 ICD10CM:C25.3 ICD9CM:157.3 MESH:D021441 UMLS_CUI:C0153461 UMLS_CUI:C0887833
				sarcoma IDs sarcoma DOID:1115 DOID:3936 ICD10CM:C49 ICD9CM:171 ICD9CM:171.9 UMLS_CUI:C0153519

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early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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