Mmp10 MGI Mouse Gene Detail - MGI:97007 - matrix metallopeptidase 10

Symbol

Mmp10
Name

matrix metallopeptidase 10
Synonyms

stromelysin 2

Feature Type

protein coding gene
IDs

MGI:97007
NCBI Gene: 17384
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr9:7502353-7510241 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 9, 2.46 cM
Mapping Data

2 experiments

SNPs within 2kb

257 from dbSNP Build 142
Strain Annotations

18

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97007	protein coding gene	Chr9:7502343-7510243 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0034323	protein coding gene	Chr9:4364790-4374650 (+)
A/J	MGP_AJ_G0034301	protein coding gene	Chr9:4468314-4476562 (+)
AKR/J	MGP_AKRJ_G0034229	protein coding gene	Chr9:4327850-4340713 (+)
BALB/cJ	MGP_BALBcJ_G0034295	protein coding gene	Chr9:4202764-4211100 (+)
C3H/HeJ	MGP_C3HHeJ_G0034006	protein coding gene	Chr9:4538450-4546011 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0034817	protein coding gene	Chr9:4529821-4538932 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0031755	protein coding gene	Chr9:3745285-3752652 (+)
CAST/EiJ	MGP_CASTEiJ_G0033334	protein coding gene	Chr9:4533120-4544452 (+)
CBA/J	MGP_CBAJ_G0033979	protein coding gene	Chr9:4630332-4637909 (+)
DBA/2J	MGP_DBA2J_G0034136	protein coding gene	Chr9:4350102-4357703 (+)
FVB/NJ	MGP_FVBNJ_G0034081	protein coding gene	Chr9:4122596-4136315 (+)
LP/J	MGP_LPJ_G0034222	protein coding gene	Chr9:4416441-4426275 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0034125	protein coding gene	Chr9:5371790-5379499 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0034836	protein coding gene	Chr9:4330399-4339160 (+)
PWK/PhJ	MGP_PWKPhJ_G0033037	protein coding gene	Chr9:4470086-4478495 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0032875	protein coding gene	Chr9:4571470-4580539 (+)
WSB/EiJ	MGP_WSBEiJ_G0033449	protein coding gene	Chr9:4347777-4360286 (+)

Human Ortholog

MMP10, matrix metallopeptidase 10

Vertebrate Orthologs

2

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MMP10, matrix metallopeptidase 10
Synonyms

SL-2, STMY2
Links

HGNC:7156

NCBI Gene ID: 4319

neXtProt AC: NX_P09238

UniProt: P09238
Chr Location

11q22.2; chr11:102770502-102780628 (-) GRCh38

MGI Vertebrate Homology

Mmp10 stringent orthology
1 human;1 mouse;1 rat
HCOP

vertebrate homology predictions: MMP10
Protein SuperFamily

Peptidase_M10A_matrix
Gene Tree

Mmp10

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Phenotype Summary

4 phenotypes from 2 alleles in 2 genetic backgrounds
21 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

5
Endonuclease-mediated

1
Targeted

4
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

37 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mice homozygous for a knock-out allele exhibit increased susceptibility to bacterial infection.

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All GO Annotations

10
GO References

5

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

737
Tissues

17
cDNA Data

5
Literature Summary

9

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GEO

Expression Atlas

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All Sequences

33
RefSeq

2
UniProt

3
CCDS

CCDS22807.1

Ensembl

ENSMUSG00000047562 (Evidence)
NCBI Gene

17384

			Length	Strain/Species	Flank
genomic	ENSMUSG00000047562	Ensembl Gene Model \| MGI Sequence Detail	7889	C57BL/6J	± kb
transcript	ENSMUST00000034488	Ensembl \| MGI Sequence Detail	1722	Not Applicable
polypeptide	ENSMUSP00000034488	Ensembl \| MGI Sequence Detail	476	Not Applicable

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UniProt

3 Sequences
Protein Ontology

PR:000010470 stromelysin-2

(term hierarchy)
EC

3.4.24.22
InterPro Domains

IPR018486 Hemopexin, conserved site

IPR000585 Hemopexin-like domain

IPR036375 Hemopexin-like domain superfamily

IPR018487 Hemopexin-like repeats

IPR024079 Metallopeptidase, catalytic domain superfamily

IPR021190 Peptidase M10A

IPR033739 Peptidase M10A, catalytic domain

IPR021158 Peptidase M10A, cysteine switch, zinc binding site

IPR001818 Peptidase M10, metallopeptidase

IPR006026 Peptidase, metallopeptidase

IPR002477 Peptidoglycan binding-like

IPR036365 PGBD-like superfamily

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All nucleic 11

Genomic 3

cDNA 5

Primer pair 2

Other 1

Microarray probesets 3

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MGD-MRK-12277, MGI:2143274

Summaries

All 67

Developmental Gene Expression 9

Gene Ontology 5

Phenotypes 21
Earliest

J:17538 Gack S, et al., Phenotypic alterations in fos-transgenic mice correlate with changes in Fos/Jun-dependent collagenase type I expression. Regulation of mouse metalloproteinases by carcinogens, tumor promoters, cAMP, and Fos oncoprotein. J Biol Chem. 1994 Apr 8;269(14):10363-9
Latest

J:346183 Bobadilla Munoz M, et al., Loss of the matrix metalloproteinase-10 causes premature features of aging in satellite cells. Front Cell Dev Biol. 2023;11:1128534

TSS for Mmp10:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr83744	Chr9:7502341-7502346 (+)	-9 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/05/2024 MGI 6.24