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Map2 Gene Detail
Summary
  • Symbol
    Map2
  • Name
    microtubule-associated protein 2
  • Synonyms
    G1-397-34, MAP-2, Mtap2, repro4
  • Feature Type
    protein coding gene
  • IDs
    MGI:97175
    NCBI Gene: 17756
  • Alliance
    gene page
  • Transcription Start Sites
    32 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:66214432-66481742 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 33.49 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3314 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97175
 protein coding gene Chr1:66214337-66481742 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016112
 protein coding gene Chr1:66425946-66705450 (+)
A/J MGP_AJ_G0016095
 protein coding gene Chr1:64086030-64350654 (+)
AKR/J MGP_AKRJ_G0016052
 protein coding gene Chr1:65897571-66172682 (+)
BALB/cJ MGP_BALBcJ_G0016050
 protein coding gene Chr1:64144367-64411595 (+)
C3H/HeJ MGP_C3HHeJ_G0015881
 protein coding gene Chr1:66150240-66422853 (+)
C57BL/6NJ MGP_C57BL6NJ_G0016503
 protein coding gene Chr1:68984271-69265793 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014224
 protein coding gene Chr1:60042548-60301352 (+)
CAST/EiJ MGP_CASTEiJ_G0015465
 protein coding gene Chr1:65395417-65668484 (+)
CBA/J MGP_CBAJ_G0015854
 protein coding gene Chr1:71198334-71506430 (+)
DBA/2J MGP_DBA2J_G0015955
 protein coding gene Chr1:63468303-63735085 (+)
FVB/NJ MGP_FVBNJ_G0015958
 protein coding gene Chr1:62724873-62990569 (+)
LP/J MGP_LPJ_G0016027
 protein coding gene Chr1:67351886-67644171 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0015978
 protein coding gene Chr1:74176805-74481148 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016550
 protein coding gene Chr1:65845321-66123294 (+)
PWK/PhJ MGP_PWKPhJ_G0015252
 protein coding gene Chr1:62858015-63124683 (+)
SPRET/EiJ MGP_SPRETEiJ_G0015031
 protein coding gene Chr1:65316655-65595046 (+)
WSB/EiJ MGP_WSBEiJ_G0015527
 protein coding gene Chr1:65590442-65861339 (+)



Homology
more
  • Human Ortholog
    MAP2, microtubule associated protein 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAP2, microtubule associated protein 2
  • Synonyms
    MAP-2, MAP2A, MAP2B, MAP2C
  • Links
    NCBI Gene ID: 4133
    neXtProt AC: NX_P11137
    UniProt: P11137

  • Chr Location
    2q34; chr2:209424047-209734147 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    15 phenotypes from 3 alleles in 4 genetic backgrounds
    10 phenotypes from multigenic genotypes
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit altered contextual memory. Mice homozygous for another knock-out allele display decreased body weight, altered microtubule density and organization in Purkinje cell dendrites, and reduced dendritic length inhippocampal neurons.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    68
  • GO References
    42
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1333
  • Tissues
    217
  • cDNA Data
    287
  • Literature Summary
    428
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000015222 Ensembl Gene Model | MGI Sequence Detail 267311 C57BL/6J ±  kb
    transcript ENSMUST00000239213 Ensembl | MGI Sequence Detail 6259 Not Applicable  
    polypeptide ENSMUSP00000159224 Ensembl | MGI Sequence Detail 1989 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      17 Sequences
    • Protein Ontology
      PR:000010124 microtubule-associated protein 2
      (term hierarchy)
    • InterPro Domains
      IPR013588 MAP2/Tau projection
      IPR027324 Microtubule associated protein MAP2/MAP4/Tau
      IPR001084 Microtubule associated protein, tubulin-binding repeat
      IPR018459 RII binding domain
    • GlyGen
      P20357 8 sites, 3 N-linked glycans (3 sites), 1 O-linked glycan (5 sites)
    Molecular
    Reagents
    less
    • All nucleic 303
      cDNA 294
      Primer pair 8
      Other 1

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-12580, MGD-MRK-12585, MGI:3512774
    References
    more
    • Summaries
      All 540
      Developmental Gene Expression 428
      Gene Ontology 42
      Phenotypes 22
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:350103 Kantaputra P, et al., Homozygosity for a Rare Plec Variant Suggests a Contributory Role in Congenital Insensitivity to Pain. Int J Mol Sci. 2024 Jun 8;25(12)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory