Myc MGI Mouse Gene Detail - MGI:97250 - myelocytomatosis oncogene

Symbol

Myc
Name

myelocytomatosis oncogene
Synonyms

bHLHe39, c-myc, Myc2, Niard, Nird

Feature Type

protein coding gene
IDs

MGI:97250
NCBI Gene: 17869
Alliance

gene page
Transcription Start Sites

22 TSS

Sequence Map

Chr15:61857240-61862223 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 26.19 cM, cytoband D2-D3
Mapping Data

62 experiments

SNPs within 2kb

146 from dbSNP Build 142
Strain Annotations

18
PCR

5
RFLP

14

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_97250	protein coding gene	Chr15:61857190-61862223 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0021890	protein coding gene	Chr15:61322402-61329671 (+)
A/J	MGP_AJ_G0021849	protein coding gene	Chr15:58924253-58929729 (+)
AKR/J	MGP_AKRJ_G0021831	protein coding gene	Chr15:60570722-60576766 (+)
BALB/cJ	MGP_BALBcJ_G0021856	protein coding gene	Chr15:59115176-59121561 (+)
C3H/HeJ	MGP_C3HHeJ_G0021630	protein coding gene	Chr15:60690555-60696279 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022295	protein coding gene	Chr15:63628035-63634726 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0019833	protein coding gene	Chr15:56006532-56011549 (+)
CAST/EiJ	MGP_CASTEiJ_G0021148	protein coding gene	Chr15:61348962-61353977 (+)
CBA/J	MGP_CBAJ_G0021599	protein coding gene	Chr15:65902634-65910822 (+)
DBA/2J	MGP_DBA2J_G0021723	protein coding gene	Chr15:58789607-58794889 (+)
FVB/NJ	MGP_FVBNJ_G0021702	protein coding gene	Chr15:57840594-57845579 (+)
LP/J	MGP_LPJ_G0021794	protein coding gene	Chr15:61217450-61222509 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021725	protein coding gene	Chr15:70853292-70858309 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022318	protein coding gene	Chr15:60946801-60952650 (+)
PWK/PhJ	MGP_PWKPhJ_G0020893	protein coding gene	Chr15:58861598-58866677 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020731	protein coding gene	Chr15:60740324-60745309 (+)
WSB/EiJ	MGP_WSBEiJ_G0021204	protein coding gene	Chr15:60981351-60986384 (+)

Human Ortholog

MYC, MYC proto-oncogene, bHLH transcription factor

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

MYC, MYC proto-oncogene, bHLH transcription factor
Synonyms

bHLHe39, c-Myc, MRTL, MYCC
Links

HGNC:7553

NCBI Gene ID: 4609

neXtProt AC: NX_P01106

UniProt: P01106
Chr Location

8q24.21; chr8:127735434-127742951 (+) GRCh38

MGI Vertebrate Homology

Myc stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: MYC
Protein SuperFamily

Myc_protein
Gene Tree

Myc

Diseases

5 with Myc mouse models; 9 with human MYC associations

Human Disease

Mouse Models

breast cancer

IDs

View 7 models

Burkitt lymphoma

IDs

View 4 models

autosomal dominant polycystic kidney disease

IDs

View 1 model

hepatocellular carcinoma

IDs

View 8 models

pancreatic carcinoma

IDs

View 3 models

acute promyelocytic leukemia

IDs

angiosarcoma

IDs

demyelinating disease

IDs

lung adenocarcinoma

IDs

prostate adenocarcinoma

IDs

prostate cancer

IDs

urinary bladder cancer

IDs

Click on a disease name to see all genes associated with that disease.

Mutations/Alleles

18 with disease annotations

References

22 with disease annotations

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Phenotype Summary

199 phenotypes from 42 alleles in 39 genetic backgrounds
140 phenotypes from multigenic genotypes
2 images
776 phenotype references

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

90
Chemically induced (other)

3
Endonuclease-mediated

8
Gene trapped

4
Radiation induced

2
Targeted

40
Transgenic

32
Transposon induced

1
Genomic Mutations

6 involving Myc
Incidental Mutations

APF , CvDC
Find Mice (IMSR)

43 strains or lines available
Comparison Matrix

Gene Expression + Phenotype

Mutations affect growth and development of heart, pericardium, neural tube, vasculogenesis and erythropoeisis. Homozygous null mutants die by embryonic day 10.5. Heterozygotes have reduced body size and multiorgan hypoplasia; females have small litters.

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All GO Annotations

176
GO References

50

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

1549
Tissues

387
cDNA Data

88
Literature Summary

272

Images

Tissue x Stage Matrix

Comparison Matrix

Gene Expression + Phenotype

Other Mouse Links

Allen Institute

GENSAT

GEO

Expression Atlas
Other Vertebrate Links

GEISHA MYC

Xenbase myc

ZFIN myca, mycb

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All Sequences

68
RefSeq

8
UniProt

5
CCDS

CCDS27504.1, CCDS49614.1, CCDS49615.1

Ensembl

ENSMUSG00000022346 (Evidence)
NCBI Gene

17869

			Length	Strain/Species	Flank
genomic	ENSMUSG00000022346	Ensembl Gene Model \| MGI Sequence Detail	4984	C57BL/6J	± kb
transcript	ENSMUST00000022971	Ensembl \| MGI Sequence Detail	2338	Not Applicable
polypeptide	ENSMUSP00000022971	Ensembl \| MGI Sequence Detail	454	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000000084 c-myc protein

(term hierarchy)
InterPro Domains

IPR036638 Helix-loop-helix DNA-binding domain superfamily

IPR003327 Leucine zipper, Myc

IPR050433 Myc family transcription factors

IPR011598 Myc-type, basic helix-loop-helix (bHLH) domain

IPR002418 Transcription regulator Myc

IPR012682 Transcription regulator Myc, N-terminal
GlyGen

P01108 2 sites, 1 O-linked glycan (1 site)

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All nucleic 187

Genomic 46

cDNA 89

Primer pair 28

Other 24

Microarray probesets 3

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MGD-MRK-12736, MGI:2146128

Summaries

All 1560

Developmental Gene Expression 272

Diseases 22

Gene Ontology 50

Phenotypes 776
Earliest

J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
Latest

J:353458 Mule P, et al., WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors. Gastroenterology. 2024 Jul 5;

TSS for Myc:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr131405	Chr15:61857226-61857246 (+)	-4 bp
Tssr131406	Chr15:61857389-61857405 (+)	157 bp
Tssr131407	Chr15:61858887-61858908 (+)	1,658 bp
Tssr131408	Chr15:61859153-61859167 (+)	1,920 bp
Tssr131409	Chr15:61859208-61859237 (+)	1,983 bp
Tssr131410	Chr15:61859259-61859340 (+)	2,060 bp
Tssr131411	Chr15:61859341-61859370 (+)	2,116 bp
Tssr131412	Chr15:61859457-61859472 (+)	2,225 bp
Tssr131413	Chr15:61859528-61859602 (+)	2,325 bp
Tssr131414	Chr15:61859640-61859649 (+)	2,405 bp
Tssr131415	Chr15:61859867-61859965 (+)	2,676 bp
Tssr131416	Chr15:61860013-61860022 (+)	2,778 bp
Tssr131417	Chr15:61860075-61860086 (+)	2,841 bp
Tssr131418	Chr15:61860093-61860100 (+)	2,857 bp
Tssr131419	Chr15:61860806-61860810 (+)	3,568 bp
Tssr131420	Chr15:61861241-61861254 (+)	4,008 bp
Tssr131421	Chr15:61861266-61861284 (+)	4,035 bp
Tssr131422	Chr15:61861290-61861303 (+)	4,057 bp
Tssr131423	Chr15:61861331-61861343 (+)	4,097 bp
Tssr131424	Chr15:61861405-61861416 (+)	4,171 bp
Tssr131425	Chr15:61861883-61861907 (+)	4,655 bp
Tssr131426	Chr15:61861953-61861958 (+)	4,716 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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