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Ncam1 Gene Detail
Summary
  • Symbol
    Ncam1
  • Name
    neural cell adhesion molecule 1
  • Synonyms
    CD56, E-NCAM, NCAM, NCAM-1, NCAM-120, NCAM-140, NCAM-180
  • Feature Type
    protein coding gene
  • IDs
    MGI:97281
    NCBI Gene: 17967
  • Alliance
    gene page
  • Transcription Start Sites
    37 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:49413436-49710225 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 26.83 cM
  • Mapping Data
    31 experiments
Strain
Comparison
more
  • SNPs within 2kb
    6967 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    5
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97281
 protein coding gene Chr9:49413434-49710909 (-)
129S1/SvImJ MGP_129S1SvImJ_G0034774
 protein coding gene Chr9:48332765-48640683 (-)
A/J MGP_AJ_G0034755
 protein coding gene Chr9:46892805-47190150 (-)
AKR/J MGP_AKRJ_G0034683
 protein coding gene Chr9:47866918-48177817 (-)
BALB/cJ MGP_BALBcJ_G0034747
 protein coding gene Chr9:46613196-46914125 (-)
C3H/HeJ MGP_C3HHeJ_G0034457
 protein coding gene Chr9:48341111-48643190 (-)
C57BL/6NJ MGP_C57BL6NJ_G0035267
 protein coding gene Chr9:49700289-50012557 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0032180
 protein coding gene Chr9:46373963-46670491 (-)
CAST/EiJ MGP_CASTEiJ_G0033779
 protein coding gene Chr9:48277813-48593666 (-)
CBA/J MGP_CBAJ_G0034429
 protein coding gene Chr9:51485411-51814242 (-)
DBA/2J MGP_DBA2J_G0034588
 protein coding gene Chr9:46747873-47049739 (-)
FVB/NJ MGP_FVBNJ_G0034529
 protein coding gene Chr9:45989051-46287542 (-)
LP/J MGP_LPJ_G0034669
 protein coding gene Chr9:48713805-49015501 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0034573
 protein coding gene Chr9:53136176-53449444 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0035288
 protein coding gene Chr9:47820172-48122844 (-)
PWK/PhJ MGP_PWKPhJ_G0033484
 protein coding gene Chr9:46717055-47020194 (-)
SPRET/EiJ MGP_SPRETEiJ_G0033319
 protein coding gene Chr9:48153754-48460185 (-)
WSB/EiJ MGP_WSBEiJ_G0033892
 protein coding gene Chr9:47850406-48157403 (-)



Homology
more
  • Human Ortholog
    NCAM1, neural cell adhesion molecule 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NCAM1, neural cell adhesion molecule 1
  • Synonyms
    CD56, MSK39, NCAM
  • Links
    NCBI Gene ID: 4684
    neXtProt AC: NX_P13591
    UniProt: P13591

  • Chr Location
    11q23.2; chr11:112961275-113278436 (+)  GRCh38
Human Diseases
more
  • Diseases
    6 with human NCAM1 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    29 phenotypes from 6 alleles in 9 genetic backgrounds
    4 phenotypes from multigenic genotypes
    114 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants show impairment in Morris water maze test, reduced brain and olfactory bulb size, hypoplasic corticospinal tract, abnormally distributed anterior pituitary cell types, and neuromuscular junctions defects. Homozygotes for a null allele exhibit age-dependent retinal abnormalities.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    48
  • GO References
    19
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    2071
  • Tissues
    455
  • cDNA Data
    52
  • Literature Summary
    354
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039542 Ensembl Gene Model | MGI Sequence Detail 296790 C57BL/6J ±  kb
    transcript ENSMUST00000194252 Ensembl | MGI Sequence Detail 6564 Not Applicable  
    polypeptide ENSMUSP00000142331 Ensembl | MGI Sequence Detail 1089 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 105
      Genomic 28
      cDNA 59
      Primer pair 10
      Other 8

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-12786
    References
    more
    • Summaries
      All 591
      Developmental Gene Expression 354
      Gene Ontology 19
      Phenotypes 114
    • Earliest
      J:37744 Rougon G, et al., Tissue- and developmental stage-specific forms of a neural cell surface antigen linked to differences in glycosylation of a common polypeptide. EMBO J. 1982;1(10):1239-44
    • Latest
      J:350469 Alderman PJ, et al., Delayed maturation and migration of excitatory neurons in the juvenile mouse paralaminar amygdala. Neuron. 2024 Feb 21;112(4):574-592.e10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory