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Nkx2-3 Gene Detail
Summary
  • Symbol
    Nkx2-3
  • Name
    NK2 homeobox 3
  • Synonyms
    Nkx-2.3, Nkx2.3, tinman
  • Feature Type
    protein coding gene
  • IDs
    MGI:97348
    NCBI Gene: 18089
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:43600764-43604331 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 36.67 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    139 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97348
 protein coding gene Chr19:43600764-43604331 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025153
 protein coding gene Chr19:43020088-43023657 (+)
A/J MGP_AJ_G0025130
 protein coding gene Chr19:40969544-40973117 (+)
AKR/J MGP_AKRJ_G0025098
 protein coding gene Chr19:42263030-42266599 (+)
BALB/cJ MGP_BALBcJ_G0025124
 protein coding gene Chr19:41015547-41019120 (+)
C3H/HeJ MGP_C3HHeJ_G0024884
 protein coding gene Chr19:42442315-42445883 (+)
C57BL/6NJ MGP_C57BL6NJ_G0025567
 protein coding gene Chr19:44085902-44089469 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0022981
 protein coding gene Chr19:40270257-40273806 (+)
CAST/EiJ MGP_CASTEiJ_G0024349
 protein coding gene Chr19:42137265-42140830 (+)
CBA/J MGP_CBAJ_G0024864
 protein coding gene Chr19:46269018-46272586 (+)
DBA/2J MGP_DBA2J_G0024996
 protein coding gene Chr19:40801069-40804642 (+)
FVB/NJ MGP_FVBNJ_G0024957
 protein coding gene Chr19:40554081-40558311 (+)
LP/J MGP_LPJ_G0025082
 protein coding gene Chr19:42989543-42993112 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0024988
 protein coding gene Chr19:45819486-45823059 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0025625
 protein coding gene Chr19:42357508-42361076 (+)
PWK/PhJ MGP_PWKPhJ_G0024098
 protein coding gene Chr19:40697360-40700929 (+)
SPRET/EiJ MGP_SPRETEiJ_G0023902
 protein coding gene Chr19:41061944-41065507 (+)
WSB/EiJ MGP_WSBEiJ_G0024419
 protein coding gene Chr19:42494283-42497848 (+)



Homology
more
  • Human Ortholog
    NKX2-3, NK2 homeobox 3
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NKX2-3, NK2 homeobox 3
  • Synonyms
    CSX3, NK2.3, NKX2.3, NKX2C, NKX4-3
  • Links
    NCBI Gene ID: 159296
    neXtProt AC: NX_Q8TAU0
    UniProt: Q8TAU0

  • Chr Location
    10q24.2; chr10:99532942-99536524 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    58 phenotypes from 2 alleles in 3 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes exhibit postnatal lethality due to acute intestinal malabsorption. Survivors recover well but exhibit splenic and Peyer's patch hypoplasia, intestinal villus malformation, gut truncation and distension, abnormal molar and sublingual gland development, and deranged lymphocyte homing.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    955
  • Tissues
    133
  • cDNA Data
    12
  • Literature Summary
    17
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18089 NCBI Gene Model | MGI Sequence Detail 3568 C57BL/6J ±  kb
    transcript NM_008699 RefSeq | MGI Sequence Detail 2145 ZRU/MplStud  
    polypeptide P97334 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 25
      Genomic 6
      cDNA 12
      Primer pair 4
      Other 3

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-12890
    References
    more
    • Summaries
      All 61
      Developmental Gene Expression 17
      Gene Ontology 11
      Phenotypes 19
    • Earliest
      J:2959 Price M, et al., Regional expression of the homeobox gene Nkx-2.2 in the developing mammalian forebrain. Neuron. 1992 Feb;8(2):241-55
    • Latest
      J:346457 Gao X, et al., Nkx2.3 transcription factor is a key regulator of mucous cell identity in salivary glands. Dev Biol. 2024 May;509:1-10
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/05/2024
    MGI 6.24     		The Jackson Laboratory