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Slc10a1 Gene Detail
Summary
  • Symbol
    Slc10a1
  • Name
    solute carrier family 10 (sodium/bile acid cotransporter family), member 1
  • Synonyms
    Ntcp, sodium bile acid cotransporting polypeptide
  • Feature Type
    protein coding gene
  • IDs
    MGI:97379
    NCBI Gene: 20493
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:80999959-81015479 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 37.21 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    444 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97379
 protein coding gene Chr12:80999957-81015479 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019896
 protein coding gene Chr12:81377154-81397071 (-)
A/J MGP_AJ_G0019854
 protein coding gene Chr12:78398738-78413793 (-)
AKR/J MGP_AKRJ_G0019829
 protein coding gene Chr12:80542556-80557288 (-)
BALB/cJ MGP_BALBcJ_G0019833
 protein coding gene Chr12:78648086-78663387 (-)
C3H/HeJ MGP_C3HHeJ_G0019639
 protein coding gene Chr12:81010425-81025223 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020285
 protein coding gene Chr12:83753246-83767933 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017904
 protein coding gene Chr12:75389342-75404744 (-)
CAST/EiJ MGP_CASTEiJ_G0019189
 protein coding gene Chr12:75882304-75899044 (-)
CBA/J MGP_CBAJ_G0019610
 protein coding gene Chr12:87013545-87028228 (-)
DBA/2J MGP_DBA2J_G0019725
 protein coding gene Chr12:78008904-78023836 (-)
FVB/NJ MGP_FVBNJ_G0019711
 protein coding gene Chr12:76832266-76849423 (-)
LP/J MGP_LPJ_G0019797
 protein coding gene Chr12:81283677-81299740 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019750
 protein coding gene Chr12:90005827-90023871 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020320
 protein coding gene Chr12:80077975-80095829 (-)
PWK/PhJ MGP_PWKPhJ_G0018955
 protein coding gene Chr12:72408995-72425521 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018749
 protein coding gene Chr12:74589916-74608647 (-)
WSB/EiJ MGP_WSBEiJ_G0019242
 protein coding gene Chr12:80714429-80729436 (-)



Homology
more
  • Human Ortholog
    SLC10A1, solute carrier family 10 member 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC10A1, solute carrier family 10 member 1
  • Synonyms
    FHCA2, NTCP
  • Links
    NCBI Gene ID: 6554
    neXtProt AC: NX_Q14973
    UniProt: Q14973

  • Chr Location
    14q24.1; chr14:69775416-69797241 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 2 alleles in 2 genetic backgrounds
    10 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele show impaired hepatic uptake of conjugated bile acids (BAs) and Myrcludex B binding. A subset of adult homozygotes exhibit hypercholanemia, reduced body weight, increased serum alkaline phosphatase and bilirubin levels but no overt liver damage.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    724
  • Tissues
    7
  • cDNA Data
    20
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20493 NCBI Gene Model | MGI Sequence Detail 15521 C57BL/6J ±  kb
    transcript NM_001361972 RefSeq | MGI Sequence Detail 1747 ZRU/MplStud  
    polypeptide O08705 UniProt | EBI | MGI Sequence Detail 362 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      3 Sequences
    • Protein Ontology
      PR:000014917 hepatic sodium/bile acid cotransporter
      (term hierarchy)
    • InterPro Domains
      IPR004710 Bile acid:sodium symporter
      IPR002657 Bile acid:sodium symporter/arsenical resistance protein Acr3
      IPR038770 Sodium/solute symporter superfamily
    • GlyGen
      O08705 6 sites, 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 26
      Genomic 2
      cDNA 20
      Primer pair 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-12936
    References
    more
    • Summaries
      All 54
      Developmental Gene Expression 5
      Gene Ontology 7
      Phenotypes 10
    • Earliest
      J:692 Hagenbuch B, et al., Functional expression cloning and characterization of the hepatocyte Na+/bile acid cotransport system. Proc Natl Acad Sci U S A. 1991 Dec 1;88(23):10629-33
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    12/17/2024
    MGI 6.24     		The Jackson Laboratory