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Ntrk2 Gene Detail
Summary
  • Symbol
    Ntrk2
  • Name
    neurotrophic tyrosine kinase, receptor, type 2
  • Synonyms
    C030027L06Rik, Tkrb, trkB
  • Feature Type
    protein coding gene
  • IDs
    MGI:97384
    NCBI Gene: 18212
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:58954383-59281784 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 31.20 cM
  • Mapping Data
    10 experiments
Strain
Comparison
more
  • SNPs within 2kb
    9878 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97384
 protein coding gene Chr13:58954363-59281784 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020636
 protein coding gene Chr13:58473190-58811609 (+)
A/J MGP_AJ_G0020590
 protein coding gene Chr13:56295981-56615263 (+)
AKR/J MGP_AKRJ_G0020568
 protein coding gene Chr13:57976403-58309050 (+)
BALB/cJ MGP_BALBcJ_G0020586
 protein coding gene Chr13:56554304-56876124 (+)
C3H/HeJ MGP_C3HHeJ_G0020385
 protein coding gene Chr13:57771880-58105510 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021020
 protein coding gene Chr13:60250267-60599545 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018602
 protein coding gene Chr13:54188527-54508677 (+)
CAST/EiJ MGP_CASTEiJ_G0019899
 protein coding gene Chr13:57915862-58269614 (+)
CBA/J MGP_CBAJ_G0020345
 protein coding gene Chr13:62522904-62879363 (+)
DBA/2J MGP_DBA2J_G0020468
 protein coding gene Chr13:55841555-56168324 (+)
FVB/NJ MGP_FVBNJ_G0020447
 protein coding gene Chr13:55327212-55649690 (+)
LP/J MGP_LPJ_G0020544
 protein coding gene Chr13:58735278-59074297 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020476
 protein coding gene Chr13:61869137-62211224 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021063
 protein coding gene Chr13:57575323-57915824 (+)
PWK/PhJ MGP_PWKPhJ_G0019655
 protein coding gene Chr13:55857429-56191636 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019482
 protein coding gene Chr13:56477794-56800707 (+)
WSB/EiJ MGP_WSBEiJ_G0019961
 protein coding gene Chr13:58009870-58358273 (+)



Homology
more
  • Human Ortholog
    NTRK2, neurotrophic receptor tyrosine kinase 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    NTRK2, neurotrophic receptor tyrosine kinase 2
  • Synonyms
    DEE58, EIEE58, GP145-TrkB, OBHD, trk-B, TRKB
  • Links
    NCBI Gene ID: 4915
    neXtProt AC: NX_Q16620
    UniProt: Q16620

  • Chr Location
    9q21.33; chr9:84668375-85095751 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human NTRK2 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    143 phenotypes from 20 alleles in 27 genetic backgrounds
    14 phenotypes from multigenic genotypes
    275 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Different lines of homozygous mice show varied abnormalities including innervation and neural defects, rod defects, impaired ovarian folliculogenesis, and reduced postnatal survival. Homozygotes for a point mutation are normal, but are subject to pharmacological control of signalling.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    162
  • GO References
    47
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1165
  • Tissues
    249
  • cDNA Data
    28
  • Literature Summary
    199
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000055254 Ensembl Gene Model | MGI Sequence Detail 327402 C57BL/6J ±  kb
    transcript ENSMUST00000079828 Ensembl | MGI Sequence Detail 8744 Not Applicable  
    polypeptide ENSMUSP00000078757 Ensembl | MGI Sequence Detail 821 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      10 Sequences
    • Protein Ontology
      PR:000011470 BDNF/NT-3 growth factors receptor
      (term hierarchy)
    • EC
      2.7.10.1
    • InterPro Domains
      IPR020455 BDNF/NT-3 growth factors receptor NTRK2
      IPR050958 Cell Adhesion and Cytoskeletal Organization
      IPR000483 Cysteine-rich flanking region, C-terminal
      IPR020777 Growth factor receptor NTRK
      IPR031635 Growth factor receptor NTRK, leucine rich repeat C-terminal
      IPR013098 Immunoglobulin I-set
      IPR007110 Immunoglobulin-like domain
      IPR036179 Immunoglobulin-like domain superfamily
      IPR013783 Immunoglobulin-like fold
      IPR003599 Immunoglobulin subtype
      IPR003598 Immunoglobulin subtype 2
      IPR001611 Leucine-rich repeat
      IPR032675 Leucine-rich repeat domain superfamily
      IPR000372 Leucine-rich repeat N-terminal domain
      IPR051170 Neural and epithelial cell adhesion domain-containing protein
      IPR017441 Protein kinase, ATP binding site
      IPR000719 Protein kinase domain
      IPR011009 Protein kinase-like domain superfamily
      IPR050122 Receptor Tyrosine Kinase
      IPR001245 Serine-threonine/tyrosine-protein kinase, catalytic domain
      IPR008266 Tyrosine-protein kinase, active site
      IPR020635 Tyrosine-protein kinase, catalytic domain
      IPR002011 Tyrosine-protein kinase, receptor class II, conserved site
    • GlyGen
      P15209 14 sites, 33 N-linked glycans (10 sites), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 65
      cDNA 34
      Primer pair 21
      Other 10

      Microarray probesets 11
    Other
    Accession IDs
    less
    MGD-MRK-12943, MGD-MRK-15126, MGI:1924721, MGI:2145299
    References
    more
    • Summaries
      All 603
      Developmental Gene Expression 199
      Gene Ontology 47
      Phenotypes 275
    • Earliest
      J:182573 Roderick TH, Producing and detecting paracentric chromosomal inversions in mice. Mutat Res. 1971 Jan;11(1):59-69
    • Latest
      J:354315 Lowenstein ED, et al., Molecular Characterization of Nodose Ganglia Development Reveals a Novel Population of Phox2b+ Glial Progenitors in Mice. J Neurosci. 2024 Jul 10;44(28)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory