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Pax5 Gene Detail
Summary
  • Symbol
    Pax5
  • Name
    paired box 5
  • Synonyms
    EBB-1, Pax-5
  • Feature Type
    protein coding gene
  • IDs
    MGI:97489
    NCBI Gene: 18507
  • Alliance
    gene page
  • Transcription Start Sites
    14 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:44524757-44710487 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 23.55 cM
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5066 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97489
 protein coding gene Chr4:44524748-44710694 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028235
 protein coding gene Chr4:42708807-42896188 (-)
A/J MGP_AJ_G0028192
 protein coding gene Chr4:41185046-41370356 (-)
AKR/J MGP_AKRJ_G0028144
 protein coding gene Chr4:42145136-42339899 (-)
BALB/cJ MGP_BALBcJ_G0028212
 protein coding gene Chr4:41269401-41455289 (-)
C3H/HeJ MGP_C3HHeJ_G0027934
 protein coding gene Chr4:42761987-42954293 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028653
 protein coding gene Chr4:44326582-44525409 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025963
 protein coding gene Chr4:38597789-38772280 (-)
CAST/EiJ MGP_CASTEiJ_G0027373
 protein coding gene Chr4:42283975-42479081 (-)
CBA/J MGP_CBAJ_G0027900
 protein coding gene Chr4:45702105-45892694 (-)
DBA/2J MGP_DBA2J_G0028049
 protein coding gene Chr4:41082475-41268042 (-)
FVB/NJ MGP_FVBNJ_G0028016
 protein coding gene Chr4:40305602-40494716 (-)
LP/J MGP_LPJ_G0028148
 protein coding gene Chr4:42774874-42961928 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028040
 protein coding gene Chr4:48865355-49061336 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028689
 protein coding gene Chr4:42366717-42556981 (-)
PWK/PhJ MGP_PWKPhJ_G0027097
 protein coding gene Chr4:41127630-41319705 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026926
 protein coding gene Chr4:41888682-42082281 (-)
WSB/EiJ MGP_WSBEiJ_G0027451
 protein coding gene Chr4:42240013-42433438 (-)



Homology
more
  • Human Ortholog
    PAX5, paired box 5
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PAX5, paired box 5
  • Synonyms
    ALL3, BSAP, PAX-5
  • Links
    NCBI Gene ID: 5079
    neXtProt AC: NX_Q02548
    UniProt: Q02548

  • Chr Location
    9p13.2; chr9:36833269-37034268 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PAX5 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    69 phenotypes from 11 alleles in 15 genetic backgrounds
    24 phenotypes from multigenic genotypes
    82 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Null mutants exhibit impaired development of the midbrain resulting in a reduced inferior colliculus and an altered cerebellar folial pattern, failure of B cell differentiation, runting, and high postnatal mortality with few survivors.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    35
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1016
  • Tissues
    129
  • cDNA Data
    27
  • Literature Summary
    57
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000014030 Ensembl Gene Model | MGI Sequence Detail 185731 C57BL/6J ±  kb
    transcript ENSMUST00000014174 Ensembl | MGI Sequence Detail 8004 Not Applicable  
    polypeptide ENSMUSP00000014174 Ensembl | MGI Sequence Detail 391 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 3
      cDNA 27
      Primer pair 9
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13148, MGD-MRK-13157
    References
    more
    • Summaries
      All 218
      Developmental Gene Expression 57
      Gene Ontology 15
      Phenotypes 82
    • Earliest
      J:26648 Barberis A, et al., A novel B-cell lineage-specific transcription factor present at early but not late stages of differentiation. Genes Dev. 1990 May;4(5):849-59
    • Latest
      J:352993 Krishnamurthy A, et al., Engrailed transcription factors direct excitatory cerebellar neuron diversity and survival. Development. 2024 Jul 15;151(14):dev202502
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory