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Furin Gene Detail
Summary
  • Symbol
    Furin
  • Name
    furin, paired basic amino acid cleaving enzyme
  • Synonyms
    9130404I01Rik, Fur, PACE, Pcsk3, SPC1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97513
    NCBI Gene: 18550
  • Alliance
    gene page
  • Transcription Start Sites
    20 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:80038942-80055188 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.65 cM, cytoband D1-E2
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    391 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97513
 protein coding gene Chr7:80038333-80055188 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032415
 protein coding gene Chr7:82360191-82378087 (-)
A/J MGP_AJ_G0032394
 protein coding gene Chr7:80432182-80448817 (-)
AKR/J MGP_AKRJ_G0032330
 protein coding gene Chr7:82177031-82193666 (-)
BALB/cJ MGP_BALBcJ_G0032406
 protein coding gene Chr7:80106800-80124303 (-)
C3H/HeJ MGP_C3HHeJ_G0032119
 protein coding gene Chr7:82824963-82841830 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032898
 protein coding gene Chr7:85596525-85615100 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029906
 protein coding gene Chr7:82952599-82969373 (-)
CAST/EiJ MGP_CASTEiJ_G0031447
 protein coding gene Chr7:73713405-73730076 (-)
CBA/J MGP_CBAJ_G0032085
 protein coding gene Chr7:88435580-88455086 (-)
DBA/2J MGP_DBA2J_G0032240
 protein coding gene Chr7:78989968-79007048 (-)
FVB/NJ MGP_FVBNJ_G0032195
 protein coding gene Chr7:78904069-78921335 (-)
LP/J MGP_LPJ_G0032321
 protein coding gene Chr7:83599935-83617698 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032232
 protein coding gene Chr7:88589606-88608787 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032916
 protein coding gene Chr7:81607111-81627046 (-)
PWK/PhJ MGP_PWKPhJ_G0031167
 protein coding gene Chr7:72178349-72195664 (-)
SPRET/EiJ MGP_SPRETEiJ_G0031008
 protein coding gene Chr7:68617998-68635671 (-)
WSB/EiJ MGP_WSBEiJ_G0031565
 protein coding gene Chr7:81969903-81987772 (-)



Homology
more
  • Human Ortholog
    FURIN, furin, paired basic amino acid cleaving enzyme
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    FURIN, furin, paired basic amino acid cleaving enzyme
  • Synonyms
    FUR, PACE, PCSK3, SPC1
  • Links
    NCBI Gene ID: 5045
    neXtProt AC: NX_P09958
    UniProt: P09958

  • Chr Location
    15q26.1; chr15:90868588-90883564 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    47 phenotypes from 4 alleles in 7 genetic backgrounds
    12 phenotypes from multigenic genotypes
    51 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null embryos die at E10.5-E11.5. Embryos homozygous for one knock-out allele show multiple tissue abnormalities including abnormal yolk sac vasculature and chorioallantoic fusion, failure of axial rotation, a kinked neural tube, exencephaly and severe ventral closure and cardiac defects.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    81
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    843
  • Tissues
    72
  • cDNA Data
    98
  • Literature Summary
    22
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18550 NCBI Gene Model | MGI Sequence Detail 16247 C57BL/6J ±  kb
    transcript NM_011046 RefSeq | MGI Sequence Detail 4336 ZRU/MplStud  
    polypeptide P23188 UniProt | EBI | MGI Sequence Detail 793 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 106
      Genomic 1
      cDNA 99
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13193, MGD-MRK-9893, MGI:1925399
    References
    more
    • Summaries
      All 135
      Developmental Gene Expression 22
      Gene Ontology 20
      Phenotypes 51
    • Earliest
      J:23406 Hatsuzawa K, et al., Structure and expression of mouse furin, a yeast Kex2-related protease. Lack of processing of coexpressed prorenin in GH4C1 cells. J Biol Chem. 1990 Dec 25;265(36):22075-8
    • Latest
      J:355548 Xie S, et al., Cerebral furin deficiency causes hydrocephalus in mice. Genes Dis. 2024 May;11(3):101009
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory