About   Help   FAQ
Pdgfa Gene Detail
Summary
  • Symbol
    Pdgfa
  • Name
    platelet derived growth factor, alpha
  • Feature Type
    protein coding gene
  • IDs
    MGI:97527
    NCBI Gene: 18590
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:138961769-138983125 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 77.65 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    501 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97527
 protein coding gene Chr5:138961761-138986336 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030274
 protein coding gene Chr5:143910436-143934106 (-)
A/J MGP_AJ_G0030243
 protein coding gene Chr5:137821755-137843541 (-)
AKR/J MGP_AKRJ_G0030175
 protein coding gene Chr5:142117632-142140873 (-)
BALB/cJ MGP_BALBcJ_G0030260
 protein coding gene Chr5:139063191-139084719 (-)
C3H/HeJ MGP_C3HHeJ_G0029971
 protein coding gene Chr5:142892889-142916168 (-)
C57BL/6NJ MGP_C57BL6NJ_G0030705
 protein coding gene Chr5:149232517-149255478 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0027923
 protein coding gene Chr5:131686282-131707853 (-)
CAST/EiJ MGP_CASTEiJ_G0029376
 protein coding gene Chr5:142288812-142315485 (-)
CBA/J MGP_CBAJ_G0029941
 protein coding gene Chr5:155371112-155392244 (-)
DBA/2J MGP_DBA2J_G0030091
 protein coding gene Chr5:137644518-137665669 (-)
FVB/NJ MGP_FVBNJ_G0030046
 protein coding gene Chr5:136731830-136753526 (-)
LP/J MGP_LPJ_G0030177
 protein coding gene Chr5:144531704-144557610 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030077
 protein coding gene Chr5:158083632-158105855 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0030745
 protein coding gene Chr5:141915442-141940693 (-)
PWK/PhJ MGP_PWKPhJ_G0029091
 protein coding gene Chr5:136630103-136652290 (-)
SPRET/EiJ MGP_SPRETEiJ_G0028927
 protein coding gene Chr5:139604123-139625231 (-)
WSB/EiJ MGP_WSBEiJ_G0029450
 protein coding gene Chr5:142681166-142704526 (-)



Homology
more
  • Human Ortholog
    PDGFA, platelet derived growth factor subunit A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PDGFA, platelet derived growth factor subunit A
  • Synonyms
    PDGF1, PDGF-A
  • Links
    NCBI Gene ID: 5154
    neXtProt AC: NX_P04085
    UniProt: P04085

  • Chr Location
    7p22.3; chr7:497258-520700 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PDGFA associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    29 phenotypes from 2 alleles in 4 genetic backgrounds
    29 phenotypes from multigenic genotypes
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation die either before E10.0 or postnatally. The latter exhibit lung emphysema, reduced numbers of oligodendrocytes, tremors, and abnormalities of the skin, hair follicles, and gastrointestinal lining.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    84
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1775
  • Tissues
    460
  • cDNA Data
    14
  • Literature Summary
    106
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000025856 Ensembl Gene Model | MGI Sequence Detail 21357 C57BL/6J ±  kb
    transcript ENSMUST00000046901 Ensembl | MGI Sequence Detail 1543 Not Applicable  
    polypeptide ENSMUSP00000038870 Ensembl | MGI Sequence Detail 211 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      Genomic 4
      cDNA 18
      Primer pair 11
      Other 10

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13211
    References
    more
    • Summaries
      All 211
      Developmental Gene Expression 106
      Gene Ontology 22
      Phenotypes 29
    • Earliest
      J:20706 Cochran BH, et al., Expression of the c-fos gene and of an fos-related gene is stimulated by platelet-derived growth factor [published erratum appears in Science 1986 Apr 18;232(4748):307]. Science. 1984 Nov 30;226(4678):1080-2
    • Latest
      J:353621 Patel VN, et al., Specific 3-O-sulfated heparan sulfate domains regulate salivary gland basement membrane metabolism and epithelial differentiation. Nat Commun. 2024 Aug 31;15(1):7584
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory