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Phka2 Gene Detail
Summary
  • Symbol
    Phka2
  • Name
    phosphorylase kinase alpha 2
  • Synonyms
    6330505C01Rik, k, Phk
  • Feature Type
    protein coding gene
  • IDs
    MGI:97577
    NCBI Gene: 110094
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    ChrX:159285162-159381874 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome X, 73.95 cM, cytoband F3-F4
  • Mapping Data
    5 experiments
Strain
Comparison
more
  • SNPs within 2kb
    1790 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97577
 protein coding gene ChrX:159284900-159384772 (+)
129S1/SvImJ MGP_129S1SvImJ_G0036231
 protein coding gene ChrX:158435237-158531676 (+)
A/J MGP_AJ_G0036201
 protein coding gene ChrX:157697686-157782982 (+)
AKR/J MGP_AKRJ_G0036129
 protein coding gene ChrX:162693155-162791832 (+)
BALB/cJ MGP_BALBcJ_G0036194
 protein coding gene ChrX:155770923-155863429 (+)
C3H/HeJ MGP_C3HHeJ_G0035900
 protein coding gene ChrX:158834819-158923714 (+)
C57BL/6NJ MGP_C57BL6NJ_G0036716
 protein coding gene ChrX:163149170-163246897 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0033538
 protein coding gene ChrX:148931033-149012146 (+)
CAST/EiJ MGP_CASTEiJ_G0035189
 protein coding gene ChrX:137859340-137942480 (+)
CBA/J MGP_CBAJ_G0035875
 protein coding gene ChrX:167792623-167889476 (+)
DBA/2J MGP_DBA2J_G0036041
 protein coding gene ChrX:156657797-156751099 (+)
FVB/NJ MGP_FVBNJ_G0035972
 protein coding gene ChrX:155774814-155861215 (+)
LP/J MGP_LPJ_G0036126
 protein coding gene ChrX:159611869-159707085 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0036004
 protein coding gene ChrX:176488785-176596179 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0036757
 protein coding gene ChrX:157987584-158078731 (+)
PWK/PhJ MGP_PWKPhJ_G0034887
 protein coding gene ChrX:134716267-134803293 (+)
SPRET/EiJ MGP_SPRETEiJ_G0034708
 protein coding gene ChrX:138260133-138352756 (+)
WSB/EiJ MGP_WSBEiJ_G0035324
 protein coding gene ChrX:155936046-156031486 (+)



Homology
more
  • Human Ortholog
    PHKA2, phosphorylase kinase regulatory subunit alpha 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PHKA2, phosphorylase kinase regulatory subunit alpha 2
  • Synonyms
    GSD9A, PHK, PYK, PYKL, XLG, XLG2
  • Links
    NCBI Gene ID: 5256
    neXtProt AC: NX_P46019
    UniProt: P46019

  • Chr Location
    Xp22.13; chrX:18892298-18984114 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human PHKA2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    6
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    870
  • Tissues
    137
  • cDNA Data
    17
  • Literature Summary
    4
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000031295 Ensembl Gene Model | MGI Sequence Detail 96713 C57BL/6J ±  kb
transcript ENSMUST00000033652 Ensembl | MGI Sequence Detail 4133 Not Applicable  
polypeptide ENSMUSP00000033652 Ensembl | MGI Sequence Detail 1235 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000012659 phosphorylase b kinase regulatory subunit alpha, liver isoform
    (term hierarchy)
  • EC
    2.7.1.38
  • InterPro Domains
    IPR011613 GH15-like domain
    IPR045583 Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain
    IPR008734 Phosphorylase kinase alpha/beta subunit
    IPR012341 Six-hairpin glycosidase-like superfamily
    IPR008928 Six-hairpin glycosidase superfamily
Molecular
Reagents
less
  • All nucleic 20
    cDNA 18
    Primer pair 2

    Microarray probesets 4
Other
Accession IDs
less
MGD-MRK-11547, MGD-MRK-13293, MGD-MRK-13296, MGI:1923403, MGI:97575
References
more
  • Summaries
    All 43
    Developmental Gene Expression 4
    Gene Ontology 6
    Phenotypes 7
  • Earliest
    J:5367 Huijing F, et al., Location of phosphorylase kinase (Phk) in the mouse X chromosome. Biochem Genet. 1973 Jun;9(2):193-6
  • Latest
    J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory