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Pnmt Gene Detail
Summary
  • Symbol
    Pnmt
  • Name
    phenylethanolamine-N-methyltransferase
  • Synonyms
    Pent
  • Feature Type
    protein coding gene
  • IDs
    MGI:97724
    NCBI Gene: 18948
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:98277449-98279006 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 61.75 cM, cytoband D
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    123 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97724
 protein coding gene Chr11:98277276-98279007 (+)
129S1/SvImJ MGP_129S1SvImJ_G0019057
 protein coding gene Chr11:100927211-100928948 (+)
A/J MGP_AJ_G0019025
 protein coding gene Chr11:96733175-96734906 (+)
AKR/J MGP_AKRJ_G0018995
 protein coding gene Chr11:99727805-99729536 (+)
BALB/cJ MGP_BALBcJ_G0018998
 protein coding gene Chr11:97225288-97227019 (+)
C3H/HeJ MGP_C3HHeJ_G0018812
 protein coding gene Chr11:99861703-99863440 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019451
 protein coding gene Chr11:104007830-104009561 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0017082
 protein coding gene Chr11:94172821-94174557 (+)
CAST/EiJ MGP_CASTEiJ_G0018366
 protein coding gene Chr11:100736578-100740729 (+)
CBA/J MGP_CBAJ_G0018783
 protein coding gene Chr11:108315947-108317678 (+)
DBA/2J MGP_DBA2J_G0018891
 protein coding gene Chr11:96275493-96277483 (+)
FVB/NJ MGP_FVBNJ_G0018880
 protein coding gene Chr11:95783629-95785366 (+)
LP/J MGP_LPJ_G0018961
 protein coding gene Chr11:101405338-101407075 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018907
 protein coding gene Chr11:108118841-108120572 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019491
 protein coding gene Chr11:100055862-100057599 (+)
PWK/PhJ MGP_PWKPhJ_G0018138
 protein coding gene Chr11:97282139-97283843 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017928
 protein coding gene Chr11:99762472-99764216 (+)
WSB/EiJ MGP_WSBEiJ_G0018416
 protein coding gene Chr11:99968609-99970341 (+)



Homology
more
  • Human Ortholog
    PNMT, phenylethanolamine N-methyltransferase
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PNMT, phenylethanolamine N-methyltransferase
  • Synonyms
    PENT, PNMTase
  • Links
    NCBI Gene ID: 5409
    neXtProt AC: NX_P11086
    UniProt: P11086

  • Chr Location
    17q12; chr17:39667981-39670475 (+)  GRCh38
Human Diseases
more
  • Diseases
    3 with human PNMT associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 4 alleles in 4 genetic backgrounds
    33 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice lack adrenal epinephrine and have increased adrenal norepinephrine levels but are viable and fertile.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    15
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    856
  • Tissues
    124
  • cDNA Data
    9
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 18948 NCBI Gene Model | MGI Sequence Detail 1558 C57BL/6J ±  kb
    transcript NM_008890 RefSeq | MGI Sequence Detail 980 C57BL/6  
    polypeptide P40935 UniProt | EBI | MGI Sequence Detail 295 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      Genomic 3
      cDNA 10
      Primer pair 2

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13230, MGD-MRK-13546
    References
    more
    • Summaries
      All 93
      Developmental Gene Expression 31
      Gene Ontology 6
      Phenotypes 33
    • Earliest
      J:1117 Morita S, et al., Organization and complete nucleotide sequence of the gene encoding mouse phenylethanolamine N-methyltransferase. Brain Res Mol Brain Res. 1992 May;13(4):313-9
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory