About   Help   FAQ
Ptn Gene Detail
Summary
  • Symbol
    Ptn
  • Name
    pleiotrophin
  • Synonyms
    HB-GAM, HBGF-8, HBNF, heparin-binding growth-associated molecule, heparin-binding growth factor 8, Osf-1, Osf1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97804
    NCBI Gene: 19242
  • Alliance
    gene page
  • Transcription Start Sites
    23 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:36691863-36787114 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 15.48 cM
  • Mapping Data
    15 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2662 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    3
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97804
 protein coding gene Chr6:36691863-36787155 (-)
129S1/SvImJ MGP_129S1SvImJ_G0030574
 protein coding gene Chr6:34889503-34990942 (-)
A/J MGP_AJ_G0030547
 protein coding gene Chr6:33389148-33489112 (-)
AKR/J MGP_AKRJ_G0030474
 protein coding gene Chr6:34466886-34562018 (-)
BALB/cJ MGP_BALBcJ_G0030557
 protein coding gene Chr6:33586968-33684298 (-)
C3H/HeJ MGP_C3HHeJ_G0030270
 protein coding gene Chr6:34472440-34579774 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031011
 protein coding gene Chr6:35768449-35869204 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028223
 protein coding gene Chr6:31333832-31424971 (-)
CAST/EiJ MGP_CASTEiJ_G0029672
 protein coding gene Chr6:34299244-34405307 (-)
CBA/J MGP_CBAJ_G0030248
 protein coding gene Chr6:37156628-37258986 (-)
DBA/2J MGP_DBA2J_G0030392
 protein coding gene Chr6:33231870-33332230 (-)
FVB/NJ MGP_FVBNJ_G0030346
 protein coding gene Chr6:33026188-33124239 (-)
LP/J MGP_LPJ_G0030479
 protein coding gene Chr6:34986474-35094476 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0030382
 protein coding gene Chr6:39555761-39672289 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031041
 protein coding gene Chr6:34369255-34471115 (-)
PWK/PhJ MGP_PWKPhJ_G0029386
 protein coding gene Chr6:32836743-32934214 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029222
 protein coding gene Chr6:34042270-34141944 (-)
WSB/EiJ MGP_WSBEiJ_G0029748
 protein coding gene Chr6:34313454-34421343 (-)



Homology
more
  • Human Ortholog
    PTN, pleiotrophin
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTN, pleiotrophin
  • Synonyms
    HARP, HBBM, HB-GAM, HBGF-8, HBGF8, HBNF, HBNF-1, NEGF1, OSF-1
  • Links
    NCBI Gene ID: 5764
    neXtProt AC: NX_P21246
    UniProt: P21246

  • Chr Location
    7q33; chr7:137227341-137343774 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human PTN associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 2 genetic backgrounds
    23 phenotypes from multigenic genotypes
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit enhanced long term potentiation, an impairment of spatial learning, and increased anxiety. The brains of mutant mice are morphologically normal.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    101
  • GO References
    20
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1213
  • Tissues
    324
  • cDNA Data
    133
  • Literature Summary
    46
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19242 NCBI Gene Model | MGI Sequence Detail 95252 C57BL/6J ±  kb
    transcript NM_008973 RefSeq | MGI Sequence Detail 1588 ZRU/MplStud  
    polypeptide P63089 UniProt | EBI | MGI Sequence Detail 168 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000013438 pleiotrophin
      (term hierarchy)
    • InterPro Domains
      IPR000762 Midkine heparin-binding growth factor
      IPR020090 Pleiotrophin/Midkine, C-terminal domain
      IPR038130 Pleiotrophin/Midkine, C-terminal domain superfamily
      IPR020091 Pleiotrophin/Midkine disulphide-rich domain superfamily
      IPR020092 Pleiotrophin/Midkine heparin-binding growth factor, conserved site
      IPR020089 Pleiotrophin/Midkine, N-terminal domain
      IPR037122 Pleiotrophin/Midkine, N-terminal domain superfamily
    Molecular
    Reagents
    less
    • All nucleic 153
      Genomic 4
      cDNA 135
      Primer pair 10
      Other 4

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13056, MGD-MRK-13057, MGD-MRK-13672
    References
    more
    • Summaries
      All 148
      Developmental Gene Expression 46
      Gene Ontology 20
      Phenotypes 39
    • Earliest
      J:10881 Tezuka K, et al., Isolation of mouse and human cDNA clones encoding a protein expressed specifically in osteoblasts and brain tissues. Biochem Biophys Res Commun. 1990 Nov 30;173(1):246-51
    • Latest
      J:340716 Li H, et al., Pleiotrophin ameliorates age-induced adult hippocampal neurogenesis decline and cognitive dysfunction. Cell Rep. 2023 Aug 22;42(9):113022
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory