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Ptprb Gene Detail
Summary
  • Symbol
    Ptprb
  • Name
    protein tyrosine phosphatase receptor type B
  • Synonyms
    3230402H02Rik, VE-PTP
  • Feature Type
    protein coding gene
  • IDs
    MGI:97809
    NCBI Gene: 19263
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:116111428-116225440 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 64.68 cM, cytoband D2
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3620 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97809
 protein coding gene Chr10:116111407-116225443 (+)
129S1/SvImJ MGP_129S1SvImJ_G0017744
 protein coding gene Chr10:119062780-119158258 (+)
A/J MGP_AJ_G0017720
 protein coding gene Chr10:114488765-114578770 (+)
AKR/J MGP_AKRJ_G0017682
 protein coding gene Chr10:117787275-117895841 (+)
BALB/cJ MGP_BALBcJ_G0017683
 protein coding gene Chr10:114887949-114980411 (+)
C3H/HeJ MGP_C3HHeJ_G0017508
 protein coding gene Chr10:118031441-118125112 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018140
 protein coding gene Chr10:123199441-123301595 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0015820
 protein coding gene Chr10:109094240-109179492 (+)
CAST/EiJ MGP_CASTEiJ_G0017070
 protein coding gene Chr10:118307435-118402088 (+)
CBA/J MGP_CBAJ_G0017477
 protein coding gene Chr10:128015882-128120446 (+)
DBA/2J MGP_DBA2J_G0017582
 protein coding gene Chr10:113631990-113720081 (+)
FVB/NJ MGP_FVBNJ_G0017577
 protein coding gene Chr10:112588106-112675937 (+)
LP/J MGP_LPJ_G0017657
 protein coding gene Chr10:119652291-119745870 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0017606
 protein coding gene Chr10:130929949-131026479 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018178
 protein coding gene Chr10:117868185-117962701 (+)
PWK/PhJ MGP_PWKPhJ_G0016852
 protein coding gene Chr10:113711608-113802886 (+)
SPRET/EiJ MGP_SPRETEiJ_G0016642
 protein coding gene Chr10:116673368-116772153 (+)
WSB/EiJ MGP_WSBEiJ_G0017130
 protein coding gene Chr10:118044580-118145338 (+)



Homology
more
  • Human Ortholog
    PTPRB, protein tyrosine phosphatase receptor type B
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PTPRB, protein tyrosine phosphatase receptor type B
  • Synonyms
    HPTPB, HPTP-BETA, PTPB, R-PTP-BETA, VEPTP
  • Links
    NCBI Gene ID: 5787
    neXtProt AC: NX_P23467
    UniProt: P23467

  • Chr Location
    12q15; chr12:70515870-70637440 (-)  GRCh38
Human Diseases
more
  • Diseases
    7 with human PTPRB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    21 phenotypes from 3 alleles in 3 genetic backgrounds
    3 phenotypes from multigenic genotypes
    4 images
    22 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit embryonic lethality at E10, impaired vascular maintenace and remodeling, heart defects and abnormal yolk sac vasculature.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    18
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    823
  • Tissues
    50
  • cDNA Data
    13
  • Literature Summary
    10
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020154 Ensembl Gene Model | MGI Sequence Detail 114013 C57BL/6J ±  kb
    transcript ENSMUST00000218553 Ensembl | MGI Sequence Detail 7016 Not Applicable  
    polypeptide ENSMUSP00000151821 Ensembl | MGI Sequence Detail 2285 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 20
      cDNA 16
      Primer pair 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-13678, MGI:1924822
    References
    more
    • Summaries
      All 67
      Developmental Gene Expression 10
      Gene Ontology 13
      Phenotypes 22
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:325730 Ahuja N, et al., Endothelial Cyp26b1 restrains murine heart valve growth during development. Dev Biol. 2022 Jun;486:81-95
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory