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Pvalb Gene Detail
Summary
  • Symbol
    Pvalb
  • Name
    parvalbumin
  • Synonyms
    Parv, PV, Pva
  • Feature Type
    protein coding gene
  • IDs
    MGI:97821
    NCBI Gene: 19293
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr15:78075314-78090600 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 15, 36.93 cM, cytoband E
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    480 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    5
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97821
 protein coding gene Chr15:78075312-78090600 (-)
129S1/SvImJ MGP_129S1SvImJ_G0022037
 protein coding gene Chr15:78353479-78368803 (-)
A/J MGP_AJ_G0021997
 protein coding gene Chr15:75623879-75639119 (-)
AKR/J MGP_AKRJ_G0021974
 protein coding gene Chr15:77699949-77715196 (-)
BALB/cJ MGP_BALBcJ_G0022005
 protein coding gene Chr15:75639448-75654730 (-)
C3H/HeJ MGP_C3HHeJ_G0021776
 protein coding gene Chr15:77778109-77793417 (-)
C57BL/6NJ MGP_C57BL6NJ_G0022447
 protein coding gene Chr15:81427158-81442770 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0019976
 protein coding gene Chr15:72189477-72204836 (-)
CAST/EiJ MGP_CASTEiJ_G0021296
 protein coding gene Chr15:78390644-78405911 (-)
CBA/J MGP_CBAJ_G0021741
 protein coding gene Chr15:83940288-83955596 (-)
DBA/2J MGP_DBA2J_G0021869
 protein coding gene Chr15:75120507-75135711 (-)
FVB/NJ MGP_FVBNJ_G0021848
 protein coding gene Chr15:74113149-74129404 (-)
LP/J MGP_LPJ_G0021938
 protein coding gene Chr15:78523222-78538456 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0021868
 protein coding gene Chr15:89135890-89152032 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0022461
 protein coding gene Chr15:77806831-77822063 (-)
PWK/PhJ MGP_PWKPhJ_G0021038
 protein coding gene Chr15:75104990-75120380 (-)
SPRET/EiJ MGP_SPRETEiJ_G0020874
 protein coding gene Chr15:77569258-77584496 (-)
WSB/EiJ MGP_WSBEiJ_G0021349
 protein coding gene Chr15:78125274-78140538 (-)



Homology
more
  • Human Ortholog
    PVALB, parvalbumin
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    PVALB, parvalbumin
  • Synonyms
    D22S749
  • Links
    NCBI Gene ID: 5816
    neXtProt AC: NX_P20472
    UniProt: P20472

  • Chr Location
    22q12.3; chr22:36800684-36819499 (-)  GRCh38
Human Diseases
less
  • Mutations/Alleles
    1 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 6 alleles in 7 genetic backgrounds
    44 phenotypes from multigenic genotypes
    1195 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for deletion of this marker show slower cotraction-relaxation of fast twitch muscle and and increased force generation. Abnormalities are also reported in Purkinje cell morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    16
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1327
  • Tissues
    252
  • cDNA Data
    86
  • Literature Summary
    472
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000005716 Ensembl Gene Model | MGI Sequence Detail 15287 C57BL/6J ±  kb
transcript ENSMUST00000120592 Ensembl | MGI Sequence Detail 953 Not Applicable  
polypeptide ENSMUSP00000112598 Ensembl | MGI Sequence Detail 110 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 115
    Genomic 13
    cDNA 90
    Primer pair 8
    Other 4

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-13692
References
more
  • Summaries
    All 1724
    Developmental Gene Expression 472
    Diseases 3
    Gene Ontology 11
    Phenotypes 1195
  • Earliest
    J:7524 Stuhlfauth I, et al., Calcium-binding protein, parvalbumin, is reduced in mutant mammalian muscle with abnormal contractile properties. Proc Natl Acad Sci U S A. 1984 Aug;81(15):4814-8
  • Latest
    J:358243 Liu M, et al., Complexin-1 enhances ultrasound neurotransmission in the mammalian auditory pathway. Nat Genet. 2024 Jul;56(7):1503-1515
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/19/2024
MGI 6.24 		The Jackson Laboratory