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Slc20a2 Gene Detail
Summary
  • Symbol
    Slc20a2
  • Name
    solute carrier family 20, member 2
  • Synonyms
    MolPit2, Pit-2, PiT-2, Ram-1, Ram1
  • Feature Type
    protein coding gene
  • IDs
    MGI:97851
    NCBI Gene: 20516
  • Alliance
    gene page
  • Transcription Start Sites
    11 TSS
Location &
Maps
more
  • Sequence Map
    Chr8:22966804-23059628 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 8, 11.42 cM
  • Mapping Data
    6 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2578 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97851
 protein coding gene Chr8:22966771-23059632 (+)
129S1/SvImJ MGP_129S1SvImJ_G0033453
 protein coding gene Chr8:20330456-20421763 (+)
A/J MGP_AJ_G0033433
 protein coding gene Chr8:19669868-19757593 (+)
AKR/J MGP_AKRJ_G0033358
 protein coding gene Chr8:20318048-20403529 (+)
BALB/cJ MGP_BALBcJ_G0033429
 protein coding gene Chr8:19794205-19880872 (+)
C3H/HeJ MGP_C3HHeJ_G0033143
 protein coding gene Chr8:20576797-20603308 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033945
 protein coding gene Chr8:21188748-21283290 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030898
 protein coding gene Chr8:17001766-17087523 (+)
CAST/EiJ MGP_CASTEiJ_G0032469
 protein coding gene Chr8:19930700-20020387 (+)
CBA/J MGP_CBAJ_G0033118
 protein coding gene Chr8:22106319-22132750 (+)
DBA/2J MGP_DBA2J_G0033273
 protein coding gene Chr8:19638616-19724465 (+)
FVB/NJ MGP_FVBNJ_G0033217
 protein coding gene Chr8:19431954-19517767 (+)
LP/J MGP_LPJ_G0033362
 protein coding gene Chr8:20329205-20418613 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0033260
 protein coding gene Chr8:21689161-21715598 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033964
 protein coding gene Chr8:20223138-20311295 (+)
PWK/PhJ MGP_PWKPhJ_G0032181
 protein coding gene Chr8:19285929-19323627 (+)
SPRET/EiJ MGP_SPRETEiJ_G0032014
 protein coding gene Chr8:19669706-19696392 (+)
WSB/EiJ MGP_WSBEiJ_G0032585
 protein coding gene Chr8:20482481-20508942 (+)



Homology
more
  • Human Ortholog
    SLC20A2, solute carrier family 20 member 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SLC20A2, solute carrier family 20 member 2
  • Synonyms
    GLVR-2, GLVR2, IBGC1, IBGC2, IBGC3, MLVAR, PIT-2, PIT2, Ram-1, RAM1
  • Links
    NCBI Gene ID: 6575
    neXtProt AC: NX_Q08357
    UniProt: Q08357

  • Chr Location
    8p11.21; chr8:42416475-42541954 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Slc20a2 mouse models; 1 with human SLC20A2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    44 phenotypes from 2 alleles in 3 genetic backgrounds
    37 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit brain calcifications in the thalamus, basal ganglia and cerebral cortex, microgliosis, and a high inorganic phosphate concentration [Pi] in cerebrospinal fluid.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    17
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    769
  • Tissues
    36
  • cDNA Data
    10
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000037656 Ensembl Gene Model | MGI Sequence Detail 92825 C57BL/6J ±  kb
    transcript ENSMUST00000067786 Ensembl | MGI Sequence Detail 3566 Not Applicable  
    polypeptide ENSMUSP00000065935 Ensembl | MGI Sequence Detail 656 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      cDNA 11
      Primer pair 5
      Other 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13759, MGD-MRK-13760
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 8
      Diseases 1
      Gene Ontology 10
      Phenotypes 37
    • Earliest
      J:5854 Gazdar AF, et al., Identification of mouse chromosomes required for murine leukemia virus replication. Cell. 1977 Aug;11(4):949-56
    • Latest
      J:357393 Cheng X, et al., Astrocytes modulate brain phosphate homeostasis via polarized distribution of phosphate uptake transporter PiT2 and exporter XPR1. Neuron. 2024 Jul 9;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory