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Rarb Gene Detail
Summary
  • Symbol
    Rarb
  • Name
    retinoic acid receptor, beta
  • Synonyms
    Hap, RAR beta 2, RARbeta2
  • Feature Type
    protein coding gene
  • IDs
    MGI:97857
    NCBI Gene: 218772
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:5650540-6038924 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 7.08 cM, cytoband A1-A3
  • Mapping Data
    21 experiments
Strain
Comparison
more
  • SNPs within 2kb
    10903 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    8
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97857
 protein coding gene Chr14:5387365-6038924 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021017
 protein coding gene Chr14:9069533-9213570 (-)
A/J MGP_AJ_G0020965
 protein coding gene Chr14:8799394-8945805 (-)
AKR/J MGP_AKRJ_G0020942
 protein coding gene Chr14:9029258-9182710 (-)
BALB/cJ MGP_BALBcJ_G0020968
 protein coding gene Chr14:8833926-8978892 (-)
C3H/HeJ MGP_C3HHeJ_G0020752
 protein coding gene Chr14:9136005-9283340 (-)
C57BL/6NJ MGP_C57BL6NJ_G0021401
 protein coding gene Chr14:9327103-9479579 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0018970
 protein coding gene Chr14:9411797-9544050 (-)
CAST/EiJ MGP_CASTEiJ_G0020275
 protein coding gene Chr14:9020766-9166249 (-)
CBA/J MGP_CBAJ_G0020718
 protein coding gene Chr14:9749310-9914573 (-)
DBA/2J MGP_DBA2J_G0020842
 protein coding gene Chr14:8731790-8871806 (-)
FVB/NJ MGP_FVBNJ_G0020824
 protein coding gene Chr14:8564941-8704241 (-)
LP/J MGP_LPJ_G0020917
 protein coding gene Chr14:9120879-9267675 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0020850
 protein coding gene Chr14:9623745-9779143 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0021434
 protein coding gene Chr14:8902990-9052539 (-)
PWK/PhJ MGP_PWKPhJ_G0020026
 protein coding gene Chr14:8756196-8899642 (-)
SPRET/EiJ MGP_SPRETEiJ_G0019847
 protein coding gene Chr14:9125829-9269627 (-)
WSB/EiJ MGP_WSBEiJ_G0020332
 protein coding gene Chr14:8951737-9109543 (-)



Homology
more
  • Human Ortholog
    RARB, retinoic acid receptor beta
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RARB, retinoic acid receptor beta
  • Synonyms
    HAP, MCOPS12, NR1B2, RARbeta, RARbeta1, RRB2
  • Links
    NCBI Gene ID: 5915
    neXtProt AC: NX_P10826
    UniProt: P10826

  • Chr Location
    3p24.2; chr3:24687887-25597932 (+)  GRCh38
Human Diseases
more
  • Diseases
    5 with human RARB associations

Human Disease Mouse Models
      
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    38 phenotypes from 5 alleles in 5 genetic backgrounds
    127 phenotypes from multigenic genotypes
    64 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for a targeted null mutation exhibit reduced growth, but are otherwise normal. Rarb/Rara double knockouts exhibit impaired vitamin A signaling and develop urogenital malformations, including renal hypoplasia and hydronephrosis.
Gene Ontology
(GO)
Classifications
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  • All GO Annotations
    65
  • GO References
    23
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1741
  • Tissues
    496
  • cDNA Data
    64
  • Literature Summary
    160
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000017491 Ensembl Gene Model | MGI Sequence Detail 388385 C57BL/6J ±  kb
    transcript ENSMUST00000063750 Ensembl | MGI Sequence Detail 3108 Not Applicable  
    polypeptide ENSMUSP00000067694 Ensembl | MGI Sequence Detail 448 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 132
      Genomic 5
      cDNA 81
      Primer pair 21
      Other 25

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-10620, MGD-MRK-13767
    References
    more
    • Summaries
      All 325
      Developmental Gene Expression 160
      Gene Ontology 23
      Phenotypes 64
    • Earliest
      J:22881 de The H, et al., A novel steroid thyroid hormone receptor-related gene inappropriately expressed in human hepatocellular carcinoma. Nature. 1987 Dec 17-23;330(6149):667-70
    • Latest
      J:350460 Soussi G, et al., TBX3 is essential for establishment of the posterior boundary of anterior genes and upregulation of posterior genes together with HAND2 during the onset of limb bud development. Development. 2024 Jun 1;151(11)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory