About   Help   FAQ
Reg2 Gene Detail
Summary
  • Symbol
    Reg2
  • Name
    regenerating islet-derived 2
  • Synonyms
    pancreatic thread protein
  • Feature Type
    protein coding gene
  • IDs
    MGI:97896
    NCBI Gene: 19693
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:78382138-78385082 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 34.77 cM, cytoband C
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    160 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97896
 protein coding gene Chr6:78372606-78385089 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030896
 protein coding gene Chr6:79220278-79223227 (+)
A/J MGP_AJ_G0030865
 protein coding gene Chr6:76146551-76149499 (+)
AKR/J MGP_AKRJ_G0030793
 protein coding gene Chr6:78392272-78395220 (+)
BALB/cJ MGP_BALBcJ_G0030875
 protein coding gene Chr6:76210511-76213459 (+)
C3H/HeJ MGP_C3HHeJ_G0030835
 protein coding gene Chr6:105893956-105896904 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031335
 protein coding gene Chr6:81337950-81340898 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028522
 protein coding gene Chr6:74935536-74938548 (+)
CAST/EiJ MGP_CASTEiJ_G0029983
 protein coding gene Chr6:78332427-78335379 (+)
CBA/J MGP_CBAJ_G0030562
 protein coding gene Chr6:84547958-84550906 (+)
DBA/2J MGP_DBA2J_G0030715
 protein coding gene Chr6:75514153-75517101 (+)
FVB/NJ MGP_FVBNJ_G0030668
 protein coding gene Chr6:74787620-74790568 (+)
LP/J MGP_LPJ_G0030794
 protein coding gene Chr6:79130046-79132995 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030704
 protein coding gene Chr6:88545565-88548512 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031359
 protein coding gene Chr6:78220672-78223607 (+)
PWK/PhJ MGP_PWKPhJ_G0029699
 protein coding gene Chr6:74464909-74467845 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029527
 protein coding gene Chr6:77052170-77055105 (+)
WSB/EiJ MGP_WSBEiJ_G0030065
 protein coding gene Chr6:78632993-78635941 (+)



Homology
more
  • Human Ortholog
    REG1A, regenerating family member 1 alpha
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    REG1A, regenerating family member 1 alpha
  • Synonyms
    ICRF, P19, PSP, PSPS, PSPS1, PTP, REG
  • Links
    NCBI Gene ID: 5967
    neXtProt AC: NX_P05451
    UniProt: P05451

  • Chr Location
    2p12; chr2:79120362-79123409 (+)  GRCh38
  • Human Ortholog
    REG1B, regenerating family member 1 beta
  • Synonyms
    PSPS2, REGH, REGI-BETA, REGL
  • Links
    NCBI Gene ID: 5968
    neXtProt AC: NX_P48304
    UniProt: P48304

  • Chr Location
    2p12; chr2:79085023-79088019 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human REG1A associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    20 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit impaired suckling, delayed hypoglossal myelination and reduced liver regeneration following partial hepatectomy.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    793
  • Tissues
    15
  • cDNA Data
    32
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 19693 NCBI Gene Model | MGI Sequence Detail 2945 C57BL/6J ±  kb
    transcript NM_009043 RefSeq | MGI Sequence Detail 710 C57BL/6  
    polypeptide Q08731 UniProt | EBI | MGI Sequence Detail 173 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 1
      cDNA 32
      Primer pair 2
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-13831
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Gene Ontology 6
      Phenotypes 20
    • Earliest
      J:13303 Unno M, et al., Structure, chromosomal localization, and expression of mouse reg genes, reg I and reg II. A novel type of reg gene, reg II, exists in the mouse genome. J Biol Chem. 1993 Jul 25;268(21):15974-82
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory