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Rlbp1 Gene Detail
Summary
  • Symbol
    Rlbp1
  • Name
    retinaldehyde binding protein 1
  • Synonyms
    3110056M11Rik, CRALBP
  • Feature Type
    protein coding gene
  • IDs
    MGI:97930
    NCBI Gene: 19771
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:79024618-79036796 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 45.00 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    414 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97930
 protein coding gene Chr7:79024613-79041989 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032387
 protein coding gene Chr7:81248754-81267687 (-)
A/J MGP_AJ_G0032366
 protein coding gene Chr7:79381066-79393288 (-)
AKR/J MGP_AKRJ_G0032302
 protein coding gene Chr7:81078406-81090497 (-)
BALB/cJ MGP_BALBcJ_G0032378
 protein coding gene Chr7:79079097-79091477 (-)
C3H/HeJ MGP_C3HHeJ_G0032091
 protein coding gene Chr7:81745030-81760432 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032870
 protein coding gene Chr7:84452088-84468811 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029878
 protein coding gene Chr7:81924705-81937228 (-)
CAST/EiJ MGP_CASTEiJ_G0031419
 protein coding gene Chr7:72612479-72625616 (-)
CBA/J MGP_CBAJ_G0032057
 protein coding gene Chr7:87275517-87293129 (-)
DBA/2J MGP_DBA2J_G0032212
 protein coding gene Chr7:77959484-77971675 (-)
FVB/NJ MGP_FVBNJ_G0032167
 protein coding gene Chr7:77869649-77882951 (-)
LP/J MGP_LPJ_G0032293
 protein coding gene Chr7:82508502-82520546 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0032204
 protein coding gene Chr7:87470029-87484686 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032888
 protein coding gene Chr7:80533147-80545518 (-)
PWK/PhJ MGP_PWKPhJ_G0031139
 protein coding gene Chr7:71123215-71135796 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030980
 protein coding gene Chr7:67522934-67535889 (-)
WSB/EiJ MGP_WSBEiJ_G0031537
 protein coding gene Chr7:80852463-80868160 (-)



Homology
more
  • Human Ortholog
    RLBP1, retinaldehyde binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RLBP1, retinaldehyde binding protein 1
  • Synonyms
    CRALBP
  • Links
    NCBI Gene ID: 6017
    neXtProt AC: NX_P12271
    UniProt: P12271

  • Chr Location
    15q26.1; chr15:89209869-89221614 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Rlbp1 mouse models; 5 with human RLBP1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    7 phenotypes from 2 alleles in 2 genetic backgrounds
    35 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display delayed dark adaptation as well as reduced retinal degeneration.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    851
  • Tissues
    46
  • cDNA Data
    31
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000039194 Ensembl Gene Model | MGI Sequence Detail 12179 C57BL/6J ±  kb
    transcript ENSMUST00000179243 Ensembl | MGI Sequence Detail 2142 Not Applicable  
    polypeptide ENSMUSP00000137143 Ensembl | MGI Sequence Detail 317 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 38
      cDNA 32
      Primer pair 3
      Other 3

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-13896, MGI:1920482
    References
    more
    • Summaries
      All 108
      Developmental Gene Expression 44
      Diseases 1
      Gene Ontology 6
      Phenotypes 35
    • Earliest
      J:6901 Saari JC, et al., Identification of the endogenous retinoids associated with three cellular retinoid-binding proteins from bovine retina and retinal pigment epithelium. J Biol Chem. 1982 Nov 25;257(22):13329-33
    • Latest
      J:349815 Bassetto M, et al., Dominant role for pigment epithelial CRALBP in supplying visual chromophore to photoreceptors. Cell Rep. 2024 May 28;43(5):114143
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory