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Rom1 Gene Detail
Summary
  • Symbol
    Rom1
  • Name
    rod outer segment membrane protein 1
  • Synonyms
    M101156, Rgsc1156, Rom-1, Tspan23
  • Feature Type
    protein coding gene
  • IDs
    MGI:97998
    NCBI Gene: 19881
  • Alliance
    gene page
  • Transcription Start Sites
    2 TSS
Location &
Maps
more
  • Sequence Map
    Chr19:8904755-8906720 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 6.03 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    92 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_97998
 protein coding gene Chr19:8904746-8906720 (-)
129S1/SvImJ MGP_129S1SvImJ_G0024823
 protein coding gene Chr19:6215104-6217078 (-)
A/J MGP_AJ_G0024791
 protein coding gene Chr19:5880217-5882191 (-)
AKR/J MGP_AKRJ_G0024766
 protein coding gene Chr19:5978175-5980149 (-)
BALB/cJ MGP_BALBcJ_G0024791
 protein coding gene Chr19:5989451-5991425 (-)
C3H/HeJ MGP_C3HHeJ_G0024557
 protein coding gene Chr19:6066371-6068345 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025238
 protein coding gene Chr19:6350617-6352591 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022667
 protein coding gene Chr19:6137307-6139284 (-)
CAST/EiJ MGP_CASTEiJ_G0024030
 protein coding gene Chr19:5716056-5718030 (-)
CBA/J MGP_CBAJ_G0024531
 protein coding gene Chr19:6468449-6470423 (-)
DBA/2J MGP_DBA2J_G0024658
 protein coding gene Chr19:5715008-5716982 (-)
FVB/NJ MGP_FVBNJ_G0024625
 protein coding gene Chr19:5785256-5787230 (-)
LP/J MGP_LPJ_G0024745
 protein coding gene Chr19:6110840-6112814 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024652
 protein coding gene Chr19:6326706-6328680 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025287
 protein coding gene Chr19:6025740-6027714 (-)
PWK/PhJ MGP_PWKPhJ_G0023775
 protein coding gene Chr19:5387848-5389822 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023580
 protein coding gene Chr19:5636426-5638412 (-)
WSB/EiJ MGP_WSBEiJ_G0024092
 protein coding gene Chr19:5993342-5995316 (-)



Homology
more
  • Human Ortholog
    ROM1, retinal outer segment membrane protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ROM1, retinal outer segment membrane protein 1
  • Synonyms
    ROM, ROSP1, RP7, TSPAN23
  • Links
    NCBI Gene ID: 6094
    neXtProt AC: NX_Q03395
    UniProt: Q03395

  • Chr Location
    11q12.3; chr11:62611722-62615116 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human ROM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    11 phenotypes from 2 alleles in 3 genetic backgrounds
    12 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants exhibit large retinal discs, disorganized outer segments, gradual loss of rod photoreceptors by apoptosis, and diminished photo responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    4
  • cDNA Data
    71
  • Literature Summary
    15
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000071648 Ensembl Gene Model | MGI Sequence Detail 1966 C57BL/6J ±  kb
    transcript ENSMUST00000096242 Ensembl | MGI Sequence Detail 1517 Not Applicable  
    polypeptide ENSMUSP00000093961 Ensembl | MGI Sequence Detail 351 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 75
      Genomic 1
      cDNA 72
      Primer pair 1
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14007, MGD-MRK-14008, MGI:3814073
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 15
      Gene Ontology 9
      Phenotypes 12
    • Earliest
      J:2878 Bascom RA, et al., Localization of the photoreceptor gene ROM1 to human chromosome 11 and mouse chromosome 19: sublocalization to human 11q13 between PGA and PYGM. Am J Hum Genet. 1992 Nov;51(5):1028-35
    • Latest
      J:329268 Langouet M, et al., Mutations in BCOR, a co-repressor of CRX/OTX2, are associated with early-onset retinal degeneration. Sci Adv. 2022 Sep 9;8(36):eabh2868
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory