About   Help   FAQ
Rrm1 Gene Detail
Summary
  • Symbol
    Rrm1
  • Name
    ribonucleotide reductase M1
  • Synonyms
    RnrM1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98180
    NCBI Gene: 20133
  • Alliance
    gene page
  • Transcription Start Sites
    7 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:102090902-102118978 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 54.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    848 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98180
 protein coding gene Chr7:102090902-102118978 (+)
129S1/SvImJ MGP_129S1SvImJ_G0032608
 protein coding gene Chr7:105498433-105528192 (+)
A/J MGP_AJ_G0032584
 protein coding gene Chr7:102799543-102827147 (+)
AKR/J MGP_AKRJ_G0032520
 protein coding gene Chr7:105259238-105289795 (+)
BALB/cJ MGP_BALBcJ_G0032595
 protein coding gene Chr7:102501071-102528721 (+)
C3H/HeJ MGP_C3HHeJ_G0032309
 protein coding gene Chr7:105656893-105685091 (+)
C57BL/6NJ MGP_C57BL6NJ_G0033092
 protein coding gene Chr7:109456567-109489031 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0030086
 protein coding gene Chr7:105147294-105175426 (+)
CAST/EiJ MGP_CASTEiJ_G0031635
 protein coding gene Chr7:97206738-97237143 (+)
CBA/J MGP_CBAJ_G0032275
 protein coding gene Chr7:113292410-113332423 (+)
DBA/2J MGP_DBA2J_G0032427
 protein coding gene Chr7:101123624-101151082 (+)
FVB/NJ MGP_FVBNJ_G0032383
 protein coding gene Chr7:100906437-100934145 (+)
LP/J MGP_LPJ_G0032516
 protein coding gene Chr7:106804067-106833103 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0032417
 protein coding gene Chr7:114558158-114588040 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0033114
 protein coding gene Chr7:104546094-104573165 (+)
PWK/PhJ MGP_PWKPhJ_G0031353
 protein coding gene Chr7:94246655-94275006 (+)
SPRET/EiJ MGP_SPRETEiJ_G0031197
 protein coding gene Chr7:91835285-91862785 (+)
WSB/EiJ MGP_WSBEiJ_G0031752
 protein coding gene Chr7:105220341-105248906 (+)



Homology
more
  • Human Ortholog
    RRM1, ribonucleotide reductase catalytic subunit M1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    RRM1, ribonucleotide reductase catalytic subunit M1
  • Synonyms
    PEOB6, R1, RIR1, RR1
  • Links
    NCBI Gene ID: 6240
    neXtProt AC: NX_P23921
    UniProt: P23921

  • Chr Location
    11p15.4; chr11:4094685-4138932 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human RRM1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 2 alleles in 2 genetic backgrounds
    1 phenotype from multigenic genotypes
    26 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele exhibit embryonic letahlity before E3.5.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    51
  • GO References
    15
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1157
  • Tissues
    155
  • cDNA Data
    19
  • Literature Summary
    13
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 20133 NCBI Gene Model | MGI Sequence Detail 28077 C57BL/6J ±  kb
transcript NM_009103 RefSeq | MGI Sequence Detail 3997 ZRU/MplStud  
polypeptide P07742 UniProt | EBI | MGI Sequence Detail 792 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    5 Sequences
  • Protein Ontology
    PR:000014305 ribonucleoside-diphosphate reductase large subunit
    (term hierarchy)
  • EC
    1.17.4.1
  • InterPro Domains
    IPR005144 ATP-cone domain
    IPR039718 Ribonucleoside-diphosphate reductase large subunit
    IPR013346 Ribonucleotide reductase, class I, alpha subunit, C-terminal
    IPR000788 Ribonucleotide reductase large subunit, C-terminal
    IPR013509 Ribonucleotide reductase large subunit, N-terminal
    IPR008926 Ribonucleotide reductase R1 subunit, N-terminal
  • GlyGen
    P07742 3 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (2 sites)
Molecular
Reagents
less
  • All nucleic 30
    Genomic 8
    cDNA 20
    Primer pair 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-14209
References
more
  • Summaries
    All 82
    Developmental Gene Expression 13
    Gene Ontology 15
    Phenotypes 26
  • Earliest
    J:7868 Caras IW, et al., Cloned mouse ribonucleotide reductase subunit M1 cDNA reveals amino acid sequence homology with Escherichia coli and herpesvirus ribonucleotide reductases. J Biol Chem. 1985 Jun 10;260(11):7015-22
  • Latest
    J:358418 Tran P, et al., Altered dNTP pools accelerate tumor formation in mice. Nucleic Acids Res. 2024 Nov 11;52(20):12475-12486
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory