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Apcs Gene Detail
Summary
  • Symbol
    Apcs
  • Name
    amyloid P component, serum
  • Synonyms
    Sap
  • Feature Type
    protein coding gene
  • IDs
    MGI:98229
    NCBI Gene: 20219
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:172721528-172722516 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 80.33 cM
  • Mapping Data
    32 experiments
Strain
Comparison
more
  • SNPs within 2kb
    172 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    9
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98229
 protein coding gene Chr1:172721528-172722608 (-)
129S1/SvImJ MGP_129S1SvImJ_G0016797
 protein coding gene Chr1:178776802-178777882 (-)
A/J MGP_AJ_G0016776
 protein coding gene Chr1:171472207-171473287 (-)
AKR/J MGP_AKRJ_G0016742
 protein coding gene Chr1:176647673-176648753 (-)
BALB/cJ MGP_BALBcJ_G0016737
 protein coding gene Chr1:172009791-172010871 (-)
C3H/HeJ MGP_C3HHeJ_G0016561
 protein coding gene Chr1:177227085-177228165 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017199
 protein coding gene Chr1:184709144-184710224 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0014905
 protein coding gene Chr1:163145351-163146431 (-)
CAST/EiJ MGP_CASTEiJ_G0016141
 protein coding gene Chr1:176584517-176585597 (-)
CBA/J MGP_CBAJ_G0016535
 protein coding gene Chr1:191305646-191306726 (-)
DBA/2J MGP_DBA2J_G0016642
 protein coding gene Chr1:170390859-170391939 (-)
FVB/NJ MGP_FVBNJ_G0016639
 protein coding gene Chr1:168638427-168639507 (-)
LP/J MGP_LPJ_G0016713
 protein coding gene Chr1:179840331-179841411 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0016666
 protein coding gene Chr1:198505318-198506398 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017235
 protein coding gene Chr1:176540578-176541658 (-)
PWK/PhJ MGP_PWKPhJ_G0015927
 protein coding gene Chr1:169781327-169782407 (-)
SPRET/EiJ MGP_SPRETEiJ_G0015709
 protein coding gene Chr1:175485861-175486941 (-)
WSB/EiJ MGP_WSBEiJ_G0016203
 protein coding gene Chr1:176672375-176673455 (-)



Homology
more
  • Human Ortholog
    APCS, amyloid P component, serum
  • Vertebrate Orthologs
    7
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    APCS, amyloid P component, serum
  • Synonyms
    HEL-S-92n, PTX2, SAP
  • Links
    NCBI Gene ID: 325
    neXtProt AC: NX_P02743
    UniProt: P02743

  • Chr Location
    1q23.2; chr1:159587826-159588865 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human APCS associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    16 phenotypes from 2 alleles in 4 genetic backgrounds
    19 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit decreased antibody productions, increased autoimmune antibodies, reduced amyloidosis and glomerulonephrosis depending on strain background.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    27
  • GO References
    5
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    714
  • Tissues
    3
  • cDNA Data
    34
  • Literature Summary
    4
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20219 NCBI Gene Model | MGI Sequence Detail 989 C57BL/6J ±  kb
    transcript NM_011318 RefSeq | MGI Sequence Detail 879 ZRU/MplStud  
    polypeptide P12246 UniProt | EBI | MGI Sequence Detail 224 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 64
      Genomic 27
      cDNA 34
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14288
    References
    more
    • Summaries
      All 84
      Developmental Gene Expression 4
      Gene Ontology 5
      Phenotypes 19
    • Earliest
      J:8069 Mortensen RF, et al., Mouse serum amyloid P-component (SAP) levels controlled by a locus on chromosome 1. Immunogenetics. 1985;22(4):367-75
    • Latest
      J:340153 Wang L, et al., SAP deficiency aggravates periodontitis possibly via C5a-C5aR signaling-mediated defective macrophage phagocytosis of Porphyromonas gingivalis. J Adv Res. 2023 Aug;50:55-68
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/17/2024
    MGI 6.24     		The Jackson Laboratory