About   Help   FAQ
Ccl4 Gene Detail
Summary
  • Symbol
    Ccl4
  • Name
    C-C motif chemokine ligand 4
  • Synonyms
    Act-2, AT744.1, Mip1b, MIP-1B, MIP-1 beta, Scya4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98261
    NCBI Gene: 20303
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:83553410-83555509 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 51.09 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    131 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98261
 protein coding gene Chr11:83553410-83555509 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018857
 protein coding gene Chr11:85026588-85028696 (+)
A/J MGP_AJ_G0018824
 protein coding gene Chr11:81775110-81777218 (+)
AKR/J MGP_AKRJ_G0018794
 protein coding gene Chr11:84213385-84215490 (+)
BALB/cJ MGP_BALBcJ_G0018797
 protein coding gene Chr11:82192028-82194127 (+)
C3H/HeJ MGP_C3HHeJ_G0018611
 protein coding gene Chr11:84274833-84276941 (+)
C57BL/6NJ MGP_C57BL6NJ_G0019249
 protein coding gene Chr11:87613288-87615387 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016882
 protein coding gene Chr11:78890216-78892330 (+)
CAST/EiJ MGP_CASTEiJ_G0018166
 protein coding gene Chr11:84852680-84854767 (+)
CBA/J MGP_CBAJ_G0018582
 protein coding gene Chr11:91382790-91384898 (+)
DBA/2J MGP_DBA2J_G0018690
 protein coding gene Chr11:81373556-81375661 (+)
FVB/NJ MGP_FVBNJ_G0018679
 protein coding gene Chr11:80860158-80862257 (+)
LP/J MGP_LPJ_G0018760
 protein coding gene Chr11:85568196-85570304 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018706
 protein coding gene Chr11:91546731-91548830 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0019289
 protein coding gene Chr11:84493164-84495263 (+)
PWK/PhJ MGP_PWKPhJ_G0017935
 protein coding gene Chr11:82133009-82135117 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017727
 protein coding gene Chr11:84017327-84021155 (+)
WSB/EiJ MGP_WSBEiJ_G0018217
 protein coding gene Chr11:84345269-84347368 (+)



Homology
more
  • Human Ortholog
    CCL4, C-C motif chemokine ligand 4
  • Vertebrate Orthologs
    6
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CCL4, C-C motif chemokine ligand 4
  • Synonyms
    ACT2, AT744.1, G-26, HC21, LAG-1, LAG1, MIP1B, MIP1B1, MIP-1-beta, SCYA2, SCYA4
  • Links
    NCBI Gene ID: 6351
    neXtProt AC: NX_P13236
    UniProt: P13236

  • Chr Location
    17q12; chr17:36103827-36105621 (+)  GRCh38
  • Human Ortholog
    CCL4L1, C-C motif chemokine ligand 4 like 1
  • Synonyms
    AT744.2, CCL4L, LAG-1, LAG1, MIP-1-beta, SCYA4L, SCYA4L1, SCYA4L2
  • Links
    NCBI Gene ID: 388372
    neXtProt AC: NX_P13236, NX_Q8NHW4
    UniProt: Q8NHW4

  • Chr Location
    17q12; chr17:36210924-36212878 (+)  GRCh38
  • Human Ortholog
    CCL4L2, C-C motif chemokine ligand 4 like 2
  • Synonyms
    AT744.2, CCL4L, SCYA4L, SCYQ4L2
  • Links
    NCBI Gene ID: 9560
    neXtProt AC: NX_Q8NHW4

  • Chr Location
    17q12; chr17:36210924-36212878 (+)  GRCh38
Human Diseases
more
  • Diseases
    2 with human CCL4,CCL4L2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    17 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice with induced diabetic kidney disease show improved renal function, decreased renal glomerulosclerosis and fibrosis, decreased renal inflammation and reduced blood sugar levels compared to controls.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    9
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    771
  • Tissues
    42
  • cDNA Data
    13
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20303 NCBI Gene Model | MGI Sequence Detail 2100 C57BL/6J ±  kb
    transcript NM_013652 RefSeq | MGI Sequence Detail 674 ZRU/MplStud  
    polypeptide P14097 UniProt | EBI | MGI Sequence Detail 92 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      Genomic 4
      cDNA 14

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-12242, MGD-MRK-14335
    References
    more
    • Summaries
      All 95
      Developmental Gene Expression 8
      Gene Ontology 9
      Phenotypes 17
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:346348 Chang TT, et al., Macrophage inflammatory protein-1beta as a novel therapeutic target for renal protection in diabetic kidney disease. Biomed Pharmacother. 2023 Feb 28;161:114450
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory