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Srsf2 Gene Detail
Summary
  • Symbol
    Srsf2
  • Name
    serine and arginine-rich splicing factor 2
  • Synonyms
    D11Wsu175e, MRF-1, SC35, Sfrs10, Sfrs2
  • Feature Type
    protein coding gene
  • IDs
    MGI:98284
    NCBI Gene: 20382
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:116740727-116743920 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, 81.49 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    105 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98284
 protein coding gene Chr11:116740723-116744511 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019442
 protein coding gene Chr11:121012758-121015944 (-)
A/J MGP_AJ_G0019410
 protein coding gene Chr11:115675272-115678457 (-)
AKR/J MGP_AKRJ_G0019380
 protein coding gene Chr11:119213639-119216814 (-)
BALB/cJ MGP_BALBcJ_G0019385
 protein coding gene Chr11:116068509-116071685 (-)
C3H/HeJ MGP_C3HHeJ_G0019191
 protein coding gene Chr11:119478949-119482128 (-)
C57BL/6NJ MGP_C57BL6NJ_G0019834
 protein coding gene Chr11:124741022-124744250 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017457
 protein coding gene Chr11:112687870-112691041 (-)
CAST/EiJ MGP_CASTEiJ_G0018745
 protein coding gene Chr11:120898916-120902093 (-)
CBA/J MGP_CBAJ_G0019162
 protein coding gene Chr11:129599556-129602695 (-)
DBA/2J MGP_DBA2J_G0019274
 protein coding gene Chr11:115097466-115100652 (-)
FVB/NJ MGP_FVBNJ_G0019266
 protein coding gene Chr11:114657492-114660676 (-)
LP/J MGP_LPJ_G0019344
 protein coding gene Chr11:121359406-121362557 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019299
 protein coding gene Chr11:128655405-128658601 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0019873
 protein coding gene Chr11:119842935-119846118 (-)
PWK/PhJ MGP_PWKPhJ_G0018510
 protein coding gene Chr11:116433889-116437183 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018303
 protein coding gene Chr11:119575747-119578939 (-)
WSB/EiJ MGP_WSBEiJ_G0018797
 protein coding gene Chr11:119786257-119789437 (-)



Homology
more
  • Human Ortholog
    SRSF2, serine and arginine rich splicing factor 2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SRSF2, serine and arginine rich splicing factor 2
  • Synonyms
    PR264, SC-35, SC35, SFRS2, SFRS2A, SRp30b
  • Links
    NCBI Gene ID: 6427
    neXtProt AC: NX_Q01130
    UniProt: Q01130

  • Chr Location
    17q25.1; chr17:76734115-76737411 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Srsf2 mouse models; 4 with human SRSF2 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    30 phenotypes from 3 alleles in 5 genetic backgrounds
    29 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutants are embryonic lethal. Deaths occur prior to E7.5. Cre induced inactivation of this pre-mRNA splicing factor in the thymus impairs T-cell maturation. Inactivation in ventricular cardiomyocytes results in dilated cardiomyopathy without gross changes in cardiomyocyte development.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    30
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    893
  • Tissues
    64
  • cDNA Data
    30
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000034120 Ensembl Gene Model | MGI Sequence Detail 3194 C57BL/6J ±  kb
    transcript ENSMUST00000092404 Ensembl | MGI Sequence Detail 1899 Not Applicable  
    polypeptide ENSMUSP00000090059 Ensembl | MGI Sequence Detail 221 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      6 Sequences
    • Protein Ontology
      PR:000014757 splicing factor, arginine/serine-rich 2
      (term hierarchy)
    • InterPro Domains
      IPR012677 Nucleotide-binding alpha-beta plait domain superfamily
      IPR051106 RNA-binding and splicing regulatory protein
      IPR035979 RNA-binding domain superfamily
      IPR050441 RNA-binding motif
      IPR000504 RNA recognition motif domain
      IPR003954 RNA recognition motif domain, eukaryote
    • GlyGen
      Q62093 1 site, 1 N-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 39
      cDNA 32
      Primer pair 7

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-14372, MGD-MRK-28142, MGD-MRK-36448, MGI:104846, MGI:107871
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 16
      Diseases 1
      Gene Ontology 24
      Phenotypes 29
    • Earliest
      J:25670 Ayane M, et al., A differentially expressed murine RNA encoding a protein with similarities to two types of nucleic acid binding motifs. Nucleic Acids Res. 1991 Mar 25;19(6):1273-8
    • Latest
      J:358181 Wagner RE, et al., SRSF2 safeguards efficient transcription of DNA damage and repair genes. Cell Rep. 2024 Oct 23;43(11):114869
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory