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Sox15 Gene Detail
Summary
  • Symbol
    Sox15
  • Name
    SRY (sex determining region Y)-box 15
  • Feature Type
    protein coding gene
  • IDs
    MGI:98363
    NCBI Gene: 20670
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr11:69546140-69547553 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 11, Syntenic
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    119 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98363
 protein coding gene Chr11:69545863-69547553 (+)
129S1/SvImJ MGP_129S1SvImJ_G0018543
 protein coding gene Chr11:70112257-70113670 (+)
A/J MGP_AJ_G0018511
 protein coding gene Chr11:67471316-67472729 (+)
AKR/J MGP_AKRJ_G0018480
 protein coding gene Chr11:69480109-69481522 (+)
BALB/cJ MGP_BALBcJ_G0018483
 protein coding gene Chr11:67781051-67782464 (+)
C3H/HeJ MGP_C3HHeJ_G0018296
 protein coding gene Chr11:69500672-69502085 (+)
C57BL/6NJ MGP_C57BL6NJ_G0018934
 protein coding gene Chr11:72233167-72234580 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0016579
 protein coding gene Chr11:64390423-64391837 (+)
CAST/EiJ MGP_CASTEiJ_G0017851
 protein coding gene Chr11:69752092-69753505 (+)
CBA/J MGP_CBAJ_G0018269
 protein coding gene Chr11:75466320-75467733 (+)
DBA/2J MGP_DBA2J_G0018378
 protein coding gene Chr11:67053013-67054426 (+)
FVB/NJ MGP_FVBNJ_G0018368
 protein coding gene Chr11:66689212-66690625 (+)
LP/J MGP_LPJ_G0018448
 protein coding gene Chr11:70677890-70679303 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0018391
 protein coding gene Chr11:76062255-76063668 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0018976
 protein coding gene Chr11:69742869-69744282 (+)
PWK/PhJ MGP_PWKPhJ_G0017625
 protein coding gene Chr11:67702326-67703739 (+)
SPRET/EiJ MGP_SPRETEiJ_G0017415
 protein coding gene Chr11:69557126-69558539 (+)
WSB/EiJ MGP_WSBEiJ_G0017905
 protein coding gene Chr11:69414616-69416029 (+)



Homology
more
  • Human Ortholog
    SOX15, SRY-box transcription factor 15
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SOX15, SRY-box transcription factor 15
  • Synonyms
    SOX20, SOX26, SOX27
  • Links
    NCBI Gene ID: 6665
    neXtProt AC: NX_O60248
    UniProt: O60248

  • Chr Location
    17p13.1; chr17:7588178-7590094 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    4 phenotypes from 2 alleles in 2 genetic backgrounds
    15 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for disruptions in this gene display abnormalities in muscle fiber differentiation and in muscle regeneration after injury.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    876
  • Tissues
    103
  • cDNA Data
    11
  • Literature Summary
    16
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000041287 Ensembl Gene Model | MGI Sequence Detail 1414 C57BL/6J ±  kb
transcript ENSMUST00000047373 Ensembl | MGI Sequence Detail 861 Not Applicable  
polypeptide ENSMUSP00000048524 Ensembl | MGI Sequence Detail 231 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 21
    Genomic 2
    cDNA 11
    Primer pair 8

    Microarray probesets 2
Other
Accession IDs
less
MGD-MRK-14502, MGI:1890761
References
more
  • Summaries
    All 52
    Developmental Gene Expression 16
    Gene Ontology 8
    Phenotypes 15
  • Earliest
    J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
  • Latest
    J:273632 Planells B, et al., Differential isoform expression and alternative splicing in sex determination in mice. BMC Genomics. 2019 Mar 12;20(1):202
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory