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Surf4 Gene Detail
Summary
  • Symbol
    Surf4
  • Name
    surfeit gene 4
  • Synonyms
    Surf-4
  • Feature Type
    protein coding gene
  • IDs
    MGI:98445
    NCBI Gene: 20932
  • Member of
    Surf cluster
  • Alliance
    gene page
  • Transcription Start Sites
    3 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:26810052-26823801 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 19.10 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    311 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98445
 protein coding gene Chr2:26810052-26823940 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025502
 protein coding gene Chr2:24891683-24905643 (-)
A/J MGP_AJ_G0025479
 protein coding gene Chr2:23947572-23961459 (-)
AKR/J MGP_AKRJ_G0025449
 protein coding gene Chr2:24728122-24742010 (-)
BALB/cJ MGP_BALBcJ_G0025475
 protein coding gene Chr2:24065663-24079792 (-)
C3H/HeJ MGP_C3HHeJ_G0025236
 protein coding gene Chr2:24666887-24680756 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025919
 protein coding gene Chr2:25733726-25747403 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0023330
 protein coding gene Chr2:22786459-22800441 (-)
CAST/EiJ MGP_CASTEiJ_G0024699
 protein coding gene Chr2:24543997-24560901 (-)
CBA/J MGP_CBAJ_G0025214
 protein coding gene Chr2:26625396-26641831 (-)
DBA/2J MGP_DBA2J_G0025347
 protein coding gene Chr2:23764075-23778721 (-)
FVB/NJ MGP_FVBNJ_G0025309
 protein coding gene Chr2:23519291-23536876 (-)
LP/J MGP_LPJ_G0025433
 protein coding gene Chr2:24837328-24851005 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0025340
 protein coding gene Chr2:26684394-26700062 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025978
 protein coding gene Chr2:24669484-24684255 (-)
PWK/PhJ MGP_PWKPhJ_G0024447
 protein coding gene Chr2:23558157-23572092 (-)
SPRET/EiJ MGP_SPRETEiJ_G0024247
 protein coding gene Chr2:24821861-24835752 (-)
WSB/EiJ MGP_WSBEiJ_G0024768
 protein coding gene Chr2:24787205-24804659 (-)



Homology
more
  • Human Ortholog
    SURF4, surfeit 4
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SURF4, surfeit 4
  • Synonyms
    ERV29
  • Links
    NCBI Gene ID: 6836
    neXtProt AC: NX_O15260
    UniProt: O15260

  • Chr Location
    9q34.2; chr9:133361450-133377949 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    8 phenotypes from 3 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice die between E3.5 and E9.5. Mice homozygous for a conditional allele activated in the liver exhibit reduced circulating cholesterol and triglyceride levels.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    37
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    712
  • Tissues
    2
  • cDNA Data
    16
  • Literature Summary
    3
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20932 NCBI Gene Model | MGI Sequence Detail 13750 C57BL/6J ±  kb
    transcript NM_001421147 RefSeq | MGI Sequence Detail 2846 ZRU/MplStud  
    polypeptide Q64310 UniProt | EBI | MGI Sequence Detail 269 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 21
      Genomic 3
      cDNA 17
      Primer pair 1

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-14648, MGD-MRK-14653, MGI:2139142, MGI:2139145
    References
    more
    • Summaries
      All 51
      Developmental Gene Expression 3
      Gene Ontology 7
      Phenotypes 18
    • Earliest
      J:9681 Giallongo A, et al., Ribosomal protein L7a is encoded by a gene (Surf-3) within the tightly clustered mouse surfeit locus. Mol Cell Biol. 1989 Jan;9(1):224-31
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/22/2024
    MGI 6.24     		The Jackson Laboratory