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Tacr1 Gene Detail
Summary
  • Symbol
    Tacr1
  • Name
    tachykinin receptor 1
  • Synonyms
    neurokinin receptor 1, NK1-R, NK-1R, NK1 receptor, SPr, substance p receptor, Tac1r
  • Feature Type
    protein coding gene
  • IDs
    MGI:98475
    NCBI Gene: 21336
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:82379315-82537085 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 35.94 cM, cytoband D1
  • Mapping Data
    2 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5306 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98475
 protein coding gene Chr6:82378990-82537085 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030904
 protein coding gene Chr6:83345483-83512414 (+)
A/J MGP_AJ_G0030873
 protein coding gene Chr6:80176500-80338295 (+)
AKR/J MGP_AKRJ_G0030801
 protein coding gene Chr6:82465843-82627758 (+)
BALB/cJ MGP_BALBcJ_G0030883
 protein coding gene Chr6:80191618-80353213 (+)
C3H/HeJ MGP_C3HHeJ_G0030827
 protein coding gene Chr6:101739245-101908086 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031343
 protein coding gene Chr6:85617874-85782306 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0028529
 protein coding gene Chr6:78552587-78708657 (+)
CAST/EiJ MGP_CASTEiJ_G0029992
 protein coding gene Chr6:82458308-82635076 (+)
CBA/J MGP_CBAJ_G0030570
 protein coding gene Chr6:89027623-89196907 (+)
DBA/2J MGP_DBA2J_G0030723
 protein coding gene Chr6:79488283-79657418 (+)
FVB/NJ MGP_FVBNJ_G0030676
 protein coding gene Chr6:78708912-78870748 (+)
LP/J MGP_LPJ_G0030802
 protein coding gene Chr6:83346958-83512177 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030712
 protein coding gene Chr6:93343908-93514343 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0031367
 protein coding gene Chr6:82290562-82457533 (+)
PWK/PhJ MGP_PWKPhJ_G0029707
 protein coding gene Chr6:78365948-78530394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0029535
 protein coding gene Chr6:81148245-81307824 (+)
WSB/EiJ MGP_WSBEiJ_G0030073
 protein coding gene Chr6:82730948-82905558 (+)



Homology
more
  • Human Ortholog
    TACR1, tachykinin receptor 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TACR1, tachykinin receptor 1
  • Synonyms
    NK1R, NKIR, SPR, TAC1R
  • Links
    NCBI Gene ID: 6869
    neXtProt AC: NX_P25103
    UniProt: P25103

  • Chr Location
    2p12; chr2:75046463-75199520 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tacr1 mouse models; 2 with human TACR1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    35 phenotypes from 3 alleles in 7 genetic backgrounds
    119 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit reduced anxiety, pain and stress-related responses, reduced immunological response after a viral challenge, and reduced inflammatory responses.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    97
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    873
  • Tissues
    127
  • cDNA Data
    17
  • Literature Summary
    44
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000030043 Ensembl Gene Model | MGI Sequence Detail 157771 C57BL/6J ±  kb
    transcript ENSMUST00000203775 Ensembl | MGI Sequence Detail 4933 Not Applicable  
    polypeptide ENSMUSP00000145217 Ensembl | MGI Sequence Detail 407 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 23
      Genomic 3
      cDNA 17
      Primer pair 2
      Other 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-14702
    References
    more
    • Summaries
      All 207
      Developmental Gene Expression 44
      Diseases 1
      Gene Ontology 7
      Phenotypes 119
    • Earliest
      J:2342 Sundelin JB, et al., Molecular cloning of the murine substance K and substance P receptor genes. Eur J Biochem. 1992 Feb 1;203(3):625-31
    • Latest
      J:353123 Zhang D, et al., C-LTMRs mediate wet dog shakes via the spinoparabrachial pathway. bioRxiv. 2024 Jun 11;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory