About   Help   FAQ
Tcf3 Gene Detail
Summary
  • Symbol
    Tcf3
  • Name
    transcription factor 3
  • Synonyms
    A1, ALF2, bHLHb21, E12, E2A, E47, Pan1, Pan2, Tcfe2a
  • Feature Type
    protein coding gene
  • IDs
    MGI:98510
    NCBI Gene: 21423
  • Alliance
    gene page
  • Transcription Start Sites
    12 TSS
Location &
Maps
more
  • Sequence Map
    Chr10:80245348-80269481 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 39.72 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    472 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    16
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98510
 protein coding gene Chr10:80245348-80269814 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017503
 protein coding gene Chr10:81013552-81038369 (-)
A/J MGP_AJ_G0017481
 protein coding gene Chr10:78179222-78203345 (-)
AKR/J MGP_AKRJ_G0017442
 protein coding gene Chr10:80322942-80347069 (-)
BALB/cJ MGP_BALBcJ_G0017443
 protein coding gene Chr10:78409518-78433662 (-)
C3H/HeJ MGP_C3HHeJ_G0017266
 protein coding gene Chr10:80409571-80433698 (-)
C57BL/6NJ MGP_C57BL6NJ_G0017897
 protein coding gene Chr10:83816122-83840280 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015585
 protein coding gene Chr10:74398699-74423472 (-)
CAST/EiJ MGP_CASTEiJ_G0016833
 protein coding gene Chr10:80626979-80652393 (-)
CBA/J MGP_CBAJ_G0017238
 protein coding gene Chr10:87062142-87086349 (-)
DBA/2J MGP_DBA2J_G0017344
 protein coding gene Chr10:77395804-77419934 (-)
FVB/NJ MGP_FVBNJ_G0017338
 protein coding gene Chr10:76595583-76621616 (-)
LP/J MGP_LPJ_G0017415
 protein coding gene Chr10:81490044-81514190 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017364
 protein coding gene Chr10:89009295-89036541 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0017938
 protein coding gene Chr10:80309355-80333549 (-)
PWK/PhJ MGP_PWKPhJ_G0016614
 protein coding gene Chr10:77273689-77298458 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016403
 protein coding gene Chr10:79277274-79302467 (-)
WSB/EiJ MGP_WSBEiJ_G0016893
 protein coding gene Chr10:80343115-80368415 (-)



Homology
more
  • Human Ortholog
    TCF3, transcription factor 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TCF3, transcription factor 3
  • Synonyms
    AGM8, AGM8A, AGM8B, bHLHb21, E2A, E47, ITF1, p75, TCF-3, VDIR
  • Links
    NCBI Gene ID: 6929
    neXtProt AC: NX_P15923
    UniProt: P15923

  • Chr Location
    19p13.3; chr19:1609291-1652615 (-)  GRCh38
Human Diseases
more
  • Diseases
    3 with human TCF3 associations

Human Disease Mouse Models
      
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    2 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    54 phenotypes from 19 alleles in 24 genetic backgrounds
    52 phenotypes from multigenic genotypes
    104 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations are devoid of mature B cells, have a partial early block in T-lymphocyte development, and show high postnatal mortality. Many survivors develop T-cell lymphomas between 3 and 10 months of age.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    158
  • GO References
    58
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    886
  • Tissues
    136
  • cDNA Data
    148
  • Literature Summary
    39
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000020167 Ensembl Gene Model | MGI Sequence Detail 24134 C57BL/6J ±  kb
    transcript ENSMUST00000105342 Ensembl | MGI Sequence Detail 2928 Not Applicable  
    polypeptide ENSMUSP00000100979 Ensembl | MGI Sequence Detail 653 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 164
      Genomic 2
      cDNA 151
      Primer pair 7
      Other 4

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-14762, MGI:2143467, MGI:2143825
    References
    more
    • Summaries
      All 300
      Developmental Gene Expression 39
      Diseases 2
      Gene Ontology 58
      Phenotypes 104
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:345789 Parriott G, et al., Loss of thymocyte competition underlies the tumor suppressive functions of the E2a transcription factor in T-ALL. Leukemia. 2024 Mar;38(3):491-501
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory