Tef MGI Mouse Gene Detail - MGI:98663 - thyrotroph embryonic factor

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Tef Gene Detail

Symbol

Tef
Name

thyrotroph embryonic factor
Synonyms

2310028D20Rik

Feature Type

protein coding gene
IDs

MGI:98663
NCBI Gene: 21685
Alliance

gene page
Transcription Start Sites

10 TSS
Candidate for QTL

4 QTL

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Sequence Map

Chr15:81686874-81711064 bp, + strand
From NCBI annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 15, 38.25 cM
Mapping Data

16 experiments

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SNPs within 2kb

604 from dbSNP Build 142
Strain Annotations

18
RFLP

1

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates	Select Strains
C57BL/6J	MGI_C57BL6J_98663	protein coding gene	Chr15:81686622-81711064 (+)
129S1/SvImJ	MGP_129S1SvImJ_G0022120	protein coding gene	Chr15:82263624-82291477 (+)
A/J	MGP_AJ_G0022081	protein coding gene	Chr15:79365590-79390014 (+)
AKR/J	MGP_AKRJ_G0022056	protein coding gene	Chr15:81557418-81581786 (+)
BALB/cJ	MGP_BALBcJ_G0022087	protein coding gene	Chr15:79404615-79429183 (+)
C3H/HeJ	MGP_C3HHeJ_G0021858	protein coding gene	Chr15:81578426-81602814 (+)
C57BL/6NJ	MGP_C57BL6NJ_G0022530	protein coding gene	Chr15:85501338-85526100 (+)
CAROLI/EiJ	MGP_CAROLIEiJ_G0020059	protein coding gene	Chr15:75812962-75837995 (+)
CAST/EiJ	MGP_CASTEiJ_G0021378	protein coding gene	Chr15:82346590-82373410 (+)
CBA/J	MGP_CBAJ_G0021822	protein coding gene	Chr15:88154024-88180954 (+)
DBA/2J	MGP_DBA2J_G0021952	protein coding gene	Chr15:78836511-78862069 (+)
FVB/NJ	MGP_FVBNJ_G0021929	protein coding gene	Chr15:77877017-77902015 (+)
LP/J	MGP_LPJ_G0022020	protein coding gene	Chr15:82414339-82439553 (+)
NOD/ShiLtJ	MGP_NODShiLtJ_G0021950	protein coding gene	Chr15:93099201-93124382 (+)
NZO/HlLtJ	MGP_NZOHlLtJ_G0022544	protein coding gene	Chr15:81653447-81678831 (+)
PWK/PhJ	MGP_PWKPhJ_G0021120	protein coding gene	Chr15:78877370-78901544 (+)
SPRET/EiJ	MGP_SPRETEiJ_G0020957	protein coding gene	Chr15:81443015-81468455 (+)
WSB/EiJ	MGP_WSBEiJ_G0021430	protein coding gene	Chr15:82068335-82095698 (+)

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Human Ortholog

TEF, TEF transcription factor, PAR bZIP family member

Vertebrate Orthologs

4

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

TEF, TEF transcription factor, PAR bZIP family member
Links

HGNC:11722

NCBI Gene ID: 7008

neXtProt AC: NX_Q10587

UniProt: Q10587
Chr Location

22q13.2; chr22:41367333-41399326 (+) GRCh38

MGI Vertebrate Homology

Tef stringent orthology
1 human;1 mouse;1 rat;2 zebrafish
HCOP

vertebrate homology predictions: TEF
Gene Tree

Tef

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References

1 with disease annotations

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Phenotype Summary

2 phenotypes from 1 allele in 1 genetic background
16 phenotypes from multigenic genotypes
34 phenotype references

Phenotype Overview

Phenotype Overview

Blue squares indicate phenotypes directly attributed to mutations/alleles of this gene.

adipose tissue	behavior/neurological	cardiovascular system	cellular	craniofacial	digestive/alimentary system	embryo	endocrine/exocrine glands	growth/size/body	hearing/vestibular/ear	hematopoietic system	homeostasis/metabolism	integument	immune system	limbs/digits/tail	liver/biliary system	mortality/aging	muscle	nervous system	pigmentation	renal/urinary system	reproductive system	respiratory system	skeleton	taste/olfaction	neoplasm	vision/eye

Click cells to view annotations.

All Mutations and Alleles

9
Chemically induced (other)

1
Endonuclease-mediated

3
Gene trapped

1
Radiation induced

2
Targeted

2
Genomic Mutations

3 involving Tef
Incidental Mutations

APF
Find Mice (IMSR)

13 strains or lines available

Homozygous mutant are subject to seizures.

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All GO Annotations

20
GO References

7

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

746
Tissues

29
cDNA Data

150
Literature Summary

5

Tissue x Stage Matrix

Other Mouse Links

Allen Institute

GEO

Expression Atlas
Other Vertebrate Links

GEISHA TEF

Xenbase tef

ZFIN tefa, tefb

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All Sequences

114
RefSeq

22
UniProt

5
CCDS

CCDS27671.2, CCDS27672.1

Ensembl

ENSMUSG00000022389 (Evidence)
NCBI Gene

21685

Representative Sequences				Length	Strain/Species	Flank
	genomic	21685	NCBI Gene Model \| MGI Sequence Detail	24191	C57BL/6J	± kb
	transcript	NM_017376	RefSeq \| MGI Sequence Detail	4267	ZRU/MplStud
	polypeptide	Q9JLC6	UniProt \| EBI \| MGI Sequence Detail	301	Not Applicable

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UniProt

5 Sequences
Protein Ontology

PR:000016225 thyrotroph embryonic factor

(term hierarchy)
InterPro Domains

IPR004827 Basic-leucine zipper domain

IPR046347 Basic-leucine zipper domain superfamily

IPR040223 PAR basic leucine zipper protein

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All nucleic 154

cDNA 153

Primer pair 1

Microarray probesets 3

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MGD-MRK-14990, MGI:1914201

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Summaries

All 85

Developmental Gene Expression 5

Diseases 1

Gene Ontology 7

Phenotypes 34
Earliest

J:7688 Lane PW, et al., Association of megacolon with a new dominant spotting gene (Dom) in the mouse. J Hered. 1984 Nov-Dec;75(6):435-9
Latest

J:339462 Valakh V, et al., A transcriptional constraint mechanism limits the homeostatic response to activity deprivation in mammalian neocortex. Elife. 2023 Feb 7;12

TSS for Tef:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr132299	Chr15:81686771-81686778 (+)	-99 bp
Tssr132300	Chr15:81686887-81686896 (+)	18 bp
Tssr132301	Chr15:81686910-81686923 (+)	43 bp
Tssr132302	Chr15:81686936-81686959 (+)	74 bp
Tssr132303	Chr15:81686963-81686971 (+)	93 bp
Tssr132304	Chr15:81686974-81686986 (+)	106 bp
Tssr132305	Chr15:81686995-81687006 (+)	127 bp
Tssr132306	Chr15:81695649-81695692 (+)	8,797 bp
Tssr132307	Chr15:81695713-81695722 (+)	8,844 bp
Tssr132308	Chr15:81699304-81699333 (+)	12,445 bp

Tef is Candidate Gene for:

QTL	Genetic Location*	Genome Location (GRCm39)	Reference	QTL Note
Bw11	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Bwtq6	Chr15, syntenic		J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Dbsty4	Chr15, 41.96 cM	Chr15:87349271-87349416	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.
Mobq4	Chr15, 1.84 cM	Chr15:3489694-3489829	J:91835	The correlation between gene expression and dietary interaction was examined in a population of (BALB/cStCrlfC3H/Nctr x VY/WffC3Hf/Nctr-A(vy)/a)F1 animals. A/a and A/A animals were placed on a 70% (calorie restricted) or 100% (non-restricted) diet andliver mRNA levels were assessed for over 18,000 genes using DNA microarrays. Twenty-eight known genes showing statistically significant differential expression between the 70% and 100% calorie diets and A/a and A/A genotypes mapped near known diabesity QTLs. These genes may be considered further for candidate genes. On mouse Chromosome 15, Npr3 (6.7 cM) shows differential expression between restricted and unrestricted diets on the A/A background as well as between A/a and A/A animals on the restricted diet. Diabesity QTLs Bw11 (6 cM), Mob4 (6.7 cM), and Dob9 (12.3 cM) map near Npr3. Candidate genes for diabesity QTLs Dbsty4 (49.6 cM) and Bwtq6 (41.2 cM) are D15Wsu75e (46.7 cM), Gpt1 (40.3 cM), Tef (46.7 cM), and H1f0 (46.75 cM). Tef and H1f0both show differential expression between restricted and unrestricted diets on the A/A background. D15Wsu75e shows differential expression between A/a and A/A animals on both the restricted and unrestricted diets. Gpt1 shows differential expression between A/a and A/A animals on the restricted diet.

*cM position of peak correlated region/marker

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