About   Help   FAQ
Thbs3 Gene Detail
Summary
  • Symbol
    Thbs3
  • Name
    thrombospondin 3
  • Synonyms
    Thbs-3, TSP3
  • Feature Type
    protein coding gene
  • IDs
    MGI:98739
    NCBI Gene: 21827
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr3:89122487-89134144 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 3, 39.01 cM, cytoband E3-F1
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    273 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98739
 protein coding gene Chr3:89122470-89134148 (+)
129S1/SvImJ MGP_129S1SvImJ_G0027423
 protein coding gene Chr3:89415649-89428066 (+)
A/J MGP_AJ_G0027387
 protein coding gene Chr3:86455027-86472009 (+)
AKR/J MGP_AKRJ_G0027351
 protein coding gene Chr3:88550956-88562482 (+)
BALB/cJ MGP_BALBcJ_G0027396
 protein coding gene Chr3:86424096-86435689 (+)
C3H/HeJ MGP_C3HHeJ_G0027138
 protein coding gene Chr3:88749820-88763080 (+)
C57BL/6NJ MGP_C57BL6NJ_G0027842
 protein coding gene Chr3:92800218-92813045 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0025194
 protein coding gene Chr3:81940027-81951855 (+)
CAST/EiJ MGP_CASTEiJ_G0026584
 protein coding gene Chr3:89100605-89113576 (+)
CBA/J MGP_CBAJ_G0027112
 protein coding gene Chr3:95981768-95993301 (+)
DBA/2J MGP_DBA2J_G0027250
 protein coding gene Chr3:85838801-85850379 (+)
FVB/NJ MGP_FVBNJ_G0027218
 protein coding gene Chr3:84177853-84191302 (+)
LP/J MGP_LPJ_G0027359
 protein coding gene Chr3:90496568-90508964 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0027238
 protein coding gene Chr3:102201075-102213724 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0027901
 protein coding gene Chr3:88301053-88313838 (+)
PWK/PhJ MGP_PWKPhJ_G0026318
 protein coding gene Chr3:85711498-85722987 (+)
SPRET/EiJ MGP_SPRETEiJ_G0026137
 protein coding gene Chr3:87472035-87483506 (+)
WSB/EiJ MGP_WSBEiJ_G0026666
 protein coding gene Chr3:88692681-88705190 (+)



Homology
more
  • Human Ortholog
    THBS3, thrombospondin 3
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    THBS3, thrombospondin 3
  • Synonyms
    TSP3
  • Links
    NCBI Gene ID: 7059
    neXtProt AC: NX_P49746
    UniProt: P49746

  • Chr Location
    1q22; chr1:155195588-155209178 (-)  GRCh38
Human Diseases
less
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    3 phenotypes from 1 allele in 1 genetic background
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice at a young age are heavier and exhibit femurs with increased periosteal and endocortical diameters, greater moments of inertia and increased bending strength and failure loads, with these defects no longer detected in older mice. Femoral heads show accelerated bone ossification.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    8
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    869
  • Tissues
    101
  • cDNA Data
    47
  • Literature Summary
    11
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028047 Ensembl Gene Model | MGI Sequence Detail 11658 C57BL/6J ±  kb
    transcript ENSMUST00000029682 Ensembl | MGI Sequence Detail 3190 Not Applicable  
    polypeptide ENSMUSP00000029682 Ensembl | MGI Sequence Detail 956 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      4 Sequences
    • Protein Ontology
      PR:000000131 thrombospondin-3
      (term hierarchy)
    • InterPro Domains
      IPR013320 Concanavalin A-like lectin/glucanase domain superfamily
      IPR018097 EGF-like calcium-binding, conserved site
      IPR001881 EGF-like calcium-binding domain
      IPR000742 EGF-like domain
      IPR049883 NOTCH1 EGF-like calcium-binding domain
      IPR028507 Thrombospondin-3, coiled-coil domain
      IPR024665 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain
      IPR046970 Thrombospondin/cartilage oligomeric matrix protein, coiled-coil domain superfamily
      IPR008859 Thrombospondin, C-terminal
      IPR048287 Thrombospondin-like, N-terminal domain
      IPR003367 Thrombospondin, type 3-like repeat
      IPR017897 Thrombospondin, type 3 repeat
      IPR028974 TSP type-3 repeat
    • GlyGen
      Q05895 4 sites, 2 N-linked glycans (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 63
      Genomic 15
      cDNA 47
      Other 1

      Microarray probesets 2
    Other
    Accession IDs
    less
    MGD-MRK-15085, MGD-MRK-15088
    References
    more
    • Summaries
      All 56
      Developmental Gene Expression 11
      Diseases 1
      Gene Ontology 8
      Phenotypes 16
    • Earliest
      J:8863 Chou HS, et al., Germline organization of the murine T cell receptor beta-chain genes. Science. 1987 Oct 23;238(4826):545-8
    • Latest
      J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
    Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory