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Tpi1 Gene Detail
Summary
  • Symbol
    Tpi1
  • Name
    triosephosphate isomerase 1
  • Synonyms
    Tpi-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98797
    NCBI Gene: 21991
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr6:124787549-124791121 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 6, 59.17 cM
  • Mapping Data
    33 experiments
Strain
Comparison
more
  • SNPs within 2kb
    124 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    7
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98797
 protein coding gene Chr6:124787549-124791259 (-)
129S1/SvImJ MGP_129S1SvImJ_G0031269
 protein coding gene Chr6:128117372-128121059 (-)
A/J MGP_AJ_G0031239
 protein coding gene Chr6:123295894-123300681 (-)
AKR/J MGP_AKRJ_G0031167
 protein coding gene Chr6:126660367-126664216 (-)
BALB/cJ MGP_BALBcJ_G0031247
 protein coding gene Chr6:122896508-122900352 (-)
C3H/HeJ MGP_C3HHeJ_G0030970
 protein coding gene Chr6:126708335-126712875 (-)
C57BL/6NJ MGP_C57BL6NJ_G0031703
 protein coding gene Chr6:131501186-131504752 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0028853
 protein coding gene Chr6:120506884-120510591 (-)
CAST/EiJ MGP_CASTEiJ_G0030351
 protein coding gene Chr6:126910532-126916692 (-)
CBA/J MGP_CBAJ_G0030931
 protein coding gene Chr6:136531391-136536210 (-)
DBA/2J MGP_DBA2J_G0031087
 protein coding gene Chr6:122223595-122227161 (-)
FVB/NJ MGP_FVBNJ_G0031037
 protein coding gene Chr6:121125599-121129496 (-)
LP/J MGP_LPJ_G0031167
 protein coding gene Chr6:128288195-128291976 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031075
 protein coding gene Chr6:140591675-140595362 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0031738
 protein coding gene Chr6:126555630-126558633 (-)
PWK/PhJ MGP_PWKPhJ_G0030066
 protein coding gene Chr6:120451741-120457974 (-)
SPRET/EiJ MGP_SPRETEiJ_G0029895
 protein coding gene Chr6:124634054-124639281 (-)
WSB/EiJ MGP_WSBEiJ_G0030436
 protein coding gene Chr6:126913911-126917598 (-)



Homology
more
  • Human Ortholog
    TPI1, triosephosphate isomerase 1
  • Vertebrate Orthologs
    5
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    TPI1, triosephosphate isomerase 1
  • Synonyms
    HEL-S-49, TIM, TPI, TPID
  • Links
    NCBI Gene ID: 7167
    neXtProt AC: NX_P60174
    UniProt: P60174

  • Chr Location
    12p13.31; chr12:6867119-6870948 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Tpi1 mouse models; 2 with human TPI1 associations

Human Disease Mouse Models
      
IDs
 View 1 model
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    23 phenotypes from 8 alleles in 3 genetic backgrounds
    18 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mutants die at postimplantation stage. Heterozygotes are normal, but with 50% of normal enzyme activity. Mice heterozygous or homozygous for a hyperactivity allele are otherwise normal. Mice homozygous for a chemically induced allele exhibit symptoms of hemolytic anemia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    31
  • GO References
    24
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    911
  • Tissues
    159
  • cDNA Data
    24
  • Literature Summary
    19
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 21991 NCBI Gene Model | MGI Sequence Detail 3573 C57BL/6J ±  kb
    transcript NM_009415 RefSeq | MGI Sequence Detail 1469 Not Specified  
    polypeptide P17751 UniProt | EBI | MGI Sequence Detail 249 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 37
      Genomic 4
      cDNA 26
      Primer pair 5
      Other 2

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15179, MGD-MRK-15180, MGI:2141384
    References
    more
    • Summaries
      All 102
      Developmental Gene Expression 19
      Diseases 1
      Gene Ontology 24
      Phenotypes 18
    • Earliest
      J:5628 Bruns GA, et al., Human glyceraldehyde-3-phosphate dehydrogenase in man-rodent somatic cell hybrids. Science. 1976 Apr 2;192(4234):54-6
    • Latest
      J:346910 Ayyangar U, et al., Metabolic rewiring of macrophages by epidermal-derived lactate promotes sterile inflammation in the murine skin. EMBO J. 2024 Apr;43(7):1113-1134
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory