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Hsp90b1 Gene Detail
Summary
  • Symbol
    Hsp90b1
  • Name
    heat shock protein 90, beta (Grp94), member 1
  • Synonyms
    90 kDa, endoplasmin, ERp99, gp96, GRP94, Targ2, Tra-1, Tra1, tumor rejection antigen (gp96) 1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98817
    NCBI Gene: 22027
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
  • Candidate for QTL
    2 QTL
Location &
Maps
more
  • Sequence Map
    Chr10:86526705-86541308 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 10, 43.05 cM
  • Mapping Data
    20 experiments
Strain
Comparison
more
  • SNPs within 2kb
    298 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    3
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98817
 protein coding gene Chr10:86526073-86541373 (-)
129S1/SvImJ MGP_129S1SvImJ_G0017612
 protein coding gene Chr10:87668288-87685297 (-)
A/J MGP_AJ_G0017591
 protein coding gene Chr10:84771340-84787578 (-)
AKR/J MGP_AKRJ_G0017550
 protein coding gene Chr10:87150475-87167994 (-)
BALB/cJ MGP_BALBcJ_G0017554
 protein coding gene Chr10:85033710-85049439 (-)
C3H/HeJ MGP_C3HHeJ_G0017377
 protein coding gene Chr10:87156302-87171275 (-)
C57BL/6NJ MGP_C57BL6NJ_G0018011
 protein coding gene Chr10:90638209-90655281 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0015694
 protein coding gene Chr10:80566642-80581741 (-)
CAST/EiJ MGP_CASTEiJ_G0016943
 protein coding gene Chr10:87040547-87055679 (-)
CBA/J MGP_CBAJ_G0017346
 protein coding gene Chr10:94404447-94419738 (-)
DBA/2J MGP_DBA2J_G0017452
 protein coding gene Chr10:83874451-83889649 (-)
FVB/NJ MGP_FVBNJ_G0017445
 protein coding gene Chr10:83139638-83154489 (-)
LP/J MGP_LPJ_G0017526
 protein coding gene Chr10:88360827-88377353 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0017475
 protein coding gene Chr10:95975313-95991604 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0018048
 protein coding gene Chr10:87001174-87016940 (-)
PWK/PhJ MGP_PWKPhJ_G0016724
 protein coding gene Chr10:83880446-83895802 (-)
SPRET/EiJ MGP_SPRETEiJ_G0016512
 protein coding gene Chr10:85722867-85739771 (-)
WSB/EiJ MGP_WSBEiJ_G0017002
 protein coding gene Chr10:86956196-86973146 (-)



Homology
more
  • Human Ortholog
    HSP90B1, heat shock protein 90 beta family member 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HSP90B1, heat shock protein 90 beta family member 1
  • Synonyms
    ECGP, GP96, GRP94, HEL35, HEL-S-125m, TRA1
  • Links
    NCBI Gene ID: 7184
    neXtProt AC: NX_P14625
    UniProt: P14625

  • Chr Location
    12q23.3; chr12:103930107-103953931 (+)  GRCh38
  • Human Ortholog
    HSP90B2P, heat shock protein 90 beta family member 2, pseudogene
  • Synonyms
    GRP94b, GRP94P1, HSP, HSPCP2, TRA1P1, TRAP1
  • Links
    NCBI Gene ID: 7190
    UniProt: Q58FF3

  • Chr Location
    15q26.3; chr15:99257525-99260276 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with Hsp90b1 mouse models

Human Disease Mouse Models
      
IDs
 View 1 model
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    34 phenotypes from 4 alleles in 5 genetic backgrounds
    1 images
    47 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null mutation display embryonic lethality before somite formation with failure of primitive streak formation, absence of the chorion and amnion, and failure of mesoderm formation.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    45
  • GO References
    18
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    857
  • Tissues
    64
  • cDNA Data
    941
  • Literature Summary
    31
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 22027 NCBI Gene Model | MGI Sequence Detail 14604 C57BL/6J ±  kb
    transcript NM_011631 RefSeq | MGI Sequence Detail 2759 Not Specified  
    polypeptide P08113 UniProt | EBI | MGI Sequence Detail 802 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      9 Sequences
    • Protein Ontology
      PR:000008801 endoplasmin
      (term hierarchy)
    • InterPro Domains
      IPR019805 Heat shock protein Hsp90, conserved site
      IPR001404 Heat shock protein Hsp90 family
      IPR020575 Heat shock protein Hsp90, N-terminal
      IPR003594 Histidine kinase/HSP90-like ATPase
      IPR036890 Histidine kinase/HSP90-like ATPase superfamily
      IPR037196 HSP90, C-terminal domain
      IPR020568 Ribosomal protein uS5 domain 2-type superfamily
    • GlyGen
      P08113 8 sites, 19 N-linked glycans (6 sites), 1 O-linked glycan (2 sites)
    Molecular
    Reagents
    less
    • All nucleic 952
      Genomic 3
      cDNA 943
      Primer pair 3
      Other 3

      Microarray probesets 4
    Other
    Accession IDs
    less
    MGD-MRK-15216, MGD-MRK-15219, MGI:1100861
    References
    more
    • Summaries
      All 167
      Developmental Gene Expression 31
      Diseases 1
      Gene Ontology 18
      Phenotypes 47
    • Earliest
      J:137335 Roderick TH, Chromosomal inversions in studies of mammalian mutagenesis. Genetics. 1979 May;92(1 Pt 1 Suppl):s121-6
    • Latest
      J:353425 Xu Y, et al., Heat shock protein gp96 drives natural killer cell maturation and anti-tumor immunity by counteracting Trim28 to stabilize Eomes. Nat Commun. 2024 Feb 6;15(1):1106
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory