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Upk1a Gene Detail
Summary
  • Symbol
    Upk1a
  • Name
    uroplakin 1A
  • Synonyms
    1110031P12Rik, Tspan21, Upk1
  • Feature Type
    protein coding gene
  • IDs
    MGI:98911
    NCBI Gene: 109637
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr7:30302517-30312159 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 7, 18.78 cM
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    397 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_98911
 protein coding gene Chr7:30302517-30312272 (-)
129S1/SvImJ MGP_129S1SvImJ_G0032033
 protein coding gene Chr7:29611652-29621407 (-)
A/J MGP_AJ_G0032010
 protein coding gene Chr7:28808565-28817980 (-)
AKR/J MGP_AKRJ_G0031943
 protein coding gene Chr7:29541600-29551212 (-)
BALB/cJ MGP_BALBcJ_G0032017
 protein coding gene Chr7:28997372-29007643 (-)
C3H/HeJ MGP_C3HHeJ_G0031736
 protein coding gene Chr7:29998656-30014293 (-)
C57BL/6NJ MGP_C57BL6NJ_G0032483
 protein coding gene Chr7:30573096-30584756 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0029533
 protein coding gene Chr7:29839695-29848971 (-)
CAST/EiJ MGP_CASTEiJ_G0031070
 protein coding gene Chr7:23251361-23262459 (-)
CBA/J MGP_CBAJ_G0031702
 protein coding gene Chr7:32028073-32040775 (-)
DBA/2J MGP_DBA2J_G0031854
 protein coding gene Chr7:28536901-28546855 (-)
FVB/NJ MGP_FVBNJ_G0031811
 protein coding gene Chr7:28668490-28678113 (-)
LP/J MGP_LPJ_G0031935
 protein coding gene Chr7:29917915-29928378 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0031847
 protein coding gene Chr7:31265077-31274727 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0032511
 protein coding gene Chr7:29050533-29061044 (-)
PWK/PhJ MGP_PWKPhJ_G0030794
 protein coding gene Chr7:23574569-23585110 (-)
SPRET/EiJ MGP_SPRETEiJ_G0030629
 protein coding gene Chr7:20064936-20074605 (-)
WSB/EiJ MGP_WSBEiJ_G0031180
 protein coding gene Chr7:29441308-29450901 (-)



Homology
more
  • Human Ortholog
    UPK1A, uroplakin 1A
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    UPK1A, uroplakin 1A
  • Synonyms
    TSPAN21, UP1A, UPIA, UPKA
  • Links
    NCBI Gene ID: 11045
    neXtProt AC: NX_O00322
    UniProt: O00322

  • Chr Location
    19q13.12; chr19:35666517-35678481 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    6 phenotype references
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    13
  • GO References
    7
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    750
  • Tissues
    13
  • cDNA Data
    10
  • Literature Summary
    7
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 109637 NCBI Gene Model | MGI Sequence Detail 9643 C57BL/6J ±  kb
transcript NM_026815 RefSeq | MGI Sequence Detail 1308 ZRU/MplStud  
polypeptide Q9D132 UniProt | EBI | MGI Sequence Detail 257 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 14
    cDNA 11
    Primer pair 3

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-15365, MGD-MRK-15366, MGI:1915954, MGI:2142127, MGI:2142373
References
more
  • Summaries
    All 43
    Developmental Gene Expression 7
    Gene Ontology 7
    Phenotypes 6
  • Earliest
    J:15639 Ryan AM, et al., Chromosomal localization of uroplakin genes of cattle and mice. Mamm Genome. 1993 Nov;4(11):656-61
  • Latest
    J:345207 Munipalli SB, et al., Uroplakin 1a Knockout Mice Display Marginal Reduction in Fecundity, Decreased Bacterial Clearance Capacity, and Drastic Changes in the Testicular Transcriptome. Reprod Sci. 2023 Mar;30(3):914-927
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory