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Ybx1 Gene Detail
Summary
  • Symbol
    Ybx1
  • Name
    Y box protein 1
  • Synonyms
    dbpB, DNA binding protein B, EF1A, MSY1, Nsep1, YB-1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99146
    NCBI Gene: 22608
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:119135178-119151801 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 55.34 cM, cytoband D1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    407 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99146
 protein coding gene Chr4:119134524-119153462 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028695
 protein coding gene Chr4:120465575-120483438 (-)
A/J MGP_AJ_G0028655
 protein coding gene Chr4:115731260-115749302 (-)
AKR/J MGP_AKRJ_G0028608
 protein coding gene Chr4:118241569-118259135 (-)
BALB/cJ MGP_BALBcJ_G0028678
 protein coding gene Chr4:116349822-116366917 (-)
C3H/HeJ MGP_C3HHeJ_G0028393
 protein coding gene Chr4:119808191-119827992 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029119
 protein coding gene Chr4:125039943-125056501 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026396
 protein coding gene Chr4:109834148-109850703 (-)
CAST/EiJ MGP_CASTEiJ_G0027824
 protein coding gene Chr4:117131995-117152454 (-)
CBA/J MGP_CBAJ_G0028360
 protein coding gene Chr4:128419623-128436478 (-)
DBA/2J MGP_DBA2J_G0028507
 protein coding gene Chr4:116323954-116340771 (-)
FVB/NJ MGP_FVBNJ_G0028473
 protein coding gene Chr4:114838553-114858510 (-)
LP/J MGP_LPJ_G0028607
 protein coding gene Chr4:120583688-120599898 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028501
 protein coding gene Chr4:133286501-133303783 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029156
 protein coding gene Chr4:119320146-119336610 (-)
PWK/PhJ MGP_PWKPhJ_G0027547
 protein coding gene Chr4:113245751-113264063 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027373
 protein coding gene Chr4:115731518-115754801 (-)
WSB/EiJ MGP_WSBEiJ_G0027904
 protein coding gene Chr4:119323511-119339945 (-)



Homology
more
  • Human Ortholog
    YBX1, Y-box binding protein 1
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    YBX1, Y-box binding protein 1
  • Synonyms
    BP-8, CBF-A, CSDA2, CSDB, DBPB, EFI-A, MDR-NF1, NSEP-1, NSEP1, YB-1, YB1
  • Links
    NCBI Gene ID: 4904
    neXtProt AC: NX_P67809
    UniProt: P67809

  • Chr Location
    1p34.2; chr1:42682418-42703805 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    27 phenotypes from 3 alleles in 4 genetic backgrounds
    5 phenotypes from multigenic genotypes
    2 images
    23 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice exhibit embryonic and perinatal lethality and are severely growth retarded. Some mice exhibit craniofacial defects and respiratory failure. MEFs are more sensitive to oxidative stress resulting in premature senescence.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    92
  • GO References
    22
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    888
  • Tissues
    102
  • cDNA Data
    516
  • Literature Summary
    16
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028639 Ensembl Gene Model | MGI Sequence Detail 16624 C57BL/6J ±  kb
    transcript ENSMUST00000079644 Ensembl | MGI Sequence Detail 1628 Not Applicable  
    polypeptide ENSMUSP00000078589 Ensembl | MGI Sequence Detail 322 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 530
      cDNA 518
      Primer pair 8
      Other 4

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-15843, MGI:2140677
    References
    more
    • Summaries
      All 112
      Developmental Gene Expression 16
      Gene Ontology 22
      Phenotypes 23
    • Earliest
      J:1387 Shaughnessy M, et al., Absence of MHC gene expression in lens and cloning of dbpB/YB-1, a DNA-binding protein expressed in mouse lens. Curr Eye Res. 1992 Feb;11(2):175-81
    • Latest
      J:343217 Sanchez BJ, et al., The formation of HuR/YB1 complex is required for the stabilization of target mRNA to promote myogenesis. Nucleic Acids Res. 2023 Feb 22;51(3):1375-1392
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    10/29/2024
    MGI 6.24     		The Jackson Laboratory