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Zbtb25 Gene Detail
Summary
  • Symbol
    Zbtb25
  • Name
    zinc finger and BTB domain containing 25
  • Synonyms
    2810462M08Rik, 2900064P18Rik, Kup, Zfp-50, Zfp50
  • Feature Type
    protein coding gene
  • IDs
    MGI:99197
    NCBI Gene: 109929
  • Alliance
    gene page
  • Transcription Start Sites
    13 TSS
Location &
Maps
more
  • Sequence Map
    Chr12:76394556-76416376 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 12, 33.73 cM, cytoband D2
  • Mapping Data
    8 experiments
Strain
Comparison
more
  • SNPs within 2kb
    536 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99197
 protein coding gene Chr12:76387168-76416988 (-)
129S1/SvImJ MGP_129S1SvImJ_G0019856
 protein coding gene Chr12:76452892-76481368 (-)
A/J MGP_AJ_G0019814
 protein coding gene Chr12:73551617-73575298 (-)
AKR/J MGP_AKRJ_G0019789
 protein coding gene Chr12:75775085-75803538 (-)
BALB/cJ MGP_BALBcJ_G0019793
 protein coding gene Chr12:74023157-74049884 (-)
C3H/HeJ MGP_C3HHeJ_G0019599
 protein coding gene Chr12:76239073-76260768 (-)
C57BL/6NJ MGP_C57BL6NJ_G0020245
 protein coding gene Chr12:78797909-78823590 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0017863
 protein coding gene Chr12:70887079-70907538 (-)
CAST/EiJ MGP_CASTEiJ_G0019150
 protein coding gene Chr12:71048637-71072723 (-)
CBA/J MGP_CBAJ_G0019569
 protein coding gene Chr12:81849047-81872328 (-)
DBA/2J MGP_DBA2J_G0019685
 protein coding gene Chr12:73402128-73424377 (-)
FVB/NJ MGP_FVBNJ_G0019672
 protein coding gene Chr12:72246273-72267939 (-)
LP/J MGP_LPJ_G0019757
 protein coding gene Chr12:76431294-76456135 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0019711
 protein coding gene Chr12:84877007-84898690 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0020281
 protein coding gene Chr12:75253125-75276611 (-)
PWK/PhJ MGP_PWKPhJ_G0018916
 protein coding gene Chr12:67774069-67796349 (-)
SPRET/EiJ MGP_SPRETEiJ_G0018710
 protein coding gene Chr12:69768316-69795964 (-)
WSB/EiJ MGP_WSBEiJ_G0019202
 protein coding gene Chr12:75868508-75893239 (-)



Homology
more
  • Human Ortholog
    ZBTB25, zinc finger and BTB domain containing 25
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ZBTB25, zinc finger and BTB domain containing 25
  • Synonyms
    C14orf51, KUP, ZNF46
  • Links
    NCBI Gene ID: 7597
    neXtProt AC: NX_P24278
    UniProt: P24278

  • Chr Location
    14q23.3; chr14:64449106-64505213 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotype references
  • All Mutations and Alleles
    63
  • Chemically induced (other)
    1
  • Endonuclease-mediated
    2
  • Gene trapped
    59
  • Targeted
    1
  • Genomic Mutations
    1 involving Zbtb25
  • Find Mice (IMSR)
    49 strains or lines available
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    7
  • GO References
    2
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    730
  • Tissues
    15
  • cDNA Data
    22
  • Literature Summary
    2
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic ENSMUSG00000056459 Ensembl Gene Model | MGI Sequence Detail 21821 C57BL/6J ±  kb
transcript ENSMUST00000176102 Ensembl | MGI Sequence Detail 2707 Not Applicable  
polypeptide ENSMUSP00000135853 Ensembl | MGI Sequence Detail 439 Not Applicable  
For the selected sequence
Protein
Information
less
Molecular
Reagents
less
  • All nucleic 24
    cDNA 24

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-11665, MGD-MRK-15894, MGD-MRK-15949, MGI:1920038, MGI:1920240, MGI:2144893
References
more
  • Summaries
    All 40
    Developmental Gene Expression 2
    Gene Ontology 2
    Phenotypes 10
  • Earliest
    J:11157 Chardin P, et al., The KUP gene, located on human chromosome 14, encodes a protein with two distant zinc fingers. Nucleic Acids Res. 1991 Apr 11;19(7):1431-6
  • Latest
    J:308922 Medeiros de Araujo JA, et al., ZBTB20 is crucial for the specification of a subset of callosal projection neurons and astrocytes in the mammalian neocortex. Development. 2021 Aug 15;148(16):dev196642
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
11/12/2024
MGI 6.24 		The Jackson Laboratory