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Arf4 Gene Detail
Summary
  • Symbol
    Arf4
  • Name
    ARF GTPase 4
  • Feature Type
    protein coding gene
  • IDs
    MGI:99433
    NCBI Gene: 11843
  • Alliance
    gene page
  • Transcription Start Sites
    16 TSS
Location &
Maps
more
  • Sequence Map
    Chr14:26359289-26377997 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 14, 16.09 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    499 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99433
 protein coding gene Chr14:26359229-26386239 (+)
129S1/SvImJ MGP_129S1SvImJ_G0021083
 protein coding gene Chr14:19620341-19647196 (+)
A/J MGP_AJ_G0021032
 protein coding gene Chr14:18842706-18869177 (+)
AKR/J MGP_AKRJ_G0021009
 protein coding gene Chr14:19876507-19903317 (+)
BALB/cJ MGP_BALBcJ_G0021035
 protein coding gene Chr14:18957632-18986006 (+)
C3H/HeJ MGP_C3HHeJ_G0020819
 protein coding gene Chr14:19737642-19767703 (+)
C57BL/6NJ MGP_C57BL6NJ_G0021468
 protein coding gene Chr14:20440952-20468409 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0019031
 protein coding gene Chr14:19003104-19028893 (+)
CAST/EiJ MGP_CASTEiJ_G0020343
 protein coding gene Chr14:19344550-19373814 (+)
CBA/J MGP_CBAJ_G0020785
 protein coding gene Chr14:21251817-21284961 (+)
DBA/2J MGP_DBA2J_G0020908
 protein coding gene Chr14:18928160-18955245 (+)
FVB/NJ MGP_FVBNJ_G0020891
 protein coding gene Chr14:18891912-18918390 (+)
LP/J MGP_LPJ_G0020976
 protein coding gene Chr14:19885250-19913996 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020917
 protein coding gene Chr14:20587099-20614607 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0021501
 protein coding gene Chr14:19637427-19672844 (+)
PWK/PhJ MGP_PWKPhJ_G0020092
 protein coding gene Chr14:18301874-18329860 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019915
 protein coding gene Chr14:19115861-19144335 (+)
WSB/EiJ MGP_WSBEiJ_G0020399
 protein coding gene Chr14:19682738-19710878 (+)



Homology
more
  • Human Ortholog
    ARF4, ARF GTPase 4
  • Vertebrate Orthologs
    2
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    ARF4, ARF GTPase 4
  • Synonyms
    ARF2
  • Links
    NCBI Gene ID: 378
    neXtProt AC: NX_P18085
    UniProt: P18085

  • Chr Location
    3p14.3; chr3:57571363-57598220 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    17 phenotypes from 4 alleles in 4 genetic backgrounds
    7 phenotypes from multigenic genotypes
    1 images
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a gene trap allele exhibit embryonic lethality. Mice heterozygous for the gene trap allele exhibit failure to increase exploration of an object in a novel context, reduced spine density and reduced mESPC amplitudes.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    53
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    994
  • Tissues
    106
  • cDNA Data
    15
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 11843 NCBI Gene Model | MGI Sequence Detail 18709 C57BL/6J ±  kb
    transcript NM_007479 RefSeq | MGI Sequence Detail 1689 ZRU/MplStud  
    polypeptide P61750 UniProt | EBI | MGI Sequence Detail 180 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 18
      cDNA 16
      Primer pair 2

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16197, MGI:1353617
    References
    more
    • Summaries
      All 55
      Developmental Gene Expression 5
      Gene Ontology 13
      Phenotypes 16
    • Earliest
      J:18483 Schurmann A, et al., Cloning of two novel ADP-ribosylation factor-like proteins and characterization of their differential expression in 3T3-L1 cells. J Biol Chem. 1994 Jun 3;269(22):15683-8
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory