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Ckmt1 Gene Detail
Summary
  • Symbol
    Ckmt1
  • Name
    creatine kinase, mitochondrial 1, ubiquitous
  • Synonyms
    mi-CK, Mt-CK, UbCKmit
  • Feature Type
    protein coding gene
  • IDs
    MGI:99441
    NCBI Gene: 12716
  • Alliance
    gene page
  • Transcription Start Sites
    6 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:121188257-121194218 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 60.37 cM, cytoband F1-F3
  • Mapping Data
    7 experiments
Strain
Comparison
more
  • SNPs within 2kb
    128 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99441
 protein coding gene Chr2:121188195-121194218 (+)
129S1/SvImJ MGP_129S1SvImJ_G0026388
 protein coding gene Chr2:124247631-124253641 (+)
A/J MGP_AJ_G0026349
 protein coding gene Chr2:119170702-119176696 (+)
AKR/J MGP_AKRJ_G0026328
 protein coding gene Chr2:122516902-122522901 (+)
BALB/cJ MGP_BALBcJ_G0026362
 protein coding gene Chr2:119404587-119410604 (+)
C3H/HeJ MGP_C3HHeJ_G0026108
 protein coding gene Chr2:122994705-123000705 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026809
 protein coding gene Chr2:128320494-128326510 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0024189
 protein coding gene Chr2:114214920-114221214 (+)
CAST/EiJ MGP_CASTEiJ_G0025570
 protein coding gene Chr2:123320804-123326808 (+)
CBA/J MGP_CBAJ_G0026084
 protein coding gene Chr2:132785997-132792000 (+)
DBA/2J MGP_DBA2J_G0026223
 protein coding gene Chr2:118566808-118572805 (+)
FVB/NJ MGP_FVBNJ_G0026185
 protein coding gene Chr2:117386889-117392886 (+)
LP/J MGP_LPJ_G0026324
 protein coding gene Chr2:124504393-124510391 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0026204
 protein coding gene Chr2:137064916-137071034 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026864
 protein coding gene Chr2:122631960-122637965 (+)
PWK/PhJ MGP_PWKPhJ_G0025306
 protein coding gene Chr2:118178014-118184158 (+)
SPRET/EiJ MGP_SPRETEiJ_G0025105
 protein coding gene Chr2:121839302-121845304 (+)
WSB/EiJ MGP_WSBEiJ_G0025639
 protein coding gene Chr2:123456686-123462736 (+)



Homology
more
  • Human Ortholog
    CKMT1A, creatine kinase, mitochondrial 1A
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    CKMT1A, creatine kinase, mitochondrial 1A
  • Synonyms
    CKMT1, mia-CK, U-MtCK
  • Links
    NCBI Gene ID: 548596
    neXtProt AC: NX_P12532
    UniProt: P12532

  • Chr Location
    15q15.3
  • Human Ortholog
    CKMT1B, creatine kinase, mitochondrial 1B
  • Synonyms
    CKMT, CKMT1, UMTCK
  • Links
    NCBI Gene ID: 1159
    neXtProt AC: NX_P12532
    UniProt: P12532

  • Chr Location
    15q15.3
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    13 phenotypes from 1 allele in 1 genetic background
    9 phenotypes from multigenic genotypes
    16 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele have no visual or motor impairments but display diminished open field habituation and slower spatial learning acquisition in the Morris water maze task as well as a reduced acoustic startle response, higher threshold, and lack of prepulse inhibition.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    20
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1006
  • Tissues
    141
  • cDNA Data
    11
  • Literature Summary
    6
Sequences &
Gene Models
less
Representative SequencesLengthStrain/SpeciesFlank
genomic 12716 NCBI Gene Model | MGI Sequence Detail 5962 C57BL/6J ±  kb
transcript NM_001416952 RefSeq | MGI Sequence Detail 1607 ZRU/MplStud  
polypeptide P30275 UniProt | EBI | MGI Sequence Detail 418 Not Applicable  
For the selected sequence
Protein
Information
less
  • UniProt
    8 Sequences
  • Protein Ontology
    PR:000005516 creatine kinase U-type, mitochondrial
    (term hierarchy)
  • EC
    2.7.3.2
  • InterPro Domains
    IPR000749 ATP:guanido phosphotransferase
    IPR022415 ATP:guanido phosphotransferase active site
    IPR022414 ATP:guanido phosphotransferase, catalytic domain
    IPR022413 ATP:guanido phosphotransferase, N-terminal
    IPR036802 ATP:guanido phosphotransferase, N-terminal domain superfamily
    IPR014746 Glutamine synthetase/guanido kinase, catalytic domain
  • GlyGen
    P30275 1 site, 1 O-linked glycan (1 site)
Molecular
Reagents
less
  • All nucleic 19
    Genomic 3
    cDNA 12
    Primer pair 2
    Other 2

    Microarray probesets 5
Other
Accession IDs
less
MGD-MRK-16205
References
more
  • Summaries
    All 65
    Developmental Gene Expression 6
    Gene Ontology 13
    Phenotypes 16
  • Earliest
    J:109968 Roderick TH, et al., Nineteen paracentric chromosomal inversions in mice. Genetics. 1974 Jan;76(1):109-17
  • Latest
    J:326541 Cyagen Biosciences Inc., Cyagen Biosciences Website. 2022;
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory