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Ephb2 Gene Detail
Summary
  • Symbol
    Ephb2
  • Name
    Eph receptor B2
  • Synonyms
    Cek5, Drt, Erk, eteck, Hek5, Nuk, Prkm5, Qek5, Sek3, Tyro5
  • Feature Type
    protein coding gene
  • IDs
    MGI:99611
    NCBI Gene: 13844
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:136374850-136563299 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 69.00 cM, cytoband D-E
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    5303 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99611
 protein coding gene Chr4:136374850-136563637 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028972
 protein coding gene Chr4:139231649-139426440 (-)
A/J MGP_AJ_G0028931
 protein coding gene Chr4:133301651-133493607 (-)
AKR/J MGP_AKRJ_G0028883
 protein coding gene Chr4:137140564-137335903 (-)
BALB/cJ MGP_BALBcJ_G0028955
 protein coding gene Chr4:133957457-134151205 (-)
C3H/HeJ MGP_C3HHeJ_G0028669
 protein coding gene Chr4:137427292-137626384 (-)
C57BL/6NJ MGP_C57BL6NJ_G0029396
 protein coding gene Chr4:144201636-144396884 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0026667
 protein coding gene Chr4:126327478-126522034 (-)
CAST/EiJ MGP_CASTEiJ_G0028101
 protein coding gene Chr4:135589220-135784547 (-)
CBA/J MGP_CBAJ_G0028634
 protein coding gene Chr4:148153548-148378738 (-)
DBA/2J MGP_DBA2J_G0028783
 protein coding gene Chr4:133707954-133897007 (-)
FVB/NJ MGP_FVBNJ_G0028750
 protein coding gene Chr4:132655269-132850933 (-)
LP/J MGP_LPJ_G0028882
 protein coding gene Chr4:139310582-139513228 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028776
 protein coding gene Chr4:152330011-152532584 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0029434
 protein coding gene Chr4:137622993-137819556 (-)
PWK/PhJ MGP_PWKPhJ_G0027821
 protein coding gene Chr4:130493085-130689721 (-)
SPRET/EiJ MGP_SPRETEiJ_G0027647
 protein coding gene Chr4:133412659-133605949 (-)
WSB/EiJ MGP_WSBEiJ_G0028179
 protein coding gene Chr4:137777130-137976593 (-)



Homology
more
  • Human Ortholog
    EPHB2, EPH receptor B2
  • Vertebrate Orthologs
    4
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    EPHB2, EPH receptor B2
  • Synonyms
    BDPLT22, CAPB, DRT, EK5, EPHT3, ERK, Hek5, PCBC, Tyro5
  • Links
    NCBI Gene ID: 2048
    neXtProt AC: NX_P29323
    UniProt: P29323

  • Chr Location
    1p36.12; chr1:22710838-22921500 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human EPHB2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    20 phenotypes from 5 alleles in 5 genetic backgrounds
    30 phenotypes from multigenic genotypes
    94 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a null allele exhibit abnormal axon guidance, circling, head bobbing, and hyperactivity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    176
  • GO References
    34
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1353
  • Tissues
    388
  • cDNA Data
    82
  • Literature Summary
    124
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000028664 Ensembl Gene Model | MGI Sequence Detail 188450 C57BL/6J ±  kb
    transcript ENSMUST00000059287 Ensembl | MGI Sequence Detail 4804 Not Applicable  
    polypeptide ENSMUSP00000058135 Ensembl | MGI Sequence Detail 987 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 97
      Genomic 2
      cDNA 85
      Primer pair 3
      Other 7

      Microarray probesets 5
    Other
    Accession IDs
    less
    MGD-MRK-16396, MGD-MRK-35869, MGD-MRK-36579, MGD-MRK-39556, MGI:109557
    References
    more
    • Summaries
      All 298
      Developmental Gene Expression 124
      Gene Ontology 34
      Phenotypes 94
    • Earliest
      J:31545 Ben-David Y, et al., A mammalian protein kinase with potential for serine/threonine and tyrosine phosphorylation is related to cell cycle regulators. EMBO J. 1991 Feb;10(2):317-25
    • Latest
      J:346066 Rasool D, et al., PHF6-mediated transcriptional control of NSC via Ephrin receptors is impaired in the intellectual disability syndrome BFLS. EMBO Rep. 2024 Mar;25(3):1256-1281
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory