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Syt2 Gene Detail
Summary
  • Symbol
    Syt2
  • Name
    synaptotagmin II
  • Feature Type
    protein coding gene
  • IDs
    MGI:99666
    NCBI Gene: 20980
  • Alliance
    gene page
  • Transcription Start Sites
    10 TSS
Location &
Maps
more
  • Sequence Map
    Chr1:134574319-134680887 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 1, 58.24 cM
  • Mapping Data
    4 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3287 from dbSNP Build 142
  • Strain Annotations
    15
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99666
 protein coding gene Chr1:134574319-134690331 (+)
129S1/SvImJ MGP_129S1SvImJ_G0016512
 protein coding gene Chr1:138337068-138466112 (+)
A/J MGP_AJ_G0016495
 protein coding gene Chr1:133119800-133241305 (+)
AKR/J MGP_AKRJ_G0016460
 protein coding gene Chr1:137099043-137218668 (+)
BALB/cJ MGP_BALBcJ_G0016455
 protein coding gene Chr1:133446111-133563591 (+)
C3H/HeJ no annotation
C57BL/6NJ MGP_C57BL6NJ_G0016916
 protein coding gene Chr1:143370114-143492869 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0014627
 protein coding gene Chr1:126246620-126362618 (+)
CAST/EiJ MGP_CASTEiJ_G0015861
 protein coding gene Chr1:136249024-136370097 (+)
CBA/J MGP_CBAJ_G0016254
 protein coding gene Chr1:148312851-148438189 (+)
DBA/2J MGP_DBA2J_G0016360
 protein coding gene Chr1:132127270-132245613 (+)
FVB/NJ MGP_FVBNJ_G0016359
 protein coding gene Chr1:130763911-130883913 (+)
LP/J MGP_LPJ_G0016431
 protein coding gene Chr1:139599048-139722600 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0016384
 protein coding gene Chr1:154013234-154139758 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0016952
 protein coding gene Chr1:136833422-136952775 (+)
PWK/PhJ no annotation
SPRET/EiJ no annotation
WSB/EiJ MGP_WSBEiJ_G0015924
 protein coding gene Chr1:136855524-136979770 (+)



Homology
more
  • Human Ortholog
    SYT2, synaptotagmin 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    SYT2, synaptotagmin 2
  • Synonyms
    CMS7, CMS7A, CMS7B, MYSPC, SytII
  • Links
    NCBI Gene ID: 127833
    neXtProt AC: NX_Q8N9I0
    UniProt: Q8N9I0

  • Chr Location
    1q32.1; chr1:202590596-202710454 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with human SYT2 associations

Human Disease Mouse Models
      
IDs
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    19 phenotypes from 4 alleles in 4 genetic backgrounds
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for an ENU-induced allele are viable but sterile, weigh less and show ataxia and altered spontaneous and Ca2+-evoked neurotransmitter release. Mice homozygous for a null allele die at weaning showing growth arrest, motor dysfunction and impaired Ca2+-evoked neurotransmitter release.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    16
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    864
  • Tissues
    109
  • cDNA Data
    11
  • Literature Summary
    28
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 20980 NCBI Gene Model | MGI Sequence Detail 106569 C57BL/6J ±  kb
    transcript NM_009307 RefSeq | MGI Sequence Detail 7218 ZRU/MplStud  
    polypeptide P46097 UniProt | EBI | MGI Sequence Detail 422 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 15
      cDNA 13
      Primer pair 1
      Other 1

      Microarray probesets 6
    Other
    Accession IDs
    less
    MGD-MRK-16451, MGI:2138727
    References
    more
    • Summaries
      All 103
      Developmental Gene Expression 28
      Gene Ontology 16
      Phenotypes 28
    • Earliest
      J:134667 Roderick TH, et al., Two radiation-induced chromosomal inversions in mice (Mus musculus). Proc Natl Acad Sci U S A. 1970 Oct;67(2):961-7
    • Latest
      J:337770 Hu M, et al., Defective neurite elongation and branching in Nibp/Trappc9 deficient zebrafish and mice. Int J Biol Sci. 2023;19(10):3226-3248
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory