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Gpd2 Gene Detail
Summary
  • Symbol
    Gpd2
  • Name
    glycerol phosphate dehydrogenase 2, mitochondrial
  • Synonyms
    Gdm1
  • Feature Type
    protein coding gene
  • IDs
    MGI:99778
    NCBI Gene: 14571
  • Alliance
    gene page
  • Transcription Start Sites
    17 TSS
Location &
Maps
more
  • Sequence Map
    Chr2:57127690-57260731 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 2, 31.66 cM
  • Mapping Data
    9 experiments
Strain
Comparison
more
  • SNPs within 2kb
    3757 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99778
 protein coding gene Chr2:57127647-57260731 (+)
129S1/SvImJ MGP_129S1SvImJ_G0025744
 protein coding gene Chr2:56732184-56869640 (+)
A/J MGP_AJ_G0025720
 protein coding gene Chr2:54559965-54695088 (+)
AKR/J MGP_AKRJ_G0025690
 protein coding gene Chr2:56061414-56198862 (+)
BALB/cJ MGP_BALBcJ_G0025715
 protein coding gene Chr2:54669321-54802965 (+)
C3H/HeJ MGP_C3HHeJ_G0025476
 protein coding gene Chr2:56116224-56262354 (+)
C57BL/6NJ MGP_C57BL6NJ_G0026161
 protein coding gene Chr2:58485940-58627090 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0023567
 protein coding gene Chr2:52188103-52322241 (+)
CAST/EiJ MGP_CASTEiJ_G0024941
 protein coding gene Chr2:56151662-56292722 (+)
CBA/J MGP_CBAJ_G0025456
 protein coding gene Chr2:60598856-60751949 (+)
DBA/2J MGP_DBA2J_G0025587
 protein coding gene Chr2:54170926-54306631 (+)
FVB/NJ MGP_FVBNJ_G0025549
 protein coding gene Chr2:53723730-53856688 (+)
LP/J MGP_LPJ_G0025675
 protein coding gene Chr2:56606209-56747414 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0025580
 protein coding gene Chr2:62312542-62455339 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0026219
 protein coding gene Chr2:56039805-56180840 (+)
PWK/PhJ MGP_PWKPhJ_G0024682
 protein coding gene Chr2:53988826-54130099 (+)
SPRET/EiJ MGP_SPRETEiJ_G0024488
 protein coding gene Chr2:56166086-56307235 (+)
WSB/EiJ MGP_WSBEiJ_G0025008
 protein coding gene Chr2:56349659-56487729 (+)



Homology
more
  • Human Ortholog
    GPD2, glycerol-3-phosphate dehydrogenase 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GPD2, glycerol-3-phosphate dehydrogenase 2
  • Synonyms
    GDH2, GPDM, mGDH, mGPDH
  • Links
    NCBI Gene ID: 2820
    neXtProt AC: NX_P43304
    UniProt: P43304

  • Chr Location
    2q24.1; chr2:156400281-156613735 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human GPD2 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    1 with disease annotations
  • References
    1 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    25 phenotypes from 2 alleles in 4 genetic backgrounds
    17 phenotypes from multigenic genotypes
    28 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygotes for targeted null mutations exhibit diminished hepatic ATP levels, decreased adiposity and fasting blood glucose, and, on an inbred background, reductions in preweaning viability and fertility.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    19
  • GO References
    13
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    820
  • Tissues
    96
  • cDNA Data
    114
  • Literature Summary
    5
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14571 NCBI Gene Model | MGI Sequence Detail 133042 C57BL/6J ±  kb
    transcript NM_001145820 RefSeq | MGI Sequence Detail 5745 ZRU/MplStud  
    polypeptide Q64521 UniProt | EBI | MGI Sequence Detail 727 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    • UniProt
      2 Sequences
    • Protein Ontology
      PR:000008171 glycerol-3-phosphate dehydrogenase, mitochondrial
      (term hierarchy)
    • EC
      1.1.5.3
    • InterPro Domains
      IPR031656 Alpha-glycerophosphate oxidase, C-terminal
      IPR038299 Alpha-glycerophosphate oxidase, C-terminal domain superfamily
      IPR018247 EF-Hand 1, calcium-binding site
      IPR002048 EF-hand domain
      IPR011992 EF-hand domain pair
      IPR000447 FAD-dependent glycerol-3-phosphate dehydrogenase
      IPR006076 FAD dependent oxidoreductase
      IPR036188 FAD/NAD(P)-binding domain superfamily
    • GlyGen
      Q64521 2 sites, 1 N-linked glycan (1 site), 1 O-linked glycan (1 site)
    Molecular
    Reagents
    less
    • All nucleic 117
      cDNA 116
      Primer pair 1

      Microarray probesets 9
    Other
    Accession IDs
    less
    MGD-MRK-16564, MGI:2138752, MGI:2138952, MGI:2139193, MGI:2139355
    References
    more
    • Summaries
      All 72
      Developmental Gene Expression 5
      Diseases 1
      Gene Ontology 13
      Phenotypes 28
    • Earliest
      J:33877 Matsutani A, et al., Molecular cloning of human mitochondrial glycerophosphate dehydrogenase gene: genomic structure, chromosomal localization, and existence of a pseudogene. Biochem Biophys Res Commun. 1996 Jun 25;223(3):481-6
    • Latest
      J:346038 Clarke RA, et al., Immp2l Enhances the Structure and Function of Mitochondrial Gpd2 Dehydrogenase. Int J Mol Sci. 2024 Jan 12;25(2)
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    12/10/2024
    MGI 6.24     		The Jackson Laboratory