Mug2 MGI Mouse Gene Detail - MGI:99836

Mug2 Gene Detail

Symbol

Mug2
Name

murinoglobulin 2

Feature Type

protein coding gene
IDs

MGI:99836
NCBI Gene: 17837
Alliance

gene page
Transcription Start Sites

1 TSS

Sequence Map

Chr6:121983720-122062924 bp, + strand
From Ensembl annotation of GRCm39
View this region in JBrowse
Genome Browsers

Ensembl | UCSC | NCBI

Genetic Map

Chromosome 6, 57.52 cM
Mapping Data

1 experiment

SNPs within 2kb

1266 from dbSNP Build 142
Strain Annotations

5

For selected strains:

Strain	Gene Model ID	Feature Type	Coordinates
C57BL/6J	MGI_C57BL6J_99836	protein coding gene	Chr6:121983688-122062927 (+)
129S1/SvImJ	no annotation
A/J	no annotation
AKR/J	no annotation
BALB/cJ	no annotation
C3H/HeJ	MGP_C3HHeJ_G0030919	protein coding gene	Chr6:123312369-123696859 (+)
C57BL/6NJ	no annotation
CAROLI/EiJ	no annotation
CAST/EiJ	MGP_CASTEiJ_G0030308	protein coding gene	Chr6:124010396-124090748 (+)
CBA/J	no annotation
DBA/2J	no annotation
FVB/NJ	no annotation
LP/J	no annotation
NOD/ShiLtJ	no annotation
NZO/HlLtJ	MGP_NZOHlLtJ_G0031689	protein coding gene	Chr6:123547280-123626425 (+)
PWK/PhJ	MGP_PWKPhJ_G0030022	protein coding gene	Chr6:118213510-118216745 (+)
SPRET/EiJ	no annotation
WSB/EiJ	no annotation

Human Ortholog

PZP, PZP alpha-2-macroglobulin like

Vertebrate Orthologs

13

Vertebrate Orthology Source

Alliance of Genome Resources

Human Ortholog

PZP, PZP alpha-2-macroglobulin like
Synonyms

CPAMD6
Links

HGNC:9750

NCBI Gene ID: 5858

UniProt: P20742
Chr Location

12p13.31; chr12:9136472-9208395 (-) GRCh38

MGI Vertebrate Homology

Mug2 stringent orthology
1 human;1 mouse;2 rat;10 zebrafish
HCOP

vertebrate homology predictions: PZP
Gene Tree

Mug2

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Phenotype Summary

2 phenotype references

All Mutations and Alleles

2
Targeted

2
Incidental Mutations

Mutagenetix , APF , CvDC
Find Mice (IMSR)

78 strains or lines available

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All GO Annotations

4
GO References

3

Molecular Function

carbohydrate derivative binding	cytoskeletal protein binding	DNA binding	enzyme regulator	hydrolase	ligase	lipid binding	oxidoreductase	RNA binding	signaling receptor activity	signaling receptor binding	transcription	transferase	transporter

Biological Process

carbohydrate derivative metabolism	cell differentiation	cell population proliferation	cellular component organization	DNA-templated transcription	establishment of localization	homeostatic process	immune system process	lipid metabolic process	programmed cell death	protein metabolic process	response to stimulus	signaling	system development

Cellular Component

cell projection	cytoplasmic vesicle	cytoskeleton	cytosol	endoplasmic reticulum	endosome	extracellular region	Golgi apparatus	mitochondrion	membraneless organelle	nucleus	organelle envelope	organelle lumen	plasma membrane	protein-containing complex	synapse	vacuole

Click cells to view annotations.

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Expression Overview

GXD's primary emphasis is on endogenous gene expression during development. Click on grid cells to view annotations.

Blue cells = expressed in wild-type.
Gray triangles = other expression annotations only
(e.g. absence of expression or data from mutants).

early conceptus	embryo ectoderm	embryo endoderm	embryo mesoderm	embryo mesenchyme	extraembryonic component	alimentary system	auditory system	branchial arches	cardiovascular system	connective tissue	endocrine system	exocrine system	hemolymphoid system	integumental system	limbs	liver and biliary system	musculoskeletal system	nervous system	olfactory system	reproductive system	respiratory system	urinary system	visual system

Click cells to view annotations.

Assay Results

706
cDNA Data

23

Tissue x Stage Matrix

Other Mouse Links

GEO

Expression Atlas
Other Vertebrate Links

Xenbase cpamd8

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All Sequences

21
RefSeq

10
UniProt

1
CCDS

CCDS39619.1

Ensembl

ENSMUSG00000030131 (Evidence)
NCBI Gene

17837

			Length	Strain/Species	Flank
genomic	ENSMUSG00000030131	Ensembl Gene Model \| MGI Sequence Detail	79205	C57BL/6J	± kb
transcript	ENSMUST00000081777	Ensembl \| MGI Sequence Detail	4579	Not Applicable
polypeptide	ENSMUSP00000080469	Ensembl \| MGI Sequence Detail	1451	Not Applicable

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UniProt

1 Sequence
Protein Ontology

PR:000010928 murinoglobulin-2

(term hierarchy)
InterPro Domains

IPR001599 Alpha-2-macroglobulin

IPR011625 Alpha-2-macroglobulin, bait region domain

IPR050473 Alpha-2-macroglobulin/Complement system

IPR019742 Alpha-2-macroglobulin, conserved site

IPR041813 Alpha-2-macroglobulin, TED domain

IPR011626 Alpha-macroglobulin-like, TED domain

IPR047565 Alpha-macroglobulin-like, thiol-ester bond-forming region

IPR009048 Alpha-macroglobulin, receptor-binding

IPR036595 Alpha-macroglobulin, receptor-binding domain superfamily

IPR014756 Immunoglobulin E-set

IPR013783 Immunoglobulin-like fold

IPR002890 Macroglobulin domain

IPR041555 Macroglobulin domain MG3

IPR040839 Macroglobulin domain MG4

IPR008930 Terpenoid cyclases/protein prenyltransferase alpha-alpha toroid

IPR010916 TonB box, conserved site
GlyGen

P28666 8 sites, 1 N-linked glycan (1 site)

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All nucleic 25

Genomic 2

cDNA 23

Microarray probesets 3

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MGD-MRK-16626

Summaries

All 20

Gene Ontology 3

Phenotypes 2
Earliest

J:15557 Van Leuven F, et al., The alpha-macroglobulin family of proteinase inhibitors and the A/LRP receptor. Fifth International Workshop on Mouse Genome Mapping. 1991;:55
Latest

J:173534 Skarnes WC, et al., A conditional knockout resource for the genome-wide study of mouse gene function. Nature. 2011 Jun 16;474(7351):337-42

TSS for Mug2:

(View these features in JBrowse)

Transcription Start Site	Location	Distance from Gene 5'-end
Tssr58650	Chr6:122055663-122055666 (+)	71,945 bp

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources Funding Information Warranty Disclaimer, Privacy Notice, Licensing, & Copyright Send questions and comments to User Support.	last database update 11/12/2024 MGI 6.24