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Htr7 Gene Detail
Summary
  • Symbol
    Htr7
  • Name
    5-hydroxytryptamine (serotonin) receptor 7
  • Synonyms
    5-HT7
  • Feature Type
    protein coding gene
  • IDs
    MGI:99841
    NCBI Gene: 15566
  • Alliance
    gene page
Location &
Maps
more
  • Sequence Map
    Chr19:35936134-36034907 bp, - strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 19, 30.30 cM
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    2783 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99841
 protein coding gene Chr19:35935815-36035533 (-)
129S1/SvImJ MGP_129S1SvImJ_G0025068
 protein coding gene Chr19:34802212-34903611 (-)
A/J MGP_AJ_G0025044
 protein coding gene Chr19:33125345-33230066 (-)
AKR/J MGP_AKRJ_G0025012
 protein coding gene Chr19:34250018-34351865 (-)
BALB/cJ MGP_BALBcJ_G0025042
 protein coding gene Chr19:33220956-33326932 (-)
C3H/HeJ MGP_C3HHeJ_G0024801
 protein coding gene Chr19:34318904-34423318 (-)
C57BL/6NJ MGP_C57BL6NJ_G0025483
 protein coding gene Chr19:35816505-35919486 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0022901
 protein coding gene Chr19:32520977-32615366 (-)
CAST/EiJ MGP_CASTEiJ_G0024268
 protein coding gene Chr19:34097069-34199497 (-)
CBA/J MGP_CBAJ_G0024778
 protein coding gene Chr19:37502674-37620850 (-)
DBA/2J MGP_DBA2J_G0024910
 protein coding gene Chr19:33007811-33105144 (-)
FVB/NJ MGP_FVBNJ_G0024871
 protein coding gene Chr19:32818409-32913306 (-)
LP/J MGP_LPJ_G0024996
 protein coding gene Chr19:34901044-34998664 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0024902
 protein coding gene Chr19:37334332-37459103 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0025541
 protein coding gene Chr19:34330084-34431645 (-)
PWK/PhJ MGP_PWKPhJ_G0024020
 protein coding gene Chr19:32807225-32912962 (-)
SPRET/EiJ MGP_SPRETEiJ_G0023820
 protein coding gene Chr19:33177074-33276941 (-)
WSB/EiJ MGP_WSBEiJ_G0024335
 protein coding gene Chr19:34430143-34534475 (-)



Homology
more
  • Human Ortholog
    HTR7, 5-hydroxytryptamine receptor 7
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    HTR7, 5-hydroxytryptamine receptor 7
  • Synonyms
    5-HT7
  • Links
    NCBI Gene ID: 3363
    neXtProt AC: NX_P34969
    UniProt: P34969

  • Chr Location
    10q23.31; chr10:90740823-90858039 (-)  GRCh38
Human Diseases
more
  • Diseases
    1 with human HTR7 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    9 phenotypes from 5 alleles in 5 genetic backgrounds
    39 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice homozygous for a knock-out allele display lower electrically- and chemically-induced seizure thresholds. Mice homozygous for a different knock-out allele show enhanced coordination and higher thermal nociceptive thresholds. Other nullizygous mutantsfail to exhibit agonist-induced hypothermia.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    36
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    909
  • Tissues
    78
  • cDNA Data
    10
  • Literature Summary
    7
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000024798 Ensembl Gene Model | MGI Sequence Detail 98774 C57BL/6J ±  kb
    transcript ENSMUST00000099505 Ensembl | MGI Sequence Detail 1606 Not Applicable  
    polypeptide ENSMUSP00000097105 Ensembl | MGI Sequence Detail 470 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 17
      Genomic 1
      cDNA 11
      Primer pair 5

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16632
    References
    more
    • Summaries
      All 80
      Developmental Gene Expression 7
      Gene Ontology 6
      Phenotypes 39
    • Earliest
      J:20576 Lovenberg TW, et al., A novel adenylyl cyclase-activating serotonin receptor (5-HT7) implicated in the regulation of mammalian circadian rhythms. Neuron. 1993 Sep;11(3):449-58
    • Latest
      J:345621 Adams DJ, et al., Genetic determinants of micronucleus formation in vivo. Nature. 2024 Mar;627(8002):130-136
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory