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Gdi2 Gene Detail
Summary
  • Symbol
    Gdi2
  • Name
    GDP dissociation inhibitor 2
  • Synonyms
    Gdi3, GDI-B, GDIB, GDI beta
  • Feature Type
    protein coding gene
  • IDs
    MGI:99845
    NCBI Gene: 14569
  • Alliance
    gene page
  • Transcription Start Sites
    9 TSS
Location &
Maps
more
  • Sequence Map
    Chr13:3588075-3616261 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 13, 1.98 cM, cytoband A1
  • Mapping Data
    3 experiments
Strain
Comparison
more
  • SNPs within 2kb
    591 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99845
 protein coding gene Chr13:3588063-3617871 (+)
129S1/SvImJ MGP_129S1SvImJ_G0020193
 protein coding gene Chr13:6564-37100 (+)
A/J MGP_AJ_G0020149
 protein coding gene Chr13:129619-157617 (+)
AKR/J MGP_AKRJ_G0020124
 protein coding gene Chr13:111734-139272 (+)
BALB/cJ MGP_BALBcJ_G0020132
 protein coding gene Chr13:100278-129982 (+)
C3H/HeJ MGP_C3HHeJ_G0019936
 protein coding gene Chr13:174946-208956 (+)
C57BL/6NJ MGP_C57BL6NJ_G0020579
 protein coding gene Chr13:78422-108644 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0018191
 protein coding gene Chr13:78624-102369 (+)
CAST/EiJ MGP_CASTEiJ_G0019476
 protein coding gene Chr13:19929-49362 (+)
CBA/J MGP_CBAJ_G0019903
 protein coding gene Chr13:109869-138753 (+)
DBA/2J MGP_DBA2J_G0020020
 protein coding gene Chr13:24947-53528 (+)
FVB/NJ MGP_FVBNJ_G0020005
 protein coding gene Chr13:21108-47712 (+)
LP/J MGP_LPJ_G0020094
 protein coding gene Chr13:77072-114036 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0020041
 protein coding gene Chr13:111450-141552 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0020608
 protein coding gene Chr13:89290-122129 (+)
PWK/PhJ MGP_PWKPhJ_G0019238
 protein coding gene Chr13:86283-115374 (+)
SPRET/EiJ MGP_SPRETEiJ_G0019043
 protein coding gene Chr13:137981-168310 (+)
WSB/EiJ MGP_WSBEiJ_G0019534
 protein coding gene Chr13:14460-43621 (+)



Homology
more
  • Human Ortholog
    GDI2, GDP dissociation inhibitor 2
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    GDI2, GDP dissociation inhibitor 2
  • Synonyms
    HEL-S-46e, RABGDIB
  • Links
    NCBI Gene ID: 2665
    neXtProt AC: NX_P50395
    UniProt: P50395

  • Chr Location
    10p15.1; chr10:5765223-5842132 (-)  GRCh38
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    10 phenotypes from 2 alleles in 2 genetic backgrounds
    13 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Knock-out results in embryonic lethality between E10.5 to E14.5, with extensive cell death and cell loss is embryos and increased apoptosis in E12.5 livers.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    22
  • GO References
    11
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    833
  • Tissues
    120
  • cDNA Data
    32
  • Literature Summary
    6
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 14569 NCBI Gene Model | MGI Sequence Detail 28187 C57BL/6J ±  kb
    transcript NM_008112 RefSeq | MGI Sequence Detail 2681 C57BL/6  
    polypeptide Q61598 UniProt | EBI | MGI Sequence Detail 445 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 36
      cDNA 33
      Primer pair 1
      Other 2

      Microarray probesets 8
    Other
    Accession IDs
    less
    MGD-MRK-16636, MGD-MRK-33618, MGI:105939
    References
    more
    • Summaries
      All 57
      Developmental Gene Expression 6
      Gene Ontology 11
      Phenotypes 13
    • Earliest
      J:17786 Shisheva A, et al., Cloning, characterization, and expression of a novel GDP dissociation inhibitor isoform from skeletal muscle. Mol Cell Biol. 1994 May;14(5):3459-68
    • Latest
      J:348218 Wang M, et al., GDI2 deletion alleviates neurodegeneration and memory loss in the 5xFAD mice model of Alzheimer's disease. Biochim Biophys Acta Mol Basis Dis. 2024 Feb 19;1870(4):167093
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory