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Lama1 Gene Detail
Summary
  • Symbol
    Lama1
  • Name
    laminin, alpha 1
  • Synonyms
    Lama
  • Feature Type
    protein coding gene
  • IDs
    MGI:99892
    NCBI Gene: 16772
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr17:68004254-68129642 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 17, 38.80 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    4887 from dbSNP Build 142
  • Strain Annotations
    18
  • RFLP
    4
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99892
 protein coding gene Chr17:68004129-68129642 (+)
129S1/SvImJ MGP_129S1SvImJ_G0023992
 protein coding gene Chr17:69983662-70114963 (+)
A/J MGP_AJ_G0023950
 protein coding gene Chr17:67862344-67990040 (+)
AKR/J MGP_AKRJ_G0023919
 protein coding gene Chr17:68810989-68941439 (+)
BALB/cJ MGP_BALBcJ_G0023951
 protein coding gene Chr17:67816246-67943957 (+)
C3H/HeJ MGP_C3HHeJ_G0023715
 protein coding gene Chr17:69716953-69850872 (+)
C57BL/6NJ MGP_C57BL6NJ_G0024397
 protein coding gene Chr17:72603292-72733804 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0021843
 protein coding gene Chr17:63807775-63937111 (+)
CAST/EiJ MGP_CASTEiJ_G0023197
 protein coding gene Chr17:70079843-70218779 (+)
CBA/J MGP_CBAJ_G0023691
 protein coding gene Chr17:75521248-75658863 (+)
DBA/2J MGP_DBA2J_G0023819
 protein coding gene Chr17:66573994-66699913 (+)
FVB/NJ MGP_FVBNJ_G0023785
 protein coding gene Chr17:66074579-66200446 (+)
LP/J MGP_LPJ_G0023901
 protein coding gene Chr17:70706635-70840589 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0023813
 protein coding gene Chr17:75525040-75655275 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0024441
 protein coding gene Chr17:69263635-69395246 (+)
PWK/PhJ MGP_PWKPhJ_G0022943
 protein coding gene Chr17:65896495-66039394 (+)
SPRET/EiJ MGP_SPRETEiJ_G0022754
 protein coding gene Chr17:65999041-66130325 (+)
WSB/EiJ MGP_WSBEiJ_G0023263
 protein coding gene Chr17:70014396-70146316 (+)



Homology
more
  • Human Ortholog
    LAMA1, laminin subunit alpha 1
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    LAMA1, laminin subunit alpha 1
  • Synonyms
    LAMA, PTBHS, S-LAM-alpha
  • Links
    NCBI Gene ID: 284217
    neXtProt AC: NX_P25391
    UniProt: P25391

  • Chr Location
    18p11.31
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    51 phenotypes from 9 alleles in 7 genetic backgrounds
    1 phenotype from multigenic genotypes
    8 images
    31 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous null mice display embryonic lethality before somite formation with impaired formation of Reichert's membrane.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    52
  • GO References
    51
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    1361
  • Tissues
    351
  • cDNA Data
    23
  • Literature Summary
    183
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000032796 Ensembl Gene Model | MGI Sequence Detail 125389 C57BL/6J ±  kb
    transcript ENSMUST00000035471 Ensembl | MGI Sequence Detail 9526 Not Applicable  
    polypeptide ENSMUSP00000043957 Ensembl | MGI Sequence Detail 3083 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 43
      cDNA 23
      Primer pair 11
      Other 9

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-11733, MGD-MRK-16687, MGI:2146751
    References
    more
    • Summaries
      All 327
      Developmental Gene Expression 183
      Gene Ontology 51
      Phenotypes 31
    • Earliest
      J:14723 Oberbaumer I, New pUC-derived expression vectors for rapid construction of cDNA libraries. Gene. 1986;49(1):81-91
    • Latest
      J:352032 Wang L, et al., ADAMTS18-fibronectin interaction regulates the morphology of liver sinusoidal endothelial cells. iScience. 2024 Jul 19;27(7):110273
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/19/2024
    MGI 6.24     		The Jackson Laboratory