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Vcp Gene Detail
Summary
  • Symbol
    Vcp
  • Name
    valosin containing protein
  • Synonyms
    AAA ATPase p97, CDC48, p97, p97/VCP
  • Feature Type
    protein coding gene
  • IDs
    MGI:99919
    NCBI Gene: 269523
  • Alliance
    gene page
  • Transcription Start Sites
    1 TSS
Location &
Maps
more
  • Sequence Map
    Chr4:42979964-43000507 bp, - strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 4, 22.95 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    521 from dbSNP Build 142
  • Strain Annotations
    17
  • RFLP
    1
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99919
 protein coding gene Chr4:42979963-43000507 (-)
129S1/SvImJ MGP_129S1SvImJ_G0028196
 protein coding gene Chr4:41058210-41081691 (-)
A/J MGP_AJ_G0028152
 protein coding gene Chr4:39618610-39640368 (-)
AKR/J MGP_AKRJ_G0028104
 protein coding gene Chr4:40515065-40544976 (-)
BALB/cJ MGP_BALBcJ_G0028172
 protein coding gene Chr4:39707344-39730687 (-)
C3H/HeJ MGP_C3HHeJ_G0027894
 protein coding gene Chr4:41144970-41168057 (-)
C57BL/6NJ MGP_C57BL6NJ_G0028613
 protein coding gene Chr4:42583776-42612964 (-)
CAROLI/EiJ MGP_CAROLIEiJ_G0025925
 protein coding gene Chr4:37082745-37104022 (-)
CAST/EiJ MGP_CASTEiJ_G0027334
 protein coding gene Chr4:40621107-40641622 (-)
CBA/J no annotation
DBA/2J MGP_DBA2J_G0028009
 protein coding gene Chr4:39528375-39556249 (-)
FVB/NJ MGP_FVBNJ_G0027976
 protein coding gene Chr4:38756628-38777871 (-)
LP/J MGP_LPJ_G0028108
 protein coding gene Chr4:41125758-41147829 (-)
NOD/ShiLtJ MGP_NODShiLtJ_G0028000
 protein coding gene Chr4:47179330-47212146 (-)
NZO/HlLtJ MGP_NZOHlLtJ_G0028649
 protein coding gene Chr4:40713924-40737148 (-)
PWK/PhJ MGP_PWKPhJ_G0027060
 protein coding gene Chr4:39568604-39588037 (-)
SPRET/EiJ MGP_SPRETEiJ_G0026886
 protein coding gene Chr4:40270878-40292470 (-)
WSB/EiJ MGP_WSBEiJ_G0027414
 protein coding gene Chr4:40621612-40646184 (-)



Homology
more
  • Human Ortholog
    VCP, valosin containing protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    VCP, valosin containing protein
  • Synonyms
    CDC48, FTDALS6, p97, TERA
  • Links
    NCBI Gene ID: 7415
    neXtProt AC: NX_P55072
    UniProt: P55072

  • Chr Location
    9p13.3; chr9:35053928-35072668 (-)  GRCh38
Human Diseases
more
  • Diseases
    2 with Vcp mouse models; 6 with human VCP associations

Human Disease Mouse Models
      
IDs
 View 1 model
IDs
 View 2 models
      
IDs
IDs
IDs
IDs
IDs
IDs
Click on a disease name to see all genes associated with that disease.

  • Mutations/Alleles
    2 with disease annotations
  • References
    3 with disease annotations
Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    63 phenotypes from 6 alleles in 8 genetic backgrounds
    40 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Homozygous mutation of this gene results in lethality before weaning. Mice homozygous for a knock-in allele exhibit progressive muscle weakness, myopathy, decreased bone density, increased osteoclast genesis, and seizures. Heterozygosity for p.T262A mutation affects neural stem cells and leads to neurological defects. Heterozygosity for p.A232E mutation reduces sensitivity to diet-induced obesity.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    204
  • GO References
    45
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    778
  • Tissues
    30
  • cDNA Data
    24
  • Literature Summary
    8
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic 269523 NCBI Gene Model | MGI Sequence Detail 20544 C57BL/6J ±  kb
    transcript NM_009503 RefSeq | MGI Sequence Detail 3315 ZRU/MplStud  
    polypeptide Q01853 UniProt | EBI | MGI Sequence Detail 806 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 32
      Genomic 6
      cDNA 25
      Primer pair 1

      Microarray probesets 3
    Other
    Accession IDs
    less
    MGD-MRK-16720
    References
    more
    • Summaries
      All 152
      Developmental Gene Expression 8
      Diseases 3
      Gene Ontology 45
      Phenotypes 40
    • Earliest
      J:2369 Egerton M, et al., VCP, the mammalian homolog of cdc48, is tyrosine phosphorylated in response to T cell antigen receptor activation. EMBO J. 1992 Oct;11(10):3533-40
    • Latest
      J:357631 Huang TN, et al., Vcp overexpression and leucine supplementation extend lifespan and ameliorate neuromuscular junction phenotypes of a SOD1G93A-ALS mouse model. Hum Mol Genet. 2024 May 18;33(11):935-944
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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    Funding Information
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    Send questions and comments to User Support.     		last database update
    11/12/2024
    MGI 6.24     		The Jackson Laboratory