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Mafk Gene Detail
Summary
  • Symbol
    Mafk
  • Name
    v-maf musculoaponeurotic fibrosarcoma oncogene family, protein K (avian)
  • Synonyms
    NF-E2, Nfe2u, p18 NF-E2
  • Feature Type
    protein coding gene
  • IDs
    MGI:99951
    NCBI Gene: 17135
  • Alliance
    gene page
  • Transcription Start Sites
    5 TSS
Location &
Maps
more
  • Sequence Map
    Chr5:139777291-139788409 bp, + strand
    From NCBI annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 5, 78.81 cM
  • Mapping Data
    12 experiments
Strain
Comparison
more
  • SNPs within 2kb
    321 from dbSNP Build 142
  • Strain Annotations
    18
  • PCR
    1
  • RFLP
    2
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_99951
 protein coding gene Chr5:139777268-139788409 (+)
129S1/SvImJ MGP_129S1SvImJ_G0030290
 protein coding gene Chr5:144809489-144820602 (+)
A/J MGP_AJ_G0030259
 protein coding gene Chr5:138657653-138668801 (+)
AKR/J MGP_AKRJ_G0030191
 protein coding gene Chr5:142986481-142997615 (+)
BALB/cJ MGP_BALBcJ_G0030276
 protein coding gene Chr5:139901983-139914250 (+)
C3H/HeJ MGP_C3HHeJ_G0029987
 protein coding gene Chr5:143760091-143771200 (+)
C57BL/6NJ MGP_C57BL6NJ_G0030721
 protein coding gene Chr5:150155878-150167019 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0027939
 protein coding gene Chr5:132512892-132523986 (+)
CAST/EiJ MGP_CASTEiJ_G0029392
 protein coding gene Chr5:143174797-143186933 (+)
CBA/J MGP_CBAJ_G0029957
 protein coding gene Chr5:156350661-156361771 (+)
DBA/2J MGP_DBA2J_G0030107
 protein coding gene Chr5:138470084-138481235 (+)
FVB/NJ MGP_FVBNJ_G0030062
 protein coding gene Chr5:137598575-137609714 (+)
LP/J MGP_LPJ_G0030193
 protein coding gene Chr5:145421919-145434238 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0030093
 protein coding gene Chr5:158971498-158982690 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0030761
 protein coding gene Chr5:142820747-142831894 (+)
PWK/PhJ MGP_PWKPhJ_G0029107
 protein coding gene Chr5:137486296-137497312 (+)
SPRET/EiJ MGP_SPRETEiJ_G0028943
 protein coding gene Chr5:140493624-140504959 (+)
WSB/EiJ MGP_WSBEiJ_G0029466
 protein coding gene Chr5:143580167-143591305 (+)



Homology
more
  • Human Ortholog
    MAFK, MAF bZIP transcription factor K
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    MAFK, MAF bZIP transcription factor K
  • Synonyms
    NFE2U, P18
  • Links
    NCBI Gene ID: 7975
    neXtProt AC: NX_O60675
    UniProt: O60675

  • Chr Location
    7p22.3; chr7:1530702-1543043 (+)  GRCh38
Mutations,
Alleles, and
Phenotypes
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  • Phenotype Summary
    2 phenotypes from 1 allele in 1 genetic background
    16 phenotypes from multigenic genotypes
    20 phenotype references
Mice homozygous for a knock-out allele are viable, fertile, healthy and phenotypically normal with no detectable erythroid deficiencies.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    23
  • GO References
    10
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
membraneless organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
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Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    884
  • Tissues
    117
  • cDNA Data
    46
  • Literature Summary
    16
Sequences &
Gene Models
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Representative SequencesLengthStrain/SpeciesFlank
genomic 17135 NCBI Gene Model | MGI Sequence Detail 11119 C57BL/6J ±  kb
transcript NM_010757 RefSeq | MGI Sequence Detail 2825 ZRU/MplStud  
polypeptide Q61827 UniProt | EBI | MGI Sequence Detail 156 Not Applicable  
For the selected sequence
Protein
Information
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  • UniProt
    3 Sequences
  • Protein Ontology
    PR:000010051 transcription factor MafK
    (term hierarchy)
  • InterPro Domains
    IPR004827 Basic-leucine zipper domain
    IPR004826 Basic leucine zipper domain, Maf-type
    IPR046347 Basic-leucine zipper domain superfamily
    IPR024874 Transcription factor Maf family
    IPR008917 Transcription factor, Skn-1-like, DNA-binding domain superfamily
  • GlyGen
    Q61827 5 sites, 1 O-linked glycan (5 sites)
Molecular
Reagents
less
  • All nucleic 58
    Genomic 4
    cDNA 46
    Primer pair 7
    Other 1

    Microarray probesets 3
Other
Accession IDs
less
MGD-MRK-12104, MGD-MRK-16754, MGI:2141147
References
more
  • Summaries
    All 71
    Developmental Gene Expression 16
    Gene Ontology 10
    Phenotypes 20
  • Earliest
    J:20799 Andrews NC, et al., The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene. Proc Natl Acad Sci U S A. 1993 Dec 15;90(24):11488-92
  • Latest
    J:328989 Patel SD, et al., Deficiency of the bZIP transcription factors Mafg and Mafk causes misexpression of genes in distinct pathways and results in lens embryonic developmental defects. Front Cell Dev Biol. 2022;10:981893
Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory