A^vy
Spontaneous Allele Detail

Summary

• Symbol: A^vy
• Name: nonagouti; agouti viable yellow
• MGI ID: MGI:1855930
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: A^vy page

Spectrum of coat colors in A^vy/a mice

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: C3H/HeJ

Mutation description

• Allele Type: Spontaneous
• Mutation: Transposon insertion
• Mutation details: An intracisternal A particle (IAP) retrotransposon is inserted 100kb upstream of agouti coding sequences causing ectopic, allele-specific imprinting of agouti protein expression. (J:19977, J:21244, J:79708)
• Inheritance: Dominant

Disease models

Expression

In Mice Carrying this Mutation:	1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	1 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying A^vy

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 4 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

Notes

The A^vy allele arose spontaneously in the C3H/HeJ strain. A^vy resembles A^y except that homozygotes are viable and resemble heterozygotes with lower members of the series. Both homozygotes (A^vy/A^vy) and heterozygotes (A^vy/A and A^vy/a) show considerable variation in appearance, ranging from clear yellow, through mottling with dark patches, to a completely agouti-like coat (J:5475). The variation is strongly influenced by the agouti-locus genotype and strain genome of the dam (J:6103). A larger proportion of homozygotes than heterozygotes are clear yellow (J:13080). In combination with the dominant spotting allele Kit^W-2J, A^vy heterozygotes that have the agouti phenotype have much larger white spots than those of yellow or mottled yellow phenotype (J:12035). Homozygotes and heterozygotes tend to become obese, and the degree of obesity is correlated with the amount of yellow in the coat (J:13142), except that E^so prevents synthesis of yellow pigment in A^vy/- mice but does not prevent obesity (J:6103). A^vy resembles a in causing greater tumor susceptibility and lower graft vs. host reactivity (J:5320) and higher hepatic malic enzyme activity (J:5759). The greater tumor susceptibility as well as several altered immune responses occur in A^vy/a mice of mottled phenotype but not in those of agouti phenotype (J:7421).

Genbank ID for this mutation: S74479

References

• Original: J:13080 DICKIES MM, A new viable yellow mutation in the house mouse. J Hered. 1962 Mar-Apr;53:84-6
• All: 68 reference(s)