a
Spontaneous Allele Detail

Summary

• Symbol: a
• Name: nonagouti
• MGI ID: MGI:1855937
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: a page

Mutation origin

• Strain of Origin: old mutant of the mouse fancy

Mutation description

• Allele Type: Spontaneous
• Mutation: Viral insertion
• Mutation details: Characterization of this allele shows an insertion of DNA comprised of a 5.5kb virus-like element, VL30, into the first intron of the agouti gene. The VL30 element itself contains an additional 5.5 kb sequence, flanked by 526 bp of direct repeats (beta4 retroviral sequence). The host integration site is the same as for a^t-2Gso and A^w-38J and includes a duplication of four nucleotides of host DNA and a deletion of 2 bp from the end of each repeat. Northern analysis of mRNA from skin of homozygotes shows a smaller agouti message and levels 8 fold lower than found in wild-type. (J:16984, J:24934, J:278039)
• Inheritance: Recessive

Disease models

Expression

In Mice Carrying this Mutation:	50 assay results 4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	12 anatomical structure(s)

Tumor Data

List all tumor models in MMHCdb carrying a

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 229 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

Notes

Insertion of the LV30 retrotransposon without the beta4 retrovirus sequence does not cause the nonagouti phenotype. J:278039

References

• Original: J:12970 Markert CL, et al., The Effects of Genotype and Cell Environment on Melanoblast Differentiation in the House Mouse. Genetics. 1956 May;41(3):429-50
• All: 121 reference(s)