a^l
Radiation induced Allele Detail

Summary

• Symbol: a^l
• Name: nonagouti; nonagouti lethal
• MGI ID: MGI:1855940
• Synonyms: a^9H
• Gene: a Location: Chr2:154792519-154892932 bp, + strand Genetic Position: Chr2, 76.83 cM
• Alliance: a^l page

a^16H/a^l

Show the 1 phenotype image(s) involving this allele.

Mutation origin

• Strain of Origin: (C3H/HeH x 101/H)F1

Mutation description

• Allele Type: Radiation induced
• Mutation: Intergenic deletion
• Mutation details: This allele comprises a 75 kb deletion defined by a probe from the parotid secretory protein gene, Psp and located between 25 kb and 575 kb from the Psp coding sequences. The deletion does not extend as far as the closely linked Gdf5 locus. Homozygotes die prenatally and a^l/A^y mice also die prenatally, suggesting these alleles overlap at a site causing prenatal lethality. (J:9799)
• Inheritance: Recessive

Find Mice (IMSR)

• Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
• Carrying this Mutation: Mouse Strains: 0 strains available Cell Lines: 0 lines available
• Carrying any a Mutation: 463 strains or lines available

Notes

The a^l allele is recessive to A and a^e and dominant to a. a^l/a^e mice resemble a^e/a^e mice. As both a^l/a^l and a^l/A^y mice die prenatally, a^l and a may be deletions that overlap at a site that causes prenatal lethality. The a^l deletion does not extend as far as the closely linked Gdf5 locus (Lyon MF, 1985).

References

• Original: J:13694 Phillips RJS, New A-alleles. Mouse News Lett. 1976;55:14
• All: 7 reference(s)